Changes of blood D-dimer level after COVID-19 in patients with coronary heart disease

Abstract

Funding Acknowledgements Type of funding sources: None. Background Covid-19 was emerged in Wuhan and disseminated to the rest of the world. The virus may affect any kind of human organs. Aim of the study was to estimate the blood D-dimer level after Covid-19 in patients with coronary heart disease. Methods 65 patients who were undergone Covid-19 (mild to moderate severity) without coronary heart disease (CHD; Group 1; aged 42-76 years, mean age 56.8±13.5 years) and 65 patients with CHD who was affected with Covid-19 (Group 2; aged 45-72 years, mean age 57.4±12.8 years) have been enrolled in this prospective study. Baseline characteristics were collected when first admitted to the hospital due to Covid-19, and follow-up characteristics were collected when they admitted to our hospital for the rehabilitation after undergoing Covid-19 in 3 months. Baseline and follow-up anthropometric, laboratory and instrumental data were assessed. All statistical analysis were performed by STATA software. Results Mean blood D-dimer level significantly reduced in both groups (from 864 ng/mL to 475 ng/mL in the first group, P<0.05 vs. from 812 ng/mL to 452 ng/mL in the Group 2, P<0.05), however there were not observed statistically significant changes when compared to groups, P>0.05. In the first group mean D-dimer level tended to be higher in men, with high fibrinogen level, and older patients. In the second group, D-dimer level tended to be higher in patients with higher body mass index (BMI) with high fibrinogen level. In the first group in 31% of patients was observed high level of D-dimer (>500 ng/mL) after 3 months whereas in the second group elevated D-dimer level maintained in 28% of patients. Conclusion Elevated blood D-dimer level are common after Covid-19, however concomitant CHD does not effect on it. Further studies are needed to reveal mechanisms of it.

Distinct Features of Vascular Diseases in COVID-19

“…106 Several biomarkers are associated with myocardial injury during COVID-19 infection. 107,108 Myocardial injuries associated with COVID-19 result in elevated levels of high-sensitivity cardiac troponin I (cTnI) and N-terminal pro-brain natriuretic peptide (NT-proBNP). 109 High cTnI levels correlate with the severity of the disease.…”

Contemporary view on chronic limb ischemia

“…It is a vasodilator drug with an additional antiplatelet effect, mainly affecting the microcirculation. The antiplatelet effect is secondary, so it is possible to prescribe pentoxifylline in combination with other antiplatelet agents, antiplatelet drugs [15]. Petoxifylline is a first-line drug not only in the Russian Federation, but also in many countries around the world: in the United States, for many years, pentoxifylline was the only FDA-approved drug for the treatment of peripheral arterial disease.…”

Changes of the endothelial properties in patients with coronary artery disease after COVID-19

“…It should be borne in mind that in older people, who are most sensitive to coronavirus infection, in many cases, endothelial function is impaired even without additional viral influences. Damage to the endothelium can be due to many reasons, among which an important role is assigned to exogenous ones -injuries, chronic intoxication with psychoactive substances and heavy metal compounds [7,8,9,10], which in turn increase the risk of COVID-19 morbidity and further affect the severity of the infection [11,12,13]. In the work of E.E.…”