Changing serotype distribution and resistance patterns among pediatric nasopharyngeal pneumococci collected in Moscow, 2010–2017

Mayanskiy, Nikolay; Куличенко, Т. В.; Alyabieva, Natalia; Brzhozovskaya, Ekaterina; Ponomarenko, Olga; Savinova, Tatiana; Lazareva, Anna

doi:10.1016/j.diagmicrobio.2019.02.010

Cited by 15 publications

(15 citation statements)

References 26 publications

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“…High resistance to penicillin (non-meningitis breakpoints) was found in 1.6% (MIC > 2), and 34.1% of strains had intermediate resistance (MIC > 0.06 -<2). These data are similar to those found in numerous studies carried out in different scenarios [2,25,[37][38][39][40][41][42]. Other studies have published higher rates (about 40%) [5,24] and the lowest rate has been reported in Switzerland (16.8%) [36].…”

Section: Discussionsupporting

confidence: 91%

“…Resistance to TMS reached 27.7%, similar to Cyprus [40] and the United States of America [38], and lower than the values found by other authors (35-45%) [27,41,42].…”

Section: Discussionsupporting

confidence: 51%

“…In our study, we found a 33.1% resistance during the commercialization of PCV7, slightly lower than the rates published for other Spanish studies (40.5% and 37%) [20,43]. In other studies, a similar value can be found in Cyprus, among the Bedouins of Sokora, and in Russia [5,40,42] with higher resistance rates in France and the United States of America [2,38]. This is closely linked with the elevated consumption of macrolides [1,43,44].…”

Section: Discussioncontrasting

confidence: 46%

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Impact of Pneumococcal Vaccination in the Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy Children of the Murcia Region in Spain

et al. 2020

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Background: An epidemiological study of Streptococcus pneumoniae nasopharyngeal carriage in healthy children was carried out five years after the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13). Objectives: Study the impact of pediatric vaccination with PCV13, and other associated epidemiological factors on the status of nasopharyngeal carriage, the circulating pneumococcal serotypes, and the antibiotic susceptibility to more frequently used antibiotics. Methods: A multi-center study was carried out in Primary Health Care, which included 1821 healthy children aged 1 to 4 years old. All isolates were sent to the Spanish Pneumococcal Reference Laboratory for serotyping and antimicrobial susceptibility testing. Results: At least one dose of PCV13 had been received by 71.9% of children and carriage pneumococcal prevalence was 19.7%. The proportion of PCV13 serotypes was low (14.4%), with an observed predominance of non-vaccine serotypes, 23B, 11A, 10A, 35B/F, and 23A were the five most frequent. A high rate of resistance to penicillin, erythromycin, and trimethoprim sulfamethoxazole was found. Conclusions: A low proportion of PCV13 serotypes were detected, confirming the impact of pediatric vaccination for reducing the serotypes vaccine carriage. High resistance rates to clinically important antibiotics were observed.

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Section: Discussionsupporting

confidence: 91%

“…Resistance to TMS reached 27.7%, similar to Cyprus [40] and the United States of America [38], and lower than the values found by other authors (35-45%) [27,41,42].…”

Section: Discussionsupporting

confidence: 51%

Section: Discussioncontrasting

confidence: 46%

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Impact of Pneumococcal Vaccination in the Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy Children of the Murcia Region in Spain

et al. 2020

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“…Remarkably, a recently published study from Russia demonstrated a significant rise in resistance to oxacillin, erythromycin and clindamycin in disease-associated nasopharyngeal isolates in response to PCV-13 implementation. The growing resistance was explained by the expansion of MDR endemic clone ST143 with serotype 14 [59].…”

Section: Resistance To Antimicrobial Agentsmentioning

confidence: 99%

Epidemiological and molecular characterization of Streptococcus pneumoniae carriage strains in pre-school children in Arkhangelsk, northern European Russia, prior to the introduction of conjugate pneumococcal vaccines

et al. 2020

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Background The 13-valent Pneumococcal Conjugate Vaccine (PCV-13) was introduced in the National Immunization Programme (NIP) schedule in Russia in March 2014. Previously, the 7-valent Pneumococcal Conjugate Vaccine (PCV-7) was marketed in Russia in 2009 but has never been offered for mass vaccination. A carriage study was performed among children in Arkhangelsk in 2006. The objective was to determine the prevalence of carriage, serotype distribution, antimicrobial susceptibility and the molecular structure of Streptococcus pneumoniae strains before marketing and introduction of PCV-13. Methods A cross-sectional study was conducted on a cluster-randomized sample of children and a self-administrated questionnaire for parents/guardians. Nasopharyngeal samples were collected from 438 children younger than 7 years attending nurseries and kindergartens in the Arkhangelsk region, Russia. Detailed demographic data, as well as information about the child’s health, traveling, exposure to antimicrobials within the last 3 months and anthropometric measurements were collected for all study subjects. Variables extracted from the questionnaire were analysed using statistic regression models to estimate the risk of carriage. All pneumococcal isolates were examined with susceptibility testing, serotyping and multilocus sequence typing. Results The overall prevalence of asymptomatic carriage was high and peaking at 36 months with a rate of 57%. PCV-13 covered 67.3% of the detected strains. High rates of non-susceptibility to penicillin, macrolides and multidrug resistance were associated with specific vaccine serotypes, pandemic clones, and local sequence types. Nine percent of isolates represented three globally disseminated disease-associated pandemic clones; penicillin- and macrolide-resistant clones NorwayNT-42 and Poland6B-20, as well as penicillin- and macrolide-susceptible clone Netherlands3-31. A high level of antimicrobial consumption was noted by the study. According to the parent’s reports, 89.5% of the children used at least one antimicrobial regime since birth. None of the hypothesised predictors of S. pneumoniae carriage were statistically significant in univariable and multivariable logistic models. Conclusions The study identified a high coverage of the PCV-13-vaccine, but serotype replacement and expansion of globally disseminated disease-associated clones with non-vaccine serotypes may be expected. Further surveillance of antimicrobial resistance and serotype distribution is therefore required.

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“…Достаточно часто серотип 15А относится к пневмококкам с множественной лекарственной устойчивостью и имеет высокую резистентность к антибактериальным препаратам [24,25]. Некоторыми авторами отмечается, что в последние годы серогруппа 15 стала одной из наиболее распространенных серогрупп, не входящих в состав вакцины, среди пневмококков, вызывающих инвазивные пневмококковые инфекции, а также выделенных от носителей [26,27]. В работе российских ученых T. Savinova с соавт.…”

Section: характеристика серотипов пневмококка планируемых к включению...unclassified

Analysis of pneumococcal serotypes distribution to determine a model composition for a Russian pneumococcal conjugate vaccine

Трухин¹,

Evtushenko²,

Салимова³

et al. 2022

Biological Products. Prevention, Diagnosis, Treatment

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Diseases caused by Streptococcus pneumoniae, as well as antibiotic resistance of its serotypes, are the leading cause of death amongst children worldwide. To prevent pneumococcal infection, the population is immunised with conjugate vaccines containing different amounts of polysaccharides of certain serotypes. Development of a full-cycle Russian vaccine is vital because the active pharmaceutical ingredients for the vaccines registered in the Russian Federation are produced abroad, and only the final stages of production of vaccines of this group are performed in the territory of the Russian Federation. Considering the phenomenon of serotype replacement associated with the long-term widespread use of pneumococcal conjugate vaccines, it is necessary to carefully select the serotype composition for the new vaccine. The aim of this work was to analyse the serotype distribution of pneumococci in the Russian Federation and other countries in order to select optimal serotypes for the Russian vaccine for human use, taking into account vaccination schedules for each age group. This review presents an analysis of the pneumococcal serotype distribution in the Russian Federation in the pre-vaccination era, as well as after the introduction of routine vaccination. In addition, the review includes data on the serotype distribution in the Eurasian Economic Union countries. The authors described a model composition containing at least sixteen serotypes. It will increase effectiveness of immune protection of the population, providing a more complete coverage of serotypes, considering their prevalence in the Russian Federation. Based on the analysis, the serotype composition for the sixteen-valent pneumococcal conjugate vaccine is proposed for further production and preclinical and clinical trials. A new Russian pneumococcal conjugate vaccine will ensure vaccination of all population groups within the National Immunisation Schedule of the Russian Federation.

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Changing serotype distribution and resistance patterns among pediatric nasopharyngeal pneumococci collected in Moscow, 2010–2017

Cited by 15 publications

References 26 publications

Impact of Pneumococcal Vaccination in the Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy Children of the Murcia Region in Spain

Impact of Pneumococcal Vaccination in the Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy Children of the Murcia Region in Spain

Epidemiological and molecular characterization of Streptococcus pneumoniae carriage strains in pre-school children in Arkhangelsk, northern European Russia, prior to the introduction of conjugate pneumococcal vaccines

Analysis of pneumococcal serotypes distribution to determine a model composition for a Russian pneumococcal conjugate vaccine

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