Changing pattern of respiratory virus detections among school‐aged children in a small community – Dane County, Wisconsin, September to December 2022

Temte, Jonathan L.; Goss, Maureen; Bell, Cristalyne; Barlow, Shari; Temte, Emily; Bateman, Allen C.; Uzicanin, Amra

doi:10.1111/irv.13171

Cited by 6 publications

(7 citation statements)

References 10 publications

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“…A rebound of respiratory virus activity was observed in March and April 2023. Overall, our observation was similar to the change in seasonality in other geographical regions [ 9 , 10 , 11 , 12 ].…”

Section: Discussionsupporting

confidence: 90%

“…The timeline of a few of these countermeasures is given in Figure 1 . There were reports from a number of regions on the seasonality of respiratory viruses before and during the COVID-19 pandemic, revealing suppression of non-SARS-CoV-2, clinically important respiratory viruses during the period of unusual, global-scale pandemic intervention and their resurgence after ‘returning to normal life’ [ 9 , 10 , 11 , 12 ]. This knowledge provides valuable insights for better preparedness against future outbreaks and pandemics, which is especially important to healthcare providers for situation assessment and wise allocation of manpower and resources to cope with surges of clinical needs.…”

Section: Introductionmentioning

confidence: 99%

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The Seasonality of Respiratory Viruses in a Hong Kong Hospital, 2014–2023

Chan,

Yau,

et al. 2023

Viruses

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We reviewed the multiplex PCR results of 20,127 respiratory specimens tested in a hospital setting from January 2014 to April 2023. The seasonal oscillation patterns of 17 respiratory viruses were studied. Compared with 2014–2019, a prominent drop in PCR positivity (from 64.46–69.21% to 17.29–29.89%, p < 0.001) and virus diversity was observed during the COVID-19 pandemic, with predominance of rhinovirus/enterovirus, sporadic spikes of parainfluenza viruses 3 and 4, respiratory syncytial virus and SARS-CoV-2, and rare detection of influenza viruses, metapneumovirus, adenovirus and coronaviruses. The suppressed viruses appeared to regain activity from the fourth quarter of 2022 when pandemic interventions had been gradually relaxed in Hong Kong. With the co-circulation of SARS-CoV-2 and seasonal respiratory viruses, surveillance of their activity and an in-depth understanding of the clinical outcomes will provide valuable insights for improved public health measures and reducing disease burden.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

The Seasonality of Respiratory Viruses in a Hong Kong Hospital, 2014–2023

Chan,

Yau,

et al. 2023

Viruses

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“…From the late COVID-19 pandemic, a rebound in the activities of non-SARS-CoV-2 respiratory pathogens has been observed worldwide [ 19 , 20 , 21 , 22 , 23 , 24 ]. In clinical laboratories, the attention and resources have been shifting from SARS-CoV-2 detection to multiplex detection of SARS-CoV-2 plus other respiratory pathogens.…”

Section: Discussionmentioning

confidence: 99%

Clinical Evaluation of the BIOFIRE SPOTFIRE Respiratory Panel

Chan,

Ho,

Chan

et al. 2024

Viruses

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The BIOFIRE SPOTFIRE Respiratory (R) Panel is a novel, in vitro diagnostic PCR assay with 15 pathogen targets. The runtime is about 15 min which is the shortest among similar panels in the market. We evaluated the performance of the SPOTFIRE R Panel with 151 specimens, including 133 collected from the upper respiratory tract (URT), 13 from the lower respiratory tract (LRT) and 5 external quality assessment program (EQAP) samples. The respiratory specimens were enrolled throughout the first two post-COVID-19 influenza seasons in Hong Kong (March to December 2023). For URT specimens, full concordance was observed between the SPOTFIRE R Panel and the standard-of-care FilmArray Respiratory 2.1 plus Panel (RP2.1plus) for 109 specimens (109/133, 81.95%). After discrepant analysis, the SPOTFIRE R Panel identified more pathogens than the RP2.1plus in 15 specimens and vice versa in 3 specimens. The per-target negative and positive percentage agreement (NPA and PPA) were 92.86–100% except the PPA of adenovirus (88.24%). For LRT and EQAP samples, all results were fully concordant. To conclude, the performance of the SPOTFIRE R Panel was comparable to the RP2.1plus.

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“…Despite a smaller sample size during this time, ORCHARDS ARI surveillance continued and served as an important indicator of persisting seasonal pathogens, such as rhino/enterovirus and seasonal coronaviruses. As NPIs were relaxed, the OSD experienced a resurgence of respiratory virus activity in autumn 2022, followed by a peak in SARS-CoV-2 cases corresponding with the Omicron surge in January 2022 [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Descriptive Epidemiology of Pathogens Associated with Acute Respiratory Infection in a Community-Based Study of K–12 School Children (2015–2023)

Bell,

Goss,

Norton

et al. 2024

Pathogens

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School-based outbreaks often precede increased incidence of acute respiratory infections in the greater community. We conducted acute respiratory infection surveillance among children to elucidate commonly detected pathogens in school settings and their unique characteristics and epidemiological patterns. The ORegon CHild Absenteeism due to Respiratory Disease Study (ORCHARDS) is a longitudinal, laboratory-supported, school-based, acute respiratory illness (ARI) surveillance study designed to evaluate the utility of cause-specific student absenteeism monitoring for early detection of increased activity of influenza and other respiratory viruses in schools from kindergarten through 12th grade. Eligible participants with ARIs provided demographic, epidemiologic, and symptom data, along with a nasal swab or oropharyngeal specimen. Multipathogen testing using reverse-transcription polymerase chain reaction (RT-PCR) was performed on all specimens for 18 respiratory viruses and 2 atypical bacterial pathogens (Chlamydia pneumoniae and Mycoplasma pneumoniae). Between 5 January 2015 and 9 June 2023, 3498 children participated. Pathogens were detected in 2455 of 3498 (70%) specimens. Rhinovirus/enteroviruses (36%) and influenza viruses A/B (35%) were most commonly identified in positive specimens. Rhinovirus/enteroviruses and parainfluenza viruses occurred early in the academic year, followed by seasonal coronaviruses, RSV, influenza viruses A/B, and human metapneumovirus. Since its emergence in 2020, SARS-CoV-2 was detected year-round and had a higher median age than the other pathogens. A better understanding of the etiologies, presentations, and patterns of pediatric acute respiratory infections can help inform medical and public health system responses.

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Changing pattern of respiratory virus detections among school‐aged children in a small community – Dane County, Wisconsin, September to December 2022

Cited by 6 publications

References 10 publications

The Seasonality of Respiratory Viruses in a Hong Kong Hospital, 2014–2023

The Seasonality of Respiratory Viruses in a Hong Kong Hospital, 2014–2023

Clinical Evaluation of the BIOFIRE SPOTFIRE Respiratory Panel

Descriptive Epidemiology of Pathogens Associated with Acute Respiratory Infection in a Community-Based Study of K–12 School Children (2015–2023)

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