Changing Age Distribution of Deep Venous Thrombosis In the United States

Abstract

1539 Background: Deep vein thrombosis (DVT) and pulmonary embolism (PE) are the major cardiovascular killers in the hospital setting. While there is increasing understanding of the public health importance of DVT there are limited data on the trends in the distribution of DVT in different age groups. Aim: The aim of this study was to study national trends in age distribution of DVT in patients over the age of 45 years in the last decade. Methods: We used the National Inpatient Sample (NIS) to analyze the epidemiology of hospitalizations in various age groups from 1997 – 2007. The NIS is a part of the Healthcare Cost and Utilization Project (HCUP) sponsored by the Agency for Health Care Research and Quality (AHRQ) and contains information from a 20% stratified sample of hospitals extrapolated to show the entire national utilization in United States. For our study we selected the following ICD-9 codes to represent DVT (ICD-9 codes 451.11, 451.19, 451.2, 451.81, 451.9, 453.40, 453.41, 453.42, 453.8, 453.9). For each hospitalization, NIS allows a total of up to 15 diagnostic entries. The entry in the diagnostic (DX) field 1 is called the Principal Diagnosis (PD) is the principal reason for admission and the entries between DX fields 1 and DX field 15 are called all-listed diagnoses and include the principal diagnosis plus additional conditions that coexist at the time of admission, or that develop during the stay. We derived at Secondary diagnoses (SD) by excluding PD of DVT from the list of AD. U.S. Population Census Bureau was used to calculate the change in population. Predictive Analytics Software, IBM PASW Statistics 18.0 data analysis tool were used for data mining and statistical analysis and least square regression analysis was used to calculate ‘p’ value. Result: From 1997 – 2007, Conclusion: These data describe for the first time, trends in the relative contribution of different age groups to the burden of DVT among hospitalized patients in the United States. The population between age group 45–64 years is growing symmetrically as a proportion of the total population, total hospitalized population and total hospitalized population with DVT. On the other hand the population 65–84 years of age is decreasing as a proportion of the total hospitalized population with DVT to an even greater degree than as a proportion of the total population and the total hospitalized population. The group over 85 years remains a disproportionately large contributor to the population with DVT. These data suggest the need for greater study of the distribution of DVT, the underlying causes and potential strategies to prevent DVT in different age groups Disclosures: No relevant conflicts of interest to declare.