Changes in the urinary proteome of rats after short-term intake of magnesium threonate

Shen, Ziyun; Yang, Minhui; Wang, Haitong; Liu, Yuqing; Gao, Youhe

doi:10.1101/2023.09.29.559957

Cited by 2 publications

(2 citation statements)

References 66 publications

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“…Our laboratory has previously reported that the urine proteome is able to reflect the effects of magnesium threonate intake on the body in a more systematic and comprehensive manner, with the potential to provide clues for clinical nutrition research and practice [3] . However, to date, there have been no studies exploring the effects of iron on the body from the perspective of the urine proteome.…”

Section: Introductionmentioning

confidence: 99%

Changes of urine proteome after intragastric administration of polysaccharide iron complex in rats

Shen,

Yang,

Wang

et al. 2024

Preprint

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Iron is an essential trace element to maintain the normal physiological function of organisms. In this study, the urine proteome of rats before and after short-term intragastric administration of polysaccharide-iron complex (28mg/kg/d iron, which is equivalent to the dose of anemia prevention in adults) was compared and analyzed by using two analysis methods: individual comparison and group comparison. Many different proteins were reported to be related to iron, including 2', 3' -cyclic nucleotide 3' -phosphodiesterase (CNPase) (7.7 times higher than that after gavage, p=0.0039), p38 (14.5 times higher than that before gavage, p=0.003), etc. In the individual comparison, Hepcidin was up-regulated in 4 rats simultaneously. The biological processes of differential protein enrichment include carbohydrate metabolism, iron ion reaction, apoptosis regulation, hematopoietic progenitor cell differentiation, etc. Molecular functions (e.g., complement binding, hemoglobin binding, etc.), KEGG pathways (e.g., complement and coagulation cascade, cholesterol metabolism, malaria, etc.) have also been shown to be associated with iron. This study contributes to the in-depth understanding of the biological function of iron from the perspective of urine proteomics, and provides a new research perspective for the prevention, diagnosis, treatment and monitoring of iron-related disorders.

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Section: Introductionmentioning

confidence: 99%

Changes of urine proteome after intragastric administration of polysaccharide iron complex in rats

Shen,

Yang,

Wang

et al. 2024

Preprint

Self Cite

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show abstract

“…The proteins in urine contain a wealth of information that can reflect small changes produced in different systems and organs of the organism. Our laboratory has previously reported that the urine proteome can reflect the effects of magnesium threonate intake on the body in a more systematic and comprehensive manner, and has the potential to provide clues for clinical nutrition research and practice [5] . To date, no studies have addressed the effects of complex nutrients on the urinary proteome of healthy adults.…”

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confidence: 99%

Changes in urinary proteome in healthy individuals taking multi-vitamin/mineral supplements

Shen,

Yang,

Wang

et al. 2024

Preprint

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Multivitamin/mineral supplements are widely used in many populations. Urine proteome has not been used to investigate its overall effects on healthy individuals. In this study, the urine proteome changed after taking compound nutrient supplements for 2 weeks and 4 weeks, and the differential proteins and their enriched pathways may be associated with nutrient supplementation. We noted that after taking the supplements for 2 weeks, the amount of erythropoietin receptor in urine was average 449 times higher than before, with four out of nine people experiencing changes from 0 to 14635, 11851, 11181, and 5930. The results of this study revealed that the urine proteome can provide new clues about the relatively short-term health effects of the supplements. It may help optimize guidelines and recommendations for the use of supplements.

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Changes in the urinary proteome of rats after short-term intake of magnesium threonate

Cited by 2 publications

References 66 publications

Changes of urine proteome after intragastric administration of polysaccharide iron complex in rats

Changes of urine proteome after intragastric administration of polysaccharide iron complex in rats

Changes in urinary proteome in healthy individuals taking multi-vitamin/mineral supplements

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