Changes in white spot lesions following post-orthodontic weekly application of 1.25 per cent fluoride gel over 6 months—a randomized placebo-controlled clinical trial. Part II: clinical data evaluation

Bock, Niko C.; Seibold, Laura; Heumann, Christian; Gnandt, Erhard; Röder, Miriam; Ruf, Sabine

doi:10.1093/ejo/cjw061

Cited by 7 publications

(4 citation statements)

References 46 publications

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“…Additional study visits were D30, D180 and D270. Standardized clinical photographs including a grey-scale in every picture for calibration were taken 15,[36][37][38][39] , oral hygiene, plaque index (according to Silness and Loe 1964 40 ), Nyvad Caries Activity Criteria 35 and laser fluorescence reading (Diagnodent Pen; KaVo) recorded as well as oral hygiene instructions provided at every study visit.…”

Section: Subjects All Clinical Procedures Were Performed At the Univmentioning

confidence: 99%

Efficacy of P11-4 for the treatment of initial buccal caries: a randomized clinical trial

Kondelova

Mannaa

Bommer

et al. 2020

Sci Rep

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To investigate the safety and efficacy of Self-Assembling Peptide P11-4 (SAP P11-4) compared to placebo or fluoride varnish (FV), a randomized, controlled, blinded, split-mouth study with sequential design was conducted. Subjects presenting two teeth with White-Spot-Lesions (WSLs) were included and teeth were randomly assigned to test or control. Control received placebo at baseline (D0) and test SAP P11-4, all received FV at Day 90 (D90). Standardized photographs were taken at each visit, and WSL size changes were morphometrically assessed. Hierarchical Linear Modelling, considering paired and sequential design, was used to test four hypotheses. SAP P11-4 lesions (test, D90–D0) showed significant WSL size reduction compared to placebo (control, D90–D0; p = 0.008) or FV (control, D180–D90; p = 0.001). Combination of SAP P11-4 and delayed FV after 90 days (test, D180–D0), showed a significant difference compared to FV alone (control D270–D90; p = 0.003). No significant difference on FV efficacy was found when SAP P11-4 was applied 3 months before FV (test D270–D90; control D270–D90, p = 0.70). SAP P11-4 treatment resulted in superior caries regression compared to either placebo or FV, and FV efficacy seems not to be affected by SAP P11-4. SAP P11-4 was found to be a safe and effective WSL treatment.

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Section: Subjects All Clinical Procedures Were Performed At the Univmentioning

confidence: 99%

Efficacy of P11-4 for the treatment of initial buccal caries: a randomized clinical trial

Kondelova

Mannaa

Bommer

et al. 2020

Sci Rep

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“…26,27 Twelve papers considered therapeutic strategies. Of these, seven studies were on remineralizing agents, [28][29][30][31][32][33][34] two studies were on resin infiltration, 35,36 one study evaluated the effectiveness of resin infiltration and microabrasion, 37 one study compared fluoride varnish and chlorhexidine mouthwash, and one study compared resin infiltration with varnish. 38 Table 3 demonstrates the general characteristics of the twenty-three included papers.…”

Section: Resultsmentioning

confidence: 99%

“…2,50 Despite the positive results of fluoride varnish, the effectiveness of using 1.25% fluoride gel for treatment of WSLs is not supported by the literature. 32,33 Application of ACP-CPP alone has not shown significant improvement of WSLs, although it is effective when combined with daily use of fluoride dentifrices. 29,31 Similar to fluoride varnish, resin infiltration has also shown successful results for the treatment of WSLs.…”

Section: Treatmentmentioning

confidence: 99%

Systematic review of preventive and treatment measures regarding orthodontically induced white spot lesions

Gholamrezayi,

Yazarloo,

Mirhashemi

et al. 2023

Dent. Med. Probl.

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White spot lesions (WSLs) are one of the most common adverse effects following comprehensive fixed orthodontic treatment. The purpose of this review was to evaluate recent studies addressing the prevention and treatment of these lesions. Electronic databases were searched for English-written studies published between 2015 and October 2020 involving randomized clinical trials aiming at prevention or treatment of orthodontically induced WSLs using the following keywords in their title or abstracts: randomized clinical trial OR randomized controlled trial AND white spot OR caries OR demineralization OR decalcification OR remineralization. From the 23 papers which met the inclusion criteria, 11 were on preventive methods, while 12 addressed treatment protocols. However, most of the reviewed studies had a high risk of bias. The results of this review strongly support the importance of oral hygiene observation in preventing WSLs. Sodium fluoride varnish 5% was confirmed to be effective in the treatment of these lesions, as well as in the prevention of WSLs in patients with suboptimal oral hygiene. In addition, immediate CO2 laser irradiation after bonding can effectively prohibit formation of WSLs during orthodontic treatment. The literature also illustrates a promising masking effect of resin infiltration for the treatment of WSLs. However, little scientific evidence supports the effectiveness of Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) against WSLs, although more clinical trials with long-term follow-up are needed. Oral hygiene maintenance is crucial in the prevention of WSLs, and 5% sodium fluoride varnish and CO2 laser irradiation are recommended in patients with compromised oral hygiene. In the case of WSL formation, fluoride varnish and resin infiltration are effective treatment modalities.

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“…The existing WSLs and caries around and under brackets are known to be a major problem during fixed orthodontic treatments and can result in causing increased costs, delays in the treatment, and irreversible loss of tooth tissues [ 6 , 7 ]. To overcome this obstacle, patients are required to use products that contain fluoride, chlorhexidine, or casein phosphopeptides-amorphous calcium phosphate (CPP-ACP) [ 8 , 9 , 10 , 11 , 12 ]. However, researchers have attempted to focus on preventive strategies that would be independent of patient cooperation, which include coating the brackets with antimicrobial nanoparticles [ 13 ] or the addition of antimicrobial or remineralizing agents to the orthodontic composites that are exerted to bond the brackets to a tooth [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Magnesium Oxide Nanoparticles Incorporation on Shear Bond Strength and Antibacterial Activity of an Orthodontic Composite: An In Vitro Study

et al. 2022

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This study aimed to evaluate the effects of magnesium oxide (MgO) nanoparticle (NP) incorporation on shear bond strength (SBS) and antibacterial property of orthodontic composites. A total of 100 mounted premolar teeth were randomly divided into five groups. In group 1 (control), the brackets were bonded to the teeth using the GC Ortho Connect orthodontic composite, while the brackets of groups 2 to 5 were bonded by the GC Ortho Connect orthodontic composite that contained 0.5%, 1%, 2%, and 4% weight percentages (w/w) of MgO NPs, respectively and then the SBS was measured. In the following, we evaluated the antibacterial properties of the MgO NP-containing composite on Streptococcus mutans (S. mutans) bacteria by the direct contact test method. According to results, there were no significant changes in the SBS as the MgO NP concentration was increased up to 1%, while the SBSs of the 2% and 4% MgO NPs were decreased when compared to the other three groups. The outcomes of the direct contact test indicated the case of 1% as being the minimum ratio of MgO NPs, which almost caused the entire annihilation of the S. mutans bacteria. In conclusion, the orthodontic composite containing 1% MgO NPs can display a significant antibacterial effect against S. mutans bacteria without inducing any negative effect on the SBS.

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Changes in white spot lesions following post-orthodontic weekly application of 1.25 per cent fluoride gel over 6 months—a randomized placebo-controlled clinical trial. Part II: clinical data evaluation

Abstract: The protocol wasn't published before trial commencement.

Cited by 7 publications

References 46 publications

Efficacy of P11-4 for the treatment of initial buccal caries: a randomized clinical trial

Efficacy of P11-4 for the treatment of initial buccal caries: a randomized clinical trial

Systematic review of preventive and treatment measures regarding orthodontically induced white spot lesions

Effects of Magnesium Oxide Nanoparticles Incorporation on Shear Bond Strength and Antibacterial Activity of an Orthodontic Composite: An In Vitro Study

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