Changing epidemiology of oral squamous cell carcinoma of the tongue: A global study

Abstract

This study suggests a general but not universal increase in the incidence of tongue SCC worldwide. In some regions of the world, we observed a shifting trend toward women and/or younger patients. © 2016 Wiley Periodicals, Inc. Head Neck 39: 297-304, 2017.

A novel prognostic model for tongue squamous cell carcinoma based on the characteristics of tumour and its microenvironment: iBD score

“…The survival of OSCC patients depends on how early the tumour is detected and where it is located, and the 5‐year overall survival rate (OSR) is approximately 60% . Oral tongue squamous cell carcinoma (TSCC), arising at the anterior two‐thirds of the tongue, has been rapidly increasing in incidence to become the most common malignancy diagnosed in the oral cavity, comprising 25–40% of oral carcinomas . TSCC has a much more aggressive clinical behaviour and a worse prognosis than other cancers of the oral cavity due to its unique histological structure, including rich lymphatic network and highly muscularised make‐up, which thus facilitates invasion and lymph node metastasis (LNM) .…”

Oral tongue squamous cell carcinoma survival as stratified by age and sex: A surveillance, epidemiology, and end results analysis

“…Public heath campaigns' increasing awareness about these exposure‐related cancers have resulted in a decrease in the overall incidence of oral cavity cancer; however, recent epidemiological studies have noted the increasing incidence of head and neck cancer among young adults, particularly tongue and oropharyngeal neoplasms . Ng et al performed a global meta‐analysis of available cancer registries to determine trends in the incidence of oral tongue cancer . Interestingly, they report an increasing incidence of oral tongue squamous cell carcinoma (OTSCC) in young patients in a subset of data registries, including Australia, Canada, Finland, Iceland, Ireland, Singapore, Sweden, as well as several states in the United States (Connecticut, Michigan, Hawaii, Iowa, New Mexico, California, and Washington) .…”

“…Interestingly, they report an increasing incidence of oral tongue squamous cell carcinoma (OTSCC) in young patients in a subset of data registries, including Australia, Canada, Finland, Iceland, Ireland, Singapore, Sweden, as well as several states in the United States (Connecticut, Michigan, Hawaii, Iowa, New Mexico, California, and Washington) . This trend was not found in datasets from Austria, Bulgaria, Denmark, Estonia, Norway as well as two states from the United States (Georgia and Utah) . Furthermore, a Surveillance, Epidemiology, and End Results (SEER) database study from 2011 noted an increasing trend in OTSCC in young adults, most pronounced in white females, with a 111.3% increase from 1975 to 2007 …”

Epidermal growth factor receptor detection in serum and saliva as a diagnostic and prognostic tool in oral cancer

“…Oral squamous cell carcinoma (OSCC) is the 11th most common tumor worldwide in males, with a relatively high incidence in both poorly and highly developed countries. The estimated burden of 300,373 cases in 2012 is projected to grow to 450,870 by 2030, partly because of the ageing population, and partly due to an increasing incidence in young subjects and females . Even in Europe and the United States, most OSCC are diagnosed at an advanced stage, despite the presence of long‐standing preexisting lesions and even earlier molecular changes.…”