Changes of Serum Adiponectin and Glycated Albumin Levels in Gestational Diabetes Mellitus Patients and Their Relationship with Insulin Resistance

Abstract

<jats:p>Background: We aimed to investigate the changes of serum adiponectin and glycated albumin (GA) levels in gestational diabetes mellitus patients and their relationship with insulin resistance.&#x0D; Methods: Overall, 137 pregnant women were enrolled from Jinan City People's Hospital, Laiwu District, China from Jan 2015 to Jun 2018. Among them, 71 pregnant women with gestational diabetes mellitus were examined as diabetes group, and 66 normal pregnant women as normal pregnant women group. In addition, 58 normal non-pregnant women of childbearing age who were examined in our hospital during the same period were selected as a control group. The serum adiponectin and GA levels of the three groups were compared, and the relationship between serum adiponectin, GA levels and insulin resistance was analyzed.&#x0D; Results: The serum adiponectin level of pregnant women in gestational diabetes mellitus (GDM) group was significantly lower than that of normal pregnant women and control group (P=0.031, P=0.027). The serum GA level of pregnant women in GDM group was significantly higher than that of normal pregnant women and control group (P&lt;0.001). Pearson correlation analysis showed that GA was positively correlated with Fasting plasma glucose (FPG), Fasting insulin (FINS) and Insulin resistance index(HOMA-IR) levels (P&lt;0.001), while adiponectin was negatively correlated with FPG FINS and HOMA-IR levels (P&lt;0.001).&#x0D; Conclusion: Abnormal levels of serum GA and adiponectin are closely related to insulin resistance in patients with gestational diabetes mellitus. Detection of serum GA and adiponectin levels can diagnose gestational diabetes mellitus quickly and effectively.</jats:p>

Correlation of Serum Th1/Th2 Cytokines with Insulin Resistance in Gestational Diabetes Mellitus

“…Diabetes mellitus, a pervasive chronic disease, poses a substantial threat to public health, with type 2 diabetes mellitus (T2DM) being its primary manifestation, predominantly driven by IR. Recent insights suggest that Th1 cytokines may play a pivotal role in the development of insulin resistance [1][2][3][4][5][6] . This discussion explores the intricate relationship between serum Th1 cytokines and insulin resistance in diabetes.…”

“…The precise mechanism by which serum Th1 cytokines contribute to insulin resistance remains incompletely understood [8] . Nevertheless, multiple studies propose that these cytokines may influence the insulin sensitivity of adipose tissue by regulating the secretion of adipokines [9][10][11] . For instance, IFN-γ can stimulate adipocytes to release resistin, a recognized mediator of IR.…”

“…In the future, several advancements are anticipated in the treatment of insulin resistance in GDM [16][17][18] :…”

Nghiên cứu nồng độ và mối liên quan giữa adiponectin huyết thanh với đái tháo đường thai kỳ

“…Nghiïn cûá u cuã a taá c giaã Madhu nùm 2019 choå n àiïí m cùae t cuã a nöì ng àöå adiponectin úã thúâ i àiïí m ba thaá ng àêì u thai kyâ laâ 9,1 µg/ml ghi nhêå n nöì ng àöå adiponectin coá àöå nhaå y 100% vaâ àöå àùå c hiïå u laâ 95,6% trong viïå c dûå àoaá n ÀTÀTK [15]. Kïë t quaã nghiïn cûá u cuã a taá c giaã Wang thûå c hiïå n taå i Trung Quöë c nùm 2020 trïn 137 thai phuå (71 thai phuå ÀTÀTK vaâ 66 thai phuå bònh thûúâ ng) úã tuöí i thai 23 -28 tuêì n cho thêë y giaá trõ nöì ng àöå adiponectin trong chêí n àoaá n ÀTÀTK coá àöå nhaå y laâ 85,92%, àöå àùå c hiïå u laâ 63,64% vúá i AUC laâ 0,74 [16]. So vúá i chêí n àoaá n ÀTÀTK bùç ng nghiïå m phaá p dung naå p àûúâ ng, adiponectin coá veã laâ möå t dêë u êë n sinh hoå c hûá a heå n vò thai phuå seä khöng cêì n nhõn ùn vaâ ruá t maá u nhiïì u lêì n. Tuy nhiïn, chûa coá nghiïn cûá u naâ o àûa ra chñnh xaá c ngûúä ng giaá trõ naâ o cuã a nöì ng àöå adiponectin àïí dûå àoaá n hoùå c chêí n àoaá n ÀTÀTK.…”

Relationship Between Serum microRNA-372-3p and Glucose Transporter 4 Levels and Insulin Resistance in Gestational Diabetes Mellitus

“…Therefore, the prevention and treatment of GDM is of great importance to women's health. The prevalence of GDM in the Chinese population is about 12%-18% [1][2][3][4][5][6] . In recent years, with the increased incidence of glucose metabolism abnormalities in pregnancy, GDM has become a major factor affecting the health of both mother and child.…”