Changing Trends in Antimicrobial Resistance and Serotypes of Streptococcus pneumoniae Isolates in Asian Countries: an Asian Network for Surveillance of Resistant Pathogens (ANSORP) Study

Abstract

Antimicrobial resistance in

Changing trends in serotype distribution and antimicrobial susceptibility ofStreptococcus pneumoniaecausing invasive diseases in Central Thailand, 2009–2012

“…The similar results was reported by the ANSORP study in 2008-2009 that found low resistance rates to penicillin among pneumococcal isolates caused non-meningeal IPD (3.9%) but high resistance (57.5%) among meningeal isolates. 24 Therefore, penicillin should not be used as the empirical treatment in patients who may have meningeal involvement in this region. Resistance to fluoroquinolones was also low, 1.7%, 0.4%, 1.5%, and 13.4% for levofloxacin, moxifloxacin, gatifloxacin, and ciprofloxacin, respectively.…”

“…Among serotype 19A in the ANSORP study, 86.0% showed erythromycin resistance. 24 This association was observed in a study in southern Israel before the introduction of PCV7 that found increased rate of penicillin and erythromycinnonsusceptible serotype 6A and 19A isolated in children with otitis media which was temporally associated with increased use of azithromycin and oral cephalosporins. 25 The clear benefits of PCV have led to the increased inclusion of PCV into the national immunization programs of many countries.…”

“…(P < 0.001). 24 Contrary to North America, and Europe, most Asian countries that found increases in serotype 19A had low rates of PCV7 use. One of the reasons for the increased prevalence of 19A in Asian countries could be from widespread use of macrolides in clinical practice and clonal spread of macrolideresistant strains.…”

Antibiotic Resistance Patterns and Related Mobile Genetic Elements of Pneumococci and β-Hemolytic Streptococci in Thai Healthy Children

“…Although rate and pattern of antibiotic resistance vary according to geographic origin. Trend of antibiotic resistance rate did not seem to reduce in Asian countries, moreover most antibiotic-resistant streptococcal isolates were found to be resistant to more than one class of antibiotic [8]. These findings revealed high proportion of strains less susceptible to commonly prescribed drugs, especially beta-lactam, macrolide and tetracycline.…”

Avaliação dos efeitos da inflamação na infecção respiratória por<i> Streptococcus</i> <i>pneumoniae</i> em camundongos.

“…(Constenla, 2008). O uso de agentes antimicrobianos está entre as principais estratégias de combate as infecções pneumocócicas, porém a dificuldade em estabelecer um tratamento eficaz é devido ao surgimento de cepas resistentes a antibióticos, principalmente ß-lactâmicos (Kim et al, 2012;Moyo et al, 2012).…”