Changes in the Structure of the Benzylpenicillin Sodium Salt Molecule under the Pulsed Magnetic Field

Abstract

The study aims at the Fourier spectra of an antibiotic exposed to a high-intensity pulsed magnetic field. The applied frequency was f = 40 kHz, with a number of pulses n = 1, at intensities of the pulsed magnetic field H = 0.09 × 106 А/m, Н = 0.50 × 106 А/m, Н = 0.82 × 106 А/m. It was assumed that under the conditions of the pulsed magnetic field there might be a change in the structure of the drug molecule. The research has revealed that an increase in the pulsed magnetic field power leads first to a decrease in the intensity of the band in the Fourier spectrum, and then to its increase. In addition, changes were recorded in the amide group of benzylpenicillin sodium salt molecules depending on the intensity of the pulsed magnetic field applied to the antibiotic.

Antibiotic-Powered Energy Harvesting: Introducing Benzylpenicillin as an Efficient Tribopositive Material for Triboelectric Nanogenerators

“…The amine (cyclic amide in lactam ring) along with the carbonyl group (-C=O) present in penicillin's structure, induce a specific charge distribution over the molecule [52]. This results in an interfacial dipole with a magnitude of 4.7 Debye [49]. Thio (S), and amide (-NH-CO-) groups in the lactam ring are electron-rich, so they could easily donate electrons, hence making b-PEN a potential tribopositive material [52,53].…”

“…The electrical properties of b-PEN can be attributed to the presence of an amide group (-NH-CO-) in the lactam ring. In the chemical transition stage of b-PEN from its neutral molecular form to its anion form (as in its sodium salt), the dipole moment increased from 4.7 Debye to 18.2 Debye [49]. This specific chemical structure of b-PEN provides a specific surface charge distribution over the molecules, which could help enhance the electrical performance of the triboelectric nanogenerators when employed as tribopositive material.…”