Changes of Adrenergic Reaction Pattern in Experimental Diabetes Mellitus

Cseuz, Regina; Wenger, T.; Kunos, George; Szentiványi, M.

doi:10.1210/endo-93-3-752

Cited by 37 publications

(18 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, for the STZ-D rats, there were significant differences in sensitivity as a function of age and diabetes duration. For the 1A arterioles, sensitivity was normal (compared with age-matched ND rats) in all cases (2,4,8, and 16 wk after induction of diabetes), although there appeared to be a trend (not quite statistically significant at the 0.05 level) toward an increase in sensitivity after 16 wk. (As mentioned above, data were not obtained for 1A arterioles at 32 wk.)…”

Section: Resultsmentioning

confidence: 82%

“…To investigate the time course of the development of the observed responses, STZ-D rats were studied at various durations after the induction of diabetes (2,4,8,16, and 32 wk) and are designated STZ-2, STZ-4, etc. The ND rats used for comparison were age matched to the STZ-D rats and are identified as ND-2, ND-4, etc.…”

Section: Research Design and Methods Surgical Preparation And Inductimentioning

confidence: 99%

“…One theory has attributed certain functional microvascular changes to altered responsiveness of the vascular smooth muscle to circulating vasoactive agents (3,4). To investigate this theory, vascular reactivity to various vasoactive agents during diabetes has been measured in isolated vascular tissue (5)(6)(7)(8)(9)(10)(11)(12) and, to a lesser degree, in intact microvascular preparations in situ (13)(14)(15). The results obtained in these studies have varied considerably, some reporting increased, some decreased, and some unchanged vascular reactivity associated with diabetes.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Microvascular Reactivity to Norepinephrine at Different Arteriolar Levels and Durations of Streptozocin-Induced Diabetes

Morff

1990

Diabetes

View full text Add to dashboard Cite

Microvascular disease is a hallmark of diabetes. Although the etiology of diabetic microangiopathy remains to be elucidated, numerous studies in experimental animals and human diabetic patients have suggested that a change in vascular reactivity to vasoactive agents is a component of the pathophysiology. Most previous studies have utilized indirect methods to study the microcirculation or have conducted studies of responses in large vessels. This study was designed to directly study in an intact microvascular preparation the effects of streptozocin-induced diabetes (STZ-D) on microvascular reactivity. The responses of arterioles in the cremaster muscle of pentobarbital sodium-anesthetized rats to topically applied norepinephrine were measured in STZ-D rats of 2, 4, 8, 16, and 32 wk duration and in age-matched nondiabetic rats. Resting arteriolar diameters and mean arterial pressure were not affected by diabetes. In the STZ-D rats, larger (1A) arterioles were normally responsive after 2, 4, 8, and 16 wk of diabetes compared with nondiabetic rats. In contrast, the smaller 2A and 3A arterioles exhibited hypersensitivity to norepinephrine initially, but responses returned to normal sensitivity as the duration of diabetes progressed to the chronic stage. These results suggest that there are important functional changes in the responses of the microcirculation to norepinephrine that are associated with the development of diabetes and that these changes are anatomically specific and temporally dependent.

show abstract

Section: Resultsmentioning

confidence: 82%

Section: Research Design and Methods Surgical Preparation And Inductimentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Microvascular Reactivity to Norepinephrine at Different Arteriolar Levels and Durations of Streptozocin-Induced Diabetes

Morff

1990

Diabetes

View full text Add to dashboard Cite

show abstract

“…This hyperrespon siveness was exhibited also in vitro by isolated aortic strips obtained from alloxan-diabetic rabbits (12). In contrast, Christlieb (10) re ported no difference in systemic pressor re sponses to norepinephrine in alloxan-or streptozotocin-diabetic rats.…”

Section: Introductionmentioning

confidence: 90%

Cardiovascular Effects of Alloxan Diabetes in Normotensive and Spontaneously Hypertensive Rats

Cavaliere¹,

Taylor²,

Kerwin³

et al. 1980

Pharmacology

View full text Add to dashboard Cite

The diabetogenic effects of alloxan (50 mg/kg i.v.) were recorded for 6 weeks in normotensive (WKY) and spontaneously hypertensive (SHR) rats. While systolic blood pressure increased in diabetic WKY, SHR exhibited a reduction in systolic blood pressure over the 6-week period. Heart rate of treated SHR, but not WKY, was reduced significantly during the course of diabetes. 6 weeks postalloxan, the pressor responses to spinal cord stimulation and various vasoactive agents were significantly reduced in both diabetic groups as compared to their age-matched controls. However, in vitro preparations taken from diabetic and control WKY rats showed similar responsiveness to vasoactive agents. The data suggest that circulatory factors contribute to the decreased in vivo responsiveness.

show abstract

“…The relative reduction of muscle mass also may reduce the drug-induced contractility of intestine. However, increased reactivity of the vascular system to vasopressor has been demonstrated in diabetic animal models, demonstrating increased vascular responses to vasoactive agents, such as noradrenaline (BRoDY and DIXON, 1964;CSEUZ et al, 1973;OWEN and CARRIER, 1980;SCARBOROUGH and CARRIER, 1984;MACLEOD and MCNEILL, 1985;AGRAWAL et al, 1987). These differences in sensitivity to drugs between diabetic intestine and the vascular system might be due to the differences in innervation of the autonomic nervous system.…”

Section: Resultsmentioning

confidence: 99%

Acetylcholine and substance P responsiveness of intestinal smooth muscles in streptozotocin diabetic rats.

1988

View full text Add to dashboard Cite

We found previously that in in vitro tube form preparations of isolated intestine of streptozotocin (STZ) diabetic rats, frequency of spontaneous intraluminal pressure waves was significantly reduced in duodenum when compared with normal controls. In order to elucidate further the diabetic intestinal disorders, we examined the frequency and amplitude of spontaneous length changes and contractile responses to acetylcholine (ACh) and substance P (sP) in isolated intestinal segments of normal and experimental diabetic rats. In comparison with normal controls, we could confirm the significantly decreased frequency of spontaneous length changes in isolated longitudinal and circular muscle preparations of diabetic duodenum (1 month after STZ injection). Furthermore, amplitude of spontaneous length changes was significantly decreased in circular muscle preparations of duodenum, jejunum, and ileum but not in colon nor in longitudinal muscle preparations. Doseresponse curves revealed that both ACh and sP responses were significantly decreased in longitudinal and circular muscle preparations of diabetic duodenum, jejunum, and ileum but not in colon. Mechanisms of reduced contractility of diabetic intestinal smooth muscle in response to ACh and sP were discussed.

show abstract

Changes of Adrenergic Reaction Pattern in Experimental Diabetes Mellitus

Cited by 37 publications

References 0 publications

Microvascular Reactivity to Norepinephrine at Different Arteriolar Levels and Durations of Streptozocin-Induced Diabetes

Microvascular Reactivity to Norepinephrine at Different Arteriolar Levels and Durations of Streptozocin-Induced Diabetes

Cardiovascular Effects of Alloxan Diabetes in Normotensive and Spontaneously Hypertensive Rats

Acetylcholine and substance P responsiveness of intestinal smooth muscles in streptozotocin diabetic rats.

Contact Info

Product

Resources

About