Changes in the serum concentrations of thyroxine-binding prealbumin and retinol-binding protein following burn injury

Moody, B J

doi:10.1016/0009-8981(82)90229-7

Cited by 43 publications

(9 citation statements)

References 7 publications

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“…This finding is in agreement with previous studies in non-pregnant subjects in which acute stressful conditions such as a critical illness of pulmonary origin, [36] sepsis, [36] elective surgery, [36] or burn injury [61] were all associated with lower circulating concentrations of RBP4 than in healthy controls. Furthermore, RBP was the only acute phase reactant protein able to discriminate in patients with gastric carcinoma between those infected by Helicobacter pillory and those who were not (significantly lower concentration in the infected group) [82].…”

Section: Discussionsupporting

confidence: 92%

Maternal plasma retinol binding protein 4 in acute pyelonephritis during pregnancy

Vaisbuch¹,

Romero²,

Mazaki‐Tovi³

et al. 2010

Journal of Perinatal Medicine

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Objective: Adipokines have been implicated in metabolic regulation and the immune response thus providing a molecular mechanism for the interaction between these two systems. Retinol binding protein 4 (RBP4) is a novel adipokine that plays a role in the pathophysiology of obesity-induced insulin resistance, as well as in the modulation of inflammation. The aim of this study was to determine whether there are changes in maternal plasma concentrations of RBP4 in pregnant women with acute pyelonephritis. Study design: This cross-sectional study included pregnant women in the following groups: 1) normal pregnancy (ns80); 2) pyelonephritis (ns39). Maternal plasma RBP4 concentrations were determined by enzyme-linked immunoassays. Non-parametric statistics were used for analyses. Results: 1) The median maternal plasma RBP4 concentration was lower in patients with acute pyelonephritis than in those with a normal pregnancy (3709.6 ng/mL, interquartile range (IQR) 2917.7-5484.2 vs. 9167.6 ng/mL, IQR 7496.1-10,384.1, P-0.001; 2) the median maternal plasma RBP4 concentration did not differ significantly between patients with acute pyelonephritis who had a positive blood culture and those with a negative culture (3285.3 ng/mL, IQR 2274.1-4741.1 vs. 3922.6 ng/mL, IQR 3126.8-5547.1, respectively, Ps0.2); and 3) lower maternal plasma RBP4 concentrations were independently associated with pyelonephritis after adjustment for confounding factors. Conclusions:In contrast to what has been reported in preeclampsia, acute pyelonephritis during pregnancy is associated with lower maternal plasma RBP4 concentrations than in normal pregnancy. This finding suggests that the acute maternal inflammatory process associated with pyelonephritis is fundamentally different from that of the chronic systemic inflammatory process suggested in preeclampsia, in which RBP4 concentrations were found to be elevated.

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Section: Discussionsupporting

confidence: 92%

Maternal plasma retinol binding protein 4 in acute pyelonephritis during pregnancy

Vaisbuch¹,

Romero²,

Mazaki‐Tovi³

et al. 2010

Journal of Perinatal Medicine

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“…These observations would suggest an acute stress response. Low levels of circulating RBP4 and leptin were previously observed after burn injury or trauma or both [9,10], and low levels of adiponectin were reported in rats with sepsis [11]. It is unclear what mediates this acute lowering with stress.…”

Section: Discussionmentioning

confidence: 99%

Adiponectin, retinol-binding protein 4, and leptin in protracted critical illness of pulmonary origin

et al. 2009

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IntroductionCritically ill patients requiring intensive care uniformly develop insulin resistance. This is most pronounced in patients with sepsis. Recently, several hormones secreted by adipose tissue have been identified to be involved in overall insulin sensitivity in metabolic syndrome-related conditions. However, little is known about these adipokines in critical illness.MethodsWe studied circulating levels of the adipokines adiponectin, retinol-binding protein 4 (RBP4), and leptin during critical illness, and the impact of intensive insulin therapy, a therapy shown to affect insulin sensitivity, in serum samples from prolonged critically ill patients with a respiratory critical illness (n = 318). For comparison, we studied healthy subjects (n = 22) and acutely stressed patients (n = 22).ResultsDuring acute critical illness, circulating levels of adiponectin, RBP4, and leptin were low. Patients with sepsis had lower levels of leptin and RBP4 than did nonseptic patients. When critical illness was sustained, adipokine levels returned to normal reference values. Insulin therapy enhanced adiponectin, blunted the rise of RBP4, and did not alter leptin levels.ConclusionsAcute critical illness is associated with immediate, but transiently low serum adipokine levels. Adiponectin and RBP4 are associated with altered insulin resistance in critical illness.

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“…Diets deficient in fresh vegetables and meats account for low levels of vitamin A intake, which can result in frank deficiency in the setting of burns, fractures, and surgical interventions. All of these injuries lead to decreases in plasma vitamin A levels, RBP, and increased urinary excretion of vitamin A . In addition, hyperactive adrenal cortisol activity, as seen during heightened stress, or administration of high doses of cortisone results in decreased liver, plasma, and adrenal levels of vitamin A .…”

Section: Vitamin a And Wound Healingmentioning

confidence: 99%

“…All of these injuries lead to decreases in plasma vitamin A levels, RBP, and increased urinary excretion of vitamin A. 56,57 In addition, hyperactive adrenal cortisol activity, as seen during heightened stress, or administration of high doses of cortisone results in decreased liver, plasma, and adrenal levels of vitamin A. 58 For this reason, systemic inflammatory states in general are associated with low levels of vitamin A.…”

Section: Vitamin a And Wound Healingmentioning

confidence: 99%

The Role of Vitamin A in Wound Healing

2019

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Vitamin A is an essential micronutrient that comes in multiple forms, including retinols, retinals, and retinoic acids. Dietary vitamin A is absorbed as retinol from preformed retinoids or as pro–vitamin A carotenoids that are converted into retinol in the enterocyte. These are then delivered to the liver for storage via chylomicrons and later released into the circulation and to its biologically active tissues bound to retinol‐binding protein. Vitamin A is a crucial component of many important and diverse biological functions, including reproduction, embryological development, cellular differentiation, growth, immunity, and vision. Vitamin A functions mostly through nuclear retinoic acid receptors, retinoid X receptors, and peroxisome proliferator‐activated receptors. Retinoids regulate the growth and differentiation of many cell types within skin, and its deficiency leads to abnormal epithelial keratinization. In wounded tissue, vitamin A stimulates epidermal turnover, increases the rate of re‐epithelialization, and restores epithelial structure. Retinoids have the unique ability to reverse the inhibitory effects of anti‐inflammatory steroids on wound healing. In addition to its role in the inflammatory phase of wound healing, retinoic acid has been demonstrated to enhance production of extracellular matrix components such as collagen type I and fibronectin, increase proliferation of keratinocytes and fibroblasts, and decrease levels of degrading matrix metalloproteinases.

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Changes in the serum concentrations of thyroxine-binding prealbumin and retinol-binding protein following burn injury

Cited by 43 publications

References 7 publications

Maternal plasma retinol binding protein 4 in acute pyelonephritis during pregnancy

Maternal plasma retinol binding protein 4 in acute pyelonephritis during pregnancy

Adiponectin, retinol-binding protein 4, and leptin in protracted critical illness of pulmonary origin

The Role of Vitamin A in Wound Healing

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