Chapter 13. Recent Advances in Anti-Infective Agents

Hammond, Milton L.

doi:10.1016/s0065-7743(08)60883-0

Cited by 5 publications

(2 citation statements)

References 96 publications

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“…Among them we find the chelating α-amino acids [10], antibacterial nalidixic acid-derived quinolones [16], and probably kynurenic acid analogs acting as antagonists at the glycine site [17]. Thus, all arylacetic acids show more or less potent antiinflammatory activities, and many α-functionalized carboxylic acids are chelating agents.…”

Section: Acidic Solubilizing Chainsmentioning

confidence: 99%

Preparation of Water-Soluble Compounds by Covalent Attachment of Solubilizing Moieties

Wermuth¹,

Lesuisse²

2015

The Practice of Medicinal Chemistry

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Section: Acidic Solubilizing Chainsmentioning

confidence: 99%

Preparation of Water-Soluble Compounds by Covalent Attachment of Solubilizing Moieties

Wermuth¹,

Lesuisse²

2015

The Practice of Medicinal Chemistry

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“…Among them we fi nd the chelating α -amino acids 6 and antibacterial nalidixic acid-derived quinolones 7 and probably kynurenic acid analogs acting as antagonists at the glycine site. Thus, all arylacetic acids show more or less potent anti-infl ammatory activities and many α -functionalized carboxylic acids are chelating agents.…”

Section: Acidic Solubilizing Chainsmentioning

confidence: 99%

Preparation of Water-Soluble Compounds by Covalent Attachment of Solubilizing Moieties

Wermuth¹

2008

The Practice of Medicinal Chemistry

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β‐Lactam Antibiotics

Andreotti

Biondi

Modugno

2003

Burger's Medicinal Chemistry and Drug Discovery

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This chapter reviews the history of β‐lactams from the discovery of penicillin in 1928 to the more recently studied and the current trends in the field. The most relevant aspects related to the mechanism of action of β‐lactams are covered, and the various mechanisms of resistance to currently available β‐lactams that bacteria have adopted since the introduction of penicillin are described. A classification of β‐lactamases and their relevance in clinics is also provided. Applications of β‐lactams both in the hospital and in the community are reported, with particular attention to their pharmacokinetic properties, related side effects, and their therapeutic indications. The history and discovery of β‐lactams are described and all major classes are covered: penicillins, cephalosporins, oxacephems, carbacephems, penems, monobactams and nocardicins, carbapenems and trinems, classical (e.g., clavulanic acid, sulbactam, tazobactam), and the more recently disclosed β‐lactamase inhibitors. Several aspects related to the most recent developments in β‐lactams are also covered: new molecules active against difficult Gram‐positive strains or endowed with an antibacterial broad spectrum of action; potent orally active β‐lactams; injectable β‐lactams; and β‐lactamase inhibitors. The chapter concludes with a continuing analysis of the industry‐driven trends and the most recent new application of β‐lactams as inhibitors of protein export in bacteria. Finally, a few very interesting Web addresses and a comprehensive reference list are also provided.

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Chapter 13. Recent Advances in Anti-Infective Agents

Cited by 5 publications

References 96 publications

Preparation of Water-Soluble Compounds by Covalent Attachment of Solubilizing Moieties

Preparation of Water-Soluble Compounds by Covalent Attachment of Solubilizing Moieties

Preparation of Water-Soluble Compounds by Covalent Attachment of Solubilizing Moieties

β‐Lactam Antibiotics

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