Chapter 11 Homeo Box Genes in Murine Development

Fienberg, Allen A.; Utset, Manuel F.; Bogarad, Leonard D.; Hart, Charles P.; Awgulewitsch, Alexander; Ferguson‐Smith, Anne C.; Fainsod, Abraham; Rabin, Mark; Ruddle, Frank H.

doi:10.1016/s0070-2153(08)60627-4

Cited by 55 publications

(32 citation statements)

References 84 publications

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“…Anterio-posterior gradient of Hox gene family is a well-known example (Fienberg et al, 1987) and it has become a fashion to discuss developmental mechanisms in a similar manner. But as we see in case of Wnt (Gavin et al, 1990) or Hedgehog (Fietz et al, 1994), the vertebrate equivalents of these segment polarity genes are not involved in anterio-posterior patterning of body segment but in dorso-ventral polarity of body axis.…”

Section: Somite Segmentation and Notch Signalmentioning

confidence: 99%

Notch in vertebrates - molecular aspects of the signal

Katsube

Sakamoto²

2005

Int. J. Dev. Biol.

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Notch is a receptor consisting of a single path transmembrane protein which is essential for stem cell regulation in both vertebrates and invertebrates. We have investigated the function of Notch signaling and found that ligands of the Notch receptor (Delta and Serrate) sometimes act as receptor modulators in a cell autonomous manner; the balance of their activity as ligands explains satisfactorily 'lateral inhibition' as well as 'lateral specification'. This model explains not only fly morphogenesis, but also the general regulation of stem cells. In vertebrates, members of a novel family of genes which encode small secretory proteins, CCN, were demonstrated to bind to Notch and stimulate signaling. This is not a ligand type binding, but rather a modifier of the protein structure of Notch, so as to form a macromolecular complex. This association may open up novel perspectives on Notch signaling, for instance in the movement of cells involved in somite segmentation or angiogenesis. Thus, a well-conserved signal such as Notch seems to have changed in function during the evolution of vertebrates.

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Section: Somite Segmentation and Notch Signalmentioning

confidence: 99%

Notch in vertebrates - molecular aspects of the signal

Katsube

Sakamoto²

2005

Int. J. Dev. Biol.

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“…Because experiments to trace the commitment of cells to specific fates in other systems, most notably spinal cord, have revealed key insights on the mechanisms underlying physiology and connectivity, defining the genes that specify different types of neurons in the cerebellar cortex and the cerebellar nuclei should provide insight on the development of the cerebellar system. During embryogenesis, the vertebrate hindbrain is transiently segmented into neural segments termed rhombomeres between embryonic day 8.5 (E8.5) to E9.5 in the mouse and stages 9 -12 in the chick (Fienberg et al, 1987;Fraser et al, 1990;Krumlauf et al, 1993). The borders of the rhombomeres align with the borders of expression of specific Hox genes (Wilkinson et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

Molecular Markers of Neuronal Progenitors in the Embryonic Cerebellar Anlage

Morales¹,

Hatten²

2006

J. Neurosci.

163

158

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The cerebellum, like the cerebrum, includes a nuclear structure and an overlying cortical structure. Experiments in the past decade have expanded knowledge beyond the traditional function of the cerebellum to include critical roles in motor learning and memory and sensory discrimination. The initial steps in cerebellar development depend on inductive signaling involving FGF and Wnt proteins produced at the mesencephalic/metencephalic boundary. To address the issue of how individual cerebellar cell fates within the cerebellar territory are specified, we examined the expression of transcription factors, including mammalian homologues of LIM homeodomaincontaining proteins, basic helix-loop-helix proteins, and three amino acid loop-containing proteins. The results of these studies show that combinatorial codes of transcription factors define precursors of the cerebellar nuclei, and both Purkinje cells and granule neurons of the cerebellar cortex. Examination of gene expression patterns in several hundred lines of Egfp-BAC (bacterial artificial chromosome) transgenic mice in the GENSAT Project revealed numerous genes with restricted expression in cerebellar progenitor populations, including genes specific for cerebellar nuclear precursors and Purkinje cell precursors. In addition, we identified patterns of gene expression that link granule and Purkinje cells to their precerebellar nuclei. These results identify molecular pathways that offer new insights on the development of the nuclear and cortical structures of the cerebellum, as well as components of the cerebellar circuitry.

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“…Homeodomain transcription factors drive development by regulating regional patterns of gene expression that control diverse cellular behaviors such as differentiation, proliferation, adhesion, migration and apoptosis (Fienberg et al, 1987;Mark et al, 1997). Homeobox genes can also contribute to breast cancer progression by influencing cell cycle regulation, apoptosis, angiogenesis and metastasis (Care et al, 2001;Samady et al, 2004;Satoh et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

BARX2 and estrogen receptor-α (ESR1) coordinately regulate the production of alternatively spliced ESR1 isoforms and control breast cancer cell growth and invasion

Stevens

Meech

2006

Oncogene

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The estrogen receptor-a gene (ESR1) was previously identified as a direct target of the homeobox transcription factor BARX2 in MCF7 cells. Here, we show that BARX2 and ESR1 proteins bind to different ESR1 gene promoters and regulate the expression of alternatively spliced mRNAs that encode 66 and 46 kDa ESR1 protein isoforms. BARX2 increases the expression of both ESR1 isoforms; however, it has a greater effect on the 46 kDa isoform, leading to an increased ratio between the 46 and 66 kDa proteins. BARX2 also influences estrogen-dependent processes such as anchorage-independent growth and modulates the expression of the estrogen-responsive genes SOX5, RBM15, Dynein and Mortalin. In addition, BARX2 expression promotes cellular invasion and increases the expression of active matrix metalloproteinase-9 (MMP9). BARX2 also increases the expression of the tissue inhibitor of metalloproteinase (TIMP) genes, TIMP1 and TIMP3, in cooperation with estrogen signaling. Overall, these data indicate that BARX2 and ESR1 may coordinately regulate cell growth, survival and invasion pathways that are critical to breast cancer progression.

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Chapter 11 Homeo Box Genes in Murine Development

Cited by 55 publications

References 84 publications

Notch in vertebrates - molecular aspects of the signal

Notch in vertebrates - molecular aspects of the signal

Molecular Markers of Neuronal Progenitors in the Embryonic Cerebellar Anlage

BARX2 and estrogen receptor-α (ESR1) coordinately regulate the production of alternatively spliced ESR1 isoforms and control breast cancer cell growth and invasion

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