“…Hyperglycemia will lead to activation of sorbitol pathway, increase of protein enzymolysis glycosylation, which will lead to hyperplasia and hypertrophy of neurointima microvascular endothelial cells, thickening of basement membrane, increase of dispersion distance and short circuit of adventitia arteriovenous. In addition, due to the hyperfunction of platelets, rigidity of red blood cells, increased adhesiveness, and increased blood viscosity, the blood flow of neurotrophic vessels decreased, resulting in ischemia and hypoxia of the nerve intima, resulting in abnormal neural metabolism and structural damage and a series of clinical manifestations (Ye, 2000). The main component of puerarin, puerarin flavone, can reduce the blood viscosity, inhibit platelet aggregation, reduce the level of thromboxane A2 (TXA2), reduce the significantly increased plasma endothelin, angiotensin II, and renin activity, thus expanding the microarteries, improving microcirculation, increasing the blood flow of neurotrophic vessels, and improving the ischemic and hypoxic state of the neurointima (Lin, 2000).…”