Changes in the oral microflora in patients with acute leukemia and related disorders during the period of induction therapy

Wahlin, Ylva Britt; Holm, Anna

doi:10.1016/0030-4220(88)90354-4

Cited by 78 publications

(38 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Lactobacilli levels also have been used, but they do not seem to be as effective as caries predictors as the S. mutans. [25][26][27][28] In this study, salivary Lactobacilli weren't statistically different in the study and reference groups that support the Wahlin and Holm [29] and Ou-Yang et al results. [12] The effects of chemotherapy on human salivary glands and the composition of human saliva are difficult to assess, and available information is relatively sparse and often contradictory.…”

Section: Discussionsupporting

confidence: 77%

Untitled

Bassir

2017

AJP

View full text Add to dashboard Cite

Purpose: This study was aimed to evaluate the caries activity in children with acute lymphoblastic leukemia (ALL) undergoing maintenance stage chemotherapy courses. Materials and Methods: This is an observationalanalytical and case-control study conducted on the 27 children (4-12 years old) with ALL who were in the maintenance phase of chemotherapy in the Ahvaz Shafa Hospital, Iran. The participants of the control group, matched in terms of age, gender, and cultural status with the case group, were selected among the healthy children referred to Ahvaz Razi Hospital, Iran. The children received only a clinical dental examination without radiographs. The number of decayed (D), missing (M) and filled (F), and teeth (T) were recorded based on the WHO based DMFT index and without the use of radiography. Then, after radiographic assessment, the stimulated saliva samples were collected from the subjects to assess the salivary Streptococcus mutans counts, salivary Lactobacilli counts, and salivary buffer capacity. Results: The salivary S. mutans counts in ALL children were significantly higher than the control group (P < 0.001). In both groups, Lactobacilli counts and salivary pH and DMFT were similar (P > 0.05). Furthermore, the ALL group tended to have lower salivary flow rate than healthy subjects (P < 0.05). Conclusions: Specific oral prevention regimes should be planned with more cautions for children suffered hematology illness undergoing antineoplastic therapy with respect to children without blood problems.

show abstract

Section: Discussionsupporting

confidence: 77%

Untitled

Bassir

2017

AJP

View full text Add to dashboard Cite

show abstract

“…Specimen Collection [9] We used 0.85 to 0.9% normal saline mouth gargles or oral washings for collecting specimens. Subjects were asked to gargle for 1 min and then the contents are collected in a sterile container.…”

Section: Exclusion Criteriamentioning

confidence: 99%

“…Such a shift is well established in patients with leukemia [9], but there are few published accounts highlighting such a shift in HIV-infected patients.…”

Section: Introductionmentioning

confidence: 99%

Oral Microflora: A Comparative Study in HIV and Normal Patients

Hegde

Kumar

Bhat

et al. 2011

Indian J Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

The study was designed to compare the oral microbiota in normal and HIV-infected individuals. The study tries to establish a significant shift in oral microflora in HIV-infected patients. Antibiotic sensitivity testing was performed to establish any rise in resistance against the antibiotics. It was a two and half year prospective study conducted in a tertiary care centre. The study group consisted of eighty subjects divided into two groups of control and HIV. The age range for this group was 9-75 years. The mean age in this group was 39.7 years. The male:female ratio was 2.75:1. Tuberculosis was the most common opportunistic infection in patients with HIV infection. The most common commensal micro organism isolated was the Viridans streptococci in 60% followed by Streptococcus pneumoniae in 23.33%. HIV Group: The most common commensal micro organism isolated was the Viridans streptococci in 42%; this was followed by the Micrococci spp. in 22% cases. S. pneumoniae was isolated in 6% of cases. The colony count for Viridans streptococci showed a heavy growth in 55.56% of cases in controls whereas the same in HIV group was 62.5%. Micrococcus spp. was isolated from 11 subjects in HIV group while it was not isolated from the controls. 50% subjects in the HIV group showed a heavy growth of Klebsiella spp. whereas controls showed only moderate and scanty growth. In patients with CD4? T cell count less than 50 cells/ll we found a heavy colonization of the oral cavity with Micrococcus spp., Acinetobacter and Klebsiella spp. Viridans streptococcus was not isolated in any of the patients with CD4? T cell count less than 50 cells/ll. As CD4? T cells counts improved to 51-100 cells/ll Viridans streptococcus colonies returned and 37.5% patients showed a heavy growth. Micrococcus spp. colonies were isolated till the CD4? T cells improved up to 300 cells/ll. At counts [ 300 cells/ll the oral microbiota became comparable to that of the controls. Many of the opportunistic infections in HIV are caused by commensal bacteria which are otherwise harmless in a normal individual. Our study is unique in that such a study of the oral commensals in HIV patients has never been reported. We found an increased colonization of the oral cavity by Micrococcus spp. which is a normal commensal of the skin.

show abstract

“…1987). These microorganisms have been associated with oral mucosal lesions in immunocompromised patients (Wahlin & Holm 1988), periodontitis (Rams et al. 1992) and root canal infections (Molander et al.…”

Section: Introductionmentioning

confidence: 99%