Changes in the neurosecretory cells of the rat hypothalamus following ingestion of sodium chloride

Leveque, Theodore F.

doi:10.1002/ar.1091170406

Cited by 58 publications

(5 citation statements)

References 14 publications

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“…Experimentally induced osmoregulatory activity produces a variety of morphological changes in the SON neurons. The volumes of cells, nuclei, and nucleoli increase, the granules stainable with chrome alum hematoxylin phloxine and paraldehyde fuchsin are initially depleted, the Nissl substance is redistributed, and vacuolization of the cells and degenerative changes may occur after prolonged stress (Hillarp, 1949;Ortmann, 1950Ortmann, , 1951Laqueur, 1952;Leveque, 1953;Eichner, 1953;KovAcs et al, 1954;Bachrach, 1957;De Groot, 1957;Stutinsky, 1957;Eichner, 1958, 1960;Campanacci, 1960;Raiha, 1960;Sloper and King, 1963). An antagonism between the renal effects of adrenocortical and neurohypophyseal hormones has been suggested (Silvette and Britton, 1938; for references see Kennedy, 1960).…”

Section: Introductionmentioning

confidence: 99%

Respiration and Mitochondrial Content in Single Neurons of the Supraoptic Nucleus

Eneström

Hamberger

1968

The Journal of Cell Biology

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The study was undertaken to investigate the possible correlation of total volume of mitochondria per cell with the rate of succinate oxidation in isolated nerve cell bodies, after various functional stresses in the experimental animals. Significant cytological effects were found in the nerve cells of the supraoptic nucleus in rats which had been thirsting for 4-12 days or had been given 2% sodium chloride solution as a substitute for drinking water for a few weeks. Quantitation of mitochondria was done from electron micrographs. The cell volumes were calculated from sections of Epon-embedded tissue under phase-contrast microscopy. Succinate oxidation was measured on groups of 10 nerve cells with the microdiver technique. As a result of either thirst or sodium chloride load, the volume of mitochondria per nerve cell more than doubled. 'The rate of succinate oxidation was not changed after the rats had been thirsting but was enhanced by over 100% after they had drunk sodium chloride. A linear relationship was found for the amount of mitochondria versus respiration in the supraoptic neurons for all experimental groups except the thirsting animals. The mitochondria in the supraoptic neurons from thirsting animals were of the same size or smaller than those in controls, whereas in animals given sodium chloride solution the mitochondria were considerably enlarged. The observed effects were specific for the supraoptic nucleus.

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Section: Introductionmentioning

confidence: 99%

Respiration and Mitochondrial Content in Single Neurons of the Supraoptic Nucleus

Eneström

Hamberger

1968

The Journal of Cell Biology

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“…The above conclusions depend con siderably on Levcque's [24) observation that the N issl substance decreases dining hormone production and increases during the storage phase. Thus, ovariectom y also appears to have an effect in the produc tion of neurosecretion, b u t was less m arked than the effect produced by hypothyroidism .…”

Section: Resultsmentioning

confidence: 80%

The Effect of Thyroidectomy and Propylthiouracil Treatment on the Morphological Appearance of the Neurosecretory System of the Rat

Ford¹

1960

Cells Tissues Organs

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“…Histological techniques which afford indirect measures of overall cellular activity seem indicated. 2 Indirect measures which might be useful are cell size determinations (Edstrom, 1957;Geiger, 1960;Leveque, 1953), histochemical determinations (Adams, 1965), and autoradiographic measures (Altaian & Das, 1966;Belanger & Leblond, 1946;Pelc, 1947). Electrophysiological experiments on memory would at least have to be designed so that activity in many separate structures could be recorded simultaneously.…”

Section: Discussionmentioning

confidence: 99%

Parsimonious biological models of memory and reinforcement.

Pfaff¹

1969

Psychological Review

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The synaptic and ribonucleic acid theories of memory assume more than is necessary to show how neuronal changes could store information. Neurons acting as units could store information through modulations of the ordinary metabolic events which maintain electrical excitability. This type of memory model is parsimonious in that its assumptions are few, and widely accepted, and in that the postulated biochemical changes could occur in well described, commonplace metabolic reactions. This memory model does not depend on any particular reinforcement theory, but it is consistent with plausible electrophysiological and humoral mechanisms of reinforcement.

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Changes in the neurosecretory cells of the rat hypothalamus following ingestion of sodium chloride

Cited by 58 publications

References 14 publications

Respiration and Mitochondrial Content in Single Neurons of the Supraoptic Nucleus

Respiration and Mitochondrial Content in Single Neurons of the Supraoptic Nucleus

The Effect of Thyroidectomy and Propylthiouracil Treatment on the Morphological Appearance of the Neurosecretory System of the Rat

Parsimonious biological models of memory and reinforcement.

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