Changing spectrum of the diffuse infiltrative lymphocytosis syndrome

Basu, Dhiman; Williams, Francis M.; Ahn, Chul; Reveille, John D.

doi:10.1002/art.21980

Cited by 82 publications

(79 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The authors believe that the increased effectiveness of HAART regimen could be the probable reason for the declining incidence of DILS. 16 In the present study, 9 (2.36%) subjects had cutaneous vasculitis with seven subjects having co-existent stroke, and CNS vasculitis was identified as the probable cause, after the excluding CNS opportunistic infections. Immunodeficiency is a risk factor for septic arthritis.…”

Section: Discussionmentioning

confidence: 47%

Prevalence of rheumatic manifestations in HIV patients: A cross-sectional study from Manipur, India

Naorem

Arvind

Bimol

et al. 2017

IJRCI

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 47%

Prevalence of rheumatic manifestations in HIV patients: A cross-sectional study from Manipur, India

Naorem

Arvind

Bimol

et al. 2017

IJRCI

View full text Add to dashboard Cite

“…An obstruction created by the lymphoid infiltration as described in the diffuse infiltrative lymphocytosis syndrome (DILS), may be reversed by the implementation of HAART. 23 The demonstration of lymphoid infiltration in the biopsy of the sublingual salivary gland (CD8 cells) might have been of great support to this theory on the etiopathogenesis of ranula in HIV-positive patients. However, it remains unclear at this stage, why are not all cases of ranula responding positively to the administration of HAART.…”

Section: Discussionmentioning

confidence: 91%

The potential impact of highly active antiretroviral therapy on the treatment and epidemiology of ranula in human immunodeficiency virus–positive patients

Syebele

Munzhelele

2013

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

View full text Add to dashboard Cite

“…Tissue infiltrates are predominantly composed of CD68+ macrophages. DILS usually associates CD8+ lymphocytosis and CD8+ lymphocytic visceral infiltration, predominantly affecting the salivary glands, lungs, and less frequently, other organs, including the kidney in less than 10% of cases (44)(45)(46)(47)(48). HIV patients with IRIS or DILS respond to corticosteroid therapy (49,50).…”

Section: Discussionmentioning

confidence: 99%

Tubulointerstitial Nephropathies in HIV-Infected Patients over the Past 15 Years

Zaidan

Lescure

Brochériou

et al. 2013

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

Summary Background and objectives The therapy and outcome of HIV infection have dramatically changed over the last 15 years, resulting in a change in renal complications. This study analyzed the characteristics of HIV-infected patients and biopsy-proven tubulointerstitial nephropathies to define disease patterns and therapeutic implications. Design, setting, participants, & measurements A clinico-pathologic retrospective study of 59 consecutive renal biopsies showing predominant tubular and/or interstitial lesions in HIV-infected patients referred to the nephrology department between 1995 and 2011 was performed. HIV-associated nephropathy and vascular diseases were excluded from the study. Results Tubulointerstitial nephropathies accounted for 26.6% of 222 native renal biopsies performed in HIV-infected patients. Two pathologic groups were analyzed, tubulopathy and interstitial nephritis, which represented 49% and 51% of tubulointerstitial nephropathies, respectively. Most patients presented with AKI (76.3%) and high-grade proteinuria (57.7%). Drug-related nephrotoxicity was the leading cause (52.5%). Alternative etiologies included infections (15.2%), dysimmune disorders (8.5%), malignancies (3.4%), and chronic (10.2%) and acute (10.2%) tubulointerstitial nephropathies of undetermined origin. Tubulopathy was strongly associated with antiretroviral drug toxicity (75.9%) and mostly caused by tenofovir (55.2%), which was associated with proximal tubular dysfunction (87.5%), overt Fanconi’s syndrome (37.5%), and nephrogenic diabetes insipidus (12.5%). Interstitial nephritis was associated with a broader spectrum of pathologic lesions and etiologies. Conclusions In this series, tubulointerstitial nephropathies accounted for 26.6% of renal diseases in HIV-infected patients. Considering the therapeutic implications of diagnoses of drug toxicity, infection, and dysimmune syndromes, this study underscores the importance of monitoring renal parameters in HIV-infected patients and points to the relevance of kidney biopsy to allow an accurate diagnosis.

show abstract

Changing spectrum of the diffuse infiltrative lymphocytosis syndrome

Abstract: Objective. To describe the changing clinical spectrum of patients with diffuse infiltrative lymphocytosis syndrome (DILS) after the introduction of highly active antiretroviral treatment (HAART), and to carry out HLA class II oligotyping in these patients.

Cited by 82 publications

References 20 publications

Prevalence of rheumatic manifestations in HIV patients: A cross-sectional study from Manipur, India

Prevalence of rheumatic manifestations in HIV patients: A cross-sectional study from Manipur, India

The potential impact of highly active antiretroviral therapy on the treatment and epidemiology of ranula in human immunodeficiency virus–positive patients

Tubulointerstitial Nephropathies in HIV-Infected Patients over the Past 15 Years

Contact Info

Product

Resources

About