Changing patterns in gastric adenocarcinoma

Abstract

A retrospective study was performed on gastric cancer patients admitted to the Cancer Institute Hospital, Tokyo, during the periods 1961-65 (n = 1181) and 1980-84 (n = 1473). The aim of the study was to see whether changes had occurred in gastric cancer patients over the years with respect to histology and tumour localization and, if so, how they compared with reports from the West. The proportion of proximally localized primary tumour increased from 17 to 27 per cent (P = 0.008), and signet-ring cell carcinoma increased from 2 to 22 per cent (P less than 0.001). These changes were not relative with regard to the declining incidence of intestinal tumours, but absolute. Patients with proximally localized tumours were generally in a more advanced stage of disease than those with distally localized tumours, and thus had poorer survival rates. However, after stratifying into stages, the difference in survival disappeared. The survival rate of patients with signet-ring cell carcinoma was not significantly different from that of patients with other gastric tumours (P greater than 0.05). The discrepancy between the survival rates of Japanese and western gastric cancer patients is attributed by some authors to tumour-related factors. However, we believe that the similar trends found with regard to tumour localization and histology point towards comparable tumour behaviour in the two different geographical areas.

Nodal abdominal spread in adenocarcinoma of the cardia. Results of a multicenter prospective study

“…dissection of nodes in positions [1][2][3][4][5][6][7][8][9][10][11], and dissection at least of the lower mediastinal nodes, at the First Division of General Surgery, Verona University, at the Institute of Surgical Sciences, Siena University, and at the First Division of General Surgery, Forli Hospital, Italy during the period January 1994 to April 1998.…”

“…Recent studies reported in the literature have revealed that, despite the decreasing overall incidence of gastric cancer in Western countries, there has been an increase in adenocarcinomas localized in the proximal stomach, particularly at the level of the cardia [1][2][3][4][5].…”

Características histológicas y endoscópicas del cáncer gástrico diagnosticado en un hospital nacional del Callao, Perú

“…Sin embargo, en las últimas décadas se ha observado un incremento de la frecuencia de los tumores de cuerpo y fondo (cáncer gástrico proximal) y de la unión esófago-gástrica (7)(8)(9) , lo cual se sospecha está asociado al cambio en la prevalencia también del tipo histológico de cáncer gástrico hacia el tipo difuso (10,11) .…”

Clinicopathological Time Trends of 2569 Gastric Carcinomas in Japan During the Past 20 Years

“…Some authors have also reported the same trend in foreign countries. (Craanen, Dekker, et al, 1992;Devesa, Blot, et al, 1998;Popiela, Kulig, et al, 2002) Nakajima, et al, 1989;Inoue, Tajima, et al, 1993) Kaneko et al have also reported finding significant decreasing trends for most age groups for papillary and mucinous adenocarcinomas. Tubular adenocarcinomas (the well-differentiated type) have shown a decreasing trend only in younger age groups.…”