Changing the Enzyme Reaction Rate in Magnetic Nanosuspensions by a Non‐Heating Magnetic Field

Klyachko, Natalia L.; Sokolsky-Papkov, Marina; Efremova, M. V.; Gulin, Dmitry A.; Pothayee, Nikorn; Kuznetsov, Artem A.; Majouga, Alexander G.; Riffle, Judy S.; Golovin, Yuri I.; Kabanov, Alexander V.

doi:10.1002/ange.201205905

Cited by 14 publications

(12 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A number of papers described the magnetomechanical activation of MNP through the application of LF AMF with the empirical choice of experimental parameters [ 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ]. Specifically, the authors of [ 51 ] mentioned the use of NMMA in regenerative medicine and tissue engineering, and the controlled release of DNA and other bioactive molecules from nanocontainers was pointed out in [ 44 , 125 ].…”

Section: Some Experimental Resultsmentioning

confidence: 99%

“…NMMA represents the other category of techniques that employ the nanoscale deformation of molecular structures by means of MNPs that are activated by non-heating low-frequency (LF) ( f < 1 kHz) AMF, and these techniques have been developed during the last two decades [ 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 ]. NMMA utilizes the sensitivity of tissue, cells, vesicles and micelles to applied forces and induced deformations [ 58 , 59 , 60 , 61 , 62 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Non-Heating Alternating Magnetic Field Nanomechanical Stimulation of Biomolecule Structures via Magnetic Nanoparticles as the Basis for Future Low-Toxic Biomedical Applications

Golovin

Vlasova

et al. 2021

Nanomaterials

Self Cite

View full text Add to dashboard Cite

The review discusses the theoretical, experimental and toxicological aspects of the prospective biomedical application of functionalized magnetic nanoparticles (MNPs) activated by a low frequency non-heating alternating magnetic field (AMF). In this approach, known as nano-magnetomechanical activation (NMMA), the MNPs are used as mediators that localize and apply force to such target biomolecular structures as enzyme molecules, transport vesicles, cell organelles, etc., without significant heating. It is shown that NMMA can become a biophysical platform for a family of therapy methods including the addressed delivery and controlled release of therapeutic agents from transport nanomodules, as well as selective molecular nanoscale localized drugless nanomechanical impacts. It is characterized by low system biochemical and electromagnetic toxicity. A technique of 3D scanning of the NMMA region with the size of several mm to several cm over object internals has been described.

show abstract

Section: Some Experimental Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Non-Heating Alternating Magnetic Field Nanomechanical Stimulation of Biomolecule Structures via Magnetic Nanoparticles as the Basis for Future Low-Toxic Biomedical Applications

Golovin

Vlasova

et al. 2021

Nanomaterials

Self Cite

View full text Add to dashboard Cite

show abstract

“…Так, приложенная сила и созданная ею деформация вызывает разнообразные отклики в живых клетках благодаря механотрансдукции [255], в частности, они меняют проницаемость клеточных мембран и метаболизм клетки, скорость ее роста и деления [253]. Силовое воздействие на биоактивные макромолекулы (ММ) ферментов влияет на их каталитическую активность [256,257]. В анализе взаимодействия различных тканей с имплантами необходимо учитывать весь комплекс биомеханических и физико-химических свойств контактирующих материалов и интерфейсов.…”

Section: разрушение в микро- субмикрои наношкалеunclassified

“…Г.Р. Державина и Университета Северной Каролины (США) запатентован и развит биомеханический подход к неинвазивной терапии нового поколения, заключающийся в селективной наномагнито-механическиой активации (NMMA) целевых биомолекулярных структур [256,257,[266][267][268][269][270]. Приложение принципов стрейнтроники -управления характеристиками материалов и нанообъектов посредством их контролируемой деформации -позволяет Force , N P 10 -13 10 -12 10 -11 10 -10 10 -9 10 -8 10…”

Section: разрушение в микро- субмикрои наношкалеunclassified

Наноиндентирование И Механические Свойства Материалов В Субмикро- И Наношкале. Недавние Результаты И Достижения (О Б З О Р)

Головин¹

2021

Физика Твердого Тела

View full text Add to dashboard Cite

The review discusses the details of various materials mechanical behavior in submicro- and nanoscale. Significant advances in this scope result from the development of wide family of load based precise nanotesting techniques called nanoindentation. But nowadays, nanomechanical properties are studied not only by nanoindentation techniques in narrow sense, i.e. local loading of macro, micro and nanoscale objects. Nanomechanical load testing is discussed here within a wider scope employing precise deformation measurement with nanometer scale resolution caused by various types of low load application to the object under study including uniaxial compression or extension, shearing, bending or twisting, optionally accompanied by in situ monitoring sample microstructure using scanning and transmission electron microscopy and Laue microdiffraction technique. The main courses of experimental techniques development in recent ten years along with the results obtained using them in single, poly and nano crystalline materials, composites, films and coatings, amorphous solids and such biomaterials as tissues, living cells and macromolecules are described. Special attention is paid to deformation size effects and atomic mechanisms in nanoscale. This review is a natural continuation and development of the review published at Fiz.Tverd.Tela vol.50, issue 12, 2008 of the same author that discusses details of nanomechanical properties of solids. Current review includes wider range of nanomechanical testing concepts and recent achievements in the scope. The work was supported by RFBR grant for project #19-12-50235.

show abstract

“…Despite the high biological and medical application potential of MNPs, studies on MNPs and magnetic field interaction have not been conducted sufficiently. The opinions on its influence also vary [13][14][15][16].…”

mentioning

confidence: 99%

Genetic Changes and Growth Promotion of Glioblastoma by Magnetic Nanoparticles and A Magnetic Field

Yang

Kang

Choi

et al. 2021

Nanomedicine (Lond.)

View full text Add to dashboard Cite

Aim: To confirm the biological effects of manganese ferrite magnetic nanoparticles (MFMNPs) and an external magnetic field on glioblastoma cells. Methods: U-87MG glioblastoma cells were prepared, into which the uptake of MFMNPs was high. The cells were then exposed to an external magnetic field using a neodymium magnet in vitro and in vivo. Results: LRP6 and TCF7 mRNA levels involved in the Wnt/β-catenin signaling pathway were elevated by the influence of MFMNPs and the external magnetic field. MFMNPs and the external magnetic field also accelerated tumor growth by approximately 7 days and decreased survival rates in animal experiments. Conclusion: When MFMNPs and an external magnetic field are applied for a long time on glioblastoma cells, mRNA expression related to Wnt/β-catenin signaling is increased and tumor growth is promoted.

show abstract

Changing the Enzyme Reaction Rate in Magnetic Nanosuspensions by a Non‐Heating Magnetic Field

Cited by 14 publications

References 25 publications

Non-Heating Alternating Magnetic Field Nanomechanical Stimulation of Biomolecule Structures via Magnetic Nanoparticles as the Basis for Future Low-Toxic Biomedical Applications

Non-Heating Alternating Magnetic Field Nanomechanical Stimulation of Biomolecule Structures via Magnetic Nanoparticles as the Basis for Future Low-Toxic Biomedical Applications

Наноиндентирование И Механические Свойства Материалов В Субмикро- И Наношкале. Недавние Результаты И Достижения (О Б З О Р)

Genetic Changes and Growth Promotion of Glioblastoma by Magnetic Nanoparticles and A Magnetic Field

Contact Info

Product

Resources

About