Changes of Dopamine Transporter Availability in Depressed Patients with and without Anhedonia: A &lt;sup&gt;123&lt;/sup&gt;I-N-&amp;#x03C9;-Fluoropropyl-Carbomethoxy-3β- (4-Iodophenyl)tropane SPECT Study

Camardese, Giovanni; Risio, Luisa De; Nicola, Marco Di; Pucci, L; Cocciolillo, Fabrizio; Bria, Pietro; Giordano, Alessandro; Janiri, Luigi; Giuda, Daniela Di

doi:10.1159/000368117

Cited by 20 publications

(23 citation statements)

References 51 publications

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“… 21 , 22 In addition, we hypothesized that if DAT methylation affects its expression and if peripheral DAT methylation is reflective of DAT methylation in the brain, then elevated peripheral DAT methylation will be associated with stronger alcohol cue-induced blood oxygenation level dependent responses in mesolimbic brain areas (that is, NAc and amygdala), and could predict alcohol relapse. Given previous findings of reduced DAT availability in depression, 18 , 19 we also expected elevated peripheral DAT methylation in AD patients with higher depression scores and greater negative reinforcement craving.…”

Section: Introductionmentioning

confidence: 66%

“… 16 As the DAT1 9 R allele has been associated with reduced DAT expression, 17 it may be that the allele leads to accumulation of synaptic DA, which results in increased reward processing. Lower striatal DAT availability has also been reported in patients with major depressive disorder, 18 , 19 possibly in response to reductions in DA neurotransmission.…”

Section: Introductionmentioning

confidence: 92%

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Effects of depressive symptoms and peripheral DAT methylation on neural reactivity to alcohol cues in alcoholism

et al. 2015

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In alcohol-dependent (AD) patients, alcohol cues induce strong activations in brain areas associated with alcohol craving and relapse, such as the nucleus accumbens (NAc) and amygdala. However, little is known about the influence of depressive symptoms, which are common in AD patients, on the brain’s reactivity to alcohol cues. The methylation state of the dopamine transporter gene (DAT) has been associated with alcohol dependence, craving and depression, but its influence on neural alcohol cue reactivity has not been tested. Here, we compared brain reactivity to alcohol cues in 38 AD patients and 17 healthy controls (HCs) using functional magnetic resonance imaging and assessed the influence of depressive symptoms and peripheral DAT methylation in these responses. We show that alcoholics with low Beck’s Depression Inventory scores (n=29) had higher cue-induced reactivity in NAc and amygdala than those with mild/moderate depression scores (n=9), though subjective perception of craving was higher in those with mild/moderate depression scores. We corroborated a higher DAT methylation in AD patients than HCs, and showed higher DAT methylation in AD patients with mild/moderate than low depression scores. Within the AD cohort, higher methylation predicted craving and, at trend level (P=0.095), relapse 1 year after abstinence. Finally, we show that amygdala cue reactivity correlated with craving and DAT methylation only in AD patients with low depression scores. These findings suggest that depressive symptoms and DAT methylation are associated with alcohol craving and associated brain processes in alcohol dependence, which may have important consequences for treatment. Moreover, peripheral DAT methylation may be a clinically relevant biomarker in AD patients.

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Section: Introductionmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 92%

Effects of depressive symptoms and peripheral DAT methylation on neural reactivity to alcohol cues in alcoholism

et al. 2015

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“…Molecular imaging studies in depression and anxiety disorders have shown abnormalities in both striatal DAT and D2/3 receptor binding. Most studies in major depressive disorder (MDD) have reported decreased striatal DAT binding compared to controls [40–42]. Reduced DAT binding has also been described in anxiety disorders, although less consistently [43, 44].…”

Section: Discussionmentioning

confidence: 99%

The relationship between the dopaminergic system and depressive symptoms in cervical dystonia

Zoons

Tijssen

Dreissen

et al. 2017

Eur J Nucl Med Mol Imaging

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PurposeCervical dystonia (CD) is associated with tremor/jerks (50%) and psychiatric complaints (17–70%). The dopaminergic system has been implicated in the pathophysiology of CD in animal and imaging studies. Dopamine may be related to the motor as well as non-motor symptoms of CD. CD is associated with reduced striatal dopamine D2/3 (D2/3) receptor and increased dopamine transporter (DAT) binding. There are differences in the dopamine system between CD patients with and without jerks/tremor and psychiatric symptoms.MethodsPatients with CD and healthy controls underwent neurological and psychiatric examinations. Striatal DAT and D2/3 receptor binding were assessed using [123I]FP-CIT and [123I]IBZM SPECT, respectively. The ratio of specific striatal to non-specific binding (binding potential; BPND) was the outcome measure.ResultsTwenty-seven patients with CD and 15 matched controls were included. Nineteen percent of patients fulfilled the criteria for a depression. Striatal DAT BPND was significantly lower in depressed versus non-depressed CD patients. Higher DAT BPND correlated significantly with higher scores on the Unified Myoclonus Rating Scale (UMRS). The striatal D2/3 receptor BPND in CD patients showed a trend towards lower binding compared to controls. The D2/3 BPND was significantly lower in depressed versus non-depressed CD patients. A significant correlation between DAT and D2/3R BPND was found in both in patients and controls.ConclusionsAlterations of striatal DAT and D2/3 receptor binding in CD patients are related mainly to depression. DAT BPND correlates significantly with scores on the UMRS, suggesting a role for dopamine in the pathophysiology of tremor/jerks in CD.

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“…Likewise, in a pre-clinical model of amphetamine-induced SCZ-like behavior, n-3 PUFAs dietary supplementation reduced behavioral deficits, cytokine release and enhanced the effects of combined antipsychotic and celecoxib drug treatment [134]. Since brain DHA deficiency may alter the expression of DA receptors in ventral striatum and contribute to hypofunctioning of mesolimbic DA system and anhedonia as observed in depression [22,[135][136][137], then prenatal or early postnatal deficits of brain n-3 PUFAs status may be a pivotal factor in depression pathogenesis.…”

Section: N-3 Pufas Serotonin Dopamine and Npdsmentioning

confidence: 99%

Dietary Fatty Acids and Microbiota-Brain Communication in Neuropsychiatric Diseases

Marrone

Coccurello

2019

Biomolecules

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The gut-brain axis is a multimodal communication system along which immune, metabolic, autonomic, endocrine and enteric nervous signals can shape host physiology and determine liability, development and progression of a vast number of human diseases. Here, we broadly discussed the current knowledge about the either beneficial or deleterious impact of dietary fatty acids on microbiota-brain communication (MBC), and the multiple mechanisms by which different types of lipids can modify gut microbial ecosystem and contribute to the pathophysiology of major neuropsychiatric diseases (NPDs), such as schizophrenia (SCZ), depression and autism spectrum disorders (ASD).

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Changes of Dopamine Transporter Availability in Depressed Patients with and without Anhedonia: A <sup>123</sup>I-N-ω-Fluoropropyl-Carbomethoxy-3β- (4-Iodophenyl)tropane SPECT Study

Abstract: We suppose that a hypofunction of the striatal dopaminergic system may be a 'state' feature of a depressive condition as a whole rather than anhedonia itself. On the other hand, some anhedonic features mainly represent an enduring trait that persists independently of mood state.

Cited by 20 publications

References 51 publications

Effects of depressive symptoms and peripheral DAT methylation on neural reactivity to alcohol cues in alcoholism

Effects of depressive symptoms and peripheral DAT methylation on neural reactivity to alcohol cues in alcoholism

The relationship between the dopaminergic system and depressive symptoms in cervical dystonia

Dietary Fatty Acids and Microbiota-Brain Communication in Neuropsychiatric Diseases

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