An emerging challenge of integrated communication and sensing is the extraction of weak sensing signals transmitted through an unknown non-stationary channel. In this work, we propose a weak signal extraction method with weak measurement. Taking advantage of time division multiplexing, we preliminarily estimate the channel via adjustable finite impulse response filter, further suppressing the interfering signal caused by background noises via spectrum shift. By subsequently using the time-varying phase estimation method via weak measurement, the real-time detection of weak signals in the non-stationary channel is achieved. We demonstrate via theoretical analysis and confirmatory experiment that our method is able to amplify the phase shift, to suppress technical noise and to improve detection resolution limit, while proving robust against light source fluctuations, initial phase differences and detector saturation. The method hence enables weak sensing signal extraction with a low signal-to-noise ratio non-stationary channel. Furthermore, we interface our measurement method to squeezed light sources, offering the possibility of surpassing standard quantum limit.