Chapter 15 Decontamination and detoxification of mycotoxins

Leibetseder, J.

doi:10.1016/s1877-1823(09)70102-x

Cited by 13 publications

(10 citation statements)

References 145 publications

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“…Other physical methods of decontamination of maize grain such as removing spoiled kernels and floatation have been documented in literature (Shetty & Bhat, 1999;Sydenham, Van Der Westhuizen, Stockenstr€ om, Shephard, & Thiel, 1994). Chemical decontamination methods (Leibetseder, 2006;Mckenzie et al, 1997) have also been documented in literature but the safety and applicability of these methods to food intended for human consumption is highly debatable. While various decontamination procedures may be applied to maize and may contribute to decreased contamination and exposure, the critical issue becomes that of low-dose chronic exposure, particularly in regions such as in Sub-Saharan Africa where maize is a staple crop and this coupled with the fact that there are limited food choices.…”

Section: Co-occurrence Of Afb1 and Fb1mentioning

confidence: 99%

Review on the natural co-occurrence of AFB1 and FB1 in maize and the combined toxicity of AFB1 and FB1

et al. 2016

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Section: Co-occurrence Of Afb1 and Fb1mentioning

confidence: 99%

Review on the natural co-occurrence of AFB1 and FB1 in maize and the combined toxicity of AFB1 and FB1

et al. 2016

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“…The percentage of reduction in FB 1 in corn by single Ca(OH) 2 (nixtamalization) or with Na-HCO 3 + H 2 O 2 (modified nixtamalization), was 100% [178].…”

Section: Physical and Chemical Methodsmentioning

confidence: 99%

“…Although treatment with oxidizing agents is an economical method for detoxification of Fumonisin B 1 , this method isn't demonstrated in bioassays [178].…”

Section: Physical and Chemical Methodsmentioning

confidence: 99%

Metabolism, Toxicity, Detoxification, Occurrence, Intake and Legislations of Fumonisins - A Review

Farhadi

Nowrozi

Kachuei

2019

JPRI

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Fumonisins are a group of mycotoxins generated by the Fusarium spp. in foods and feeds. More than 15 isomers of Fumonisin are recognized, and the B series of Fumonisins is the primary and referral isomer of Fumonisin. Fumonisin B can cause leukoencephalomalacia in rabbits and horses and porcine pulmonary edema in swine. Fumonisin B is also nephrotoxic, hepatotoxic, immunotoxic and carcinogenic. It blocks sphingolipid biosynthesis (and hinders the synthesis of ceramide) by a noticeable resemblance to sphingosine and sphinganine. This paper provides a review of the toxicity, occurrence, and mechanism of carcinogenicity, hepatotoxicity, nephrotoxicity as well as immunotoxicity of Fumonisins, which are primarily found on a variety of food and feed in Africa, America, Europe, Asia, and Oceania. In this paper, current information on contamination of feeds and foods by Fumonisins around the world is summarized. Because of economic losses induced by Fumonisins and their harmful effects on animal and human health, various procedures to detoxify infected feeds and foods have been illustrated in this review, including biological, physical, and chemical processes. Additionally, we discuss dietary intakes and maximum limits of Fumonisins in some countries.

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“…The suitable storage of grains after harvest can also help to avoid increased DON contamination (Shapira et al, 2004). Physical methods, such as damaged grain removal, sieving, dehulling, radiation, and adsorbent use, were successful in detoxifying DON in cereal crops (Leibetseder, 2006). A wide variety of chemical methods have also been found to be effective against DON, including heating, alkaline hydrolysis, and oxidation (Young et al, 1986;He et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Biodegradation of Deoxynivalenol by a Novel Microbial Consortium

Wang

Dai

et al. 2020

Front. Microbiol.

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Deoxynivalenol (DON), a common mycotoxin of type B trichothecene, is produced mainly by several Fusarium species. DON causes great losses in farming and poses severe safety risks to human and animal health. Thus, DON contamination in cereals and DON toxicity are of worldwide concern. In this study, we screened the bacterial consortium C20, which efficiently degraded almost 70 μg ml −1 DON within 5 days. The bacterial consortium also had the ability to degrade 15-acetyl-DON, 3-acetyl-DON, and T-2 toxin. The bacterial consortium C20 was able to degrade DON under a wide range of pH and temperature conditions. The optimal temperature and pH for DON degradation were 30°C and pH 8.0, respectively. The bacterial consortium C20 comprised of different bacterial genera, and several strains were found to significantly increase when cultured in Mineral Medium with 100 μg ml −1 DON based on the analysis of the sequences of the hypervariable V3-V4 region of the 16S rRNA gene. 3-keto-DON was confirmed as a degradation product of DON by liquid chromatography/time-of-flight/mass spectrometry (LC-TOF-MS) and nuclear magnetic resonance (NMR) analyses. The results indicated that the bacterial consortium C20 is a potential candidate for the biodegradation of DON in a safe and environmentally friendly manner.

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Chapter 15 Decontamination and detoxification of mycotoxins

Cited by 13 publications

References 145 publications

Review on the natural co-occurrence of AFB1 and FB1 in maize and the combined toxicity of AFB1 and FB1

Review on the natural co-occurrence of AFB1 and FB1 in maize and the combined toxicity of AFB1 and FB1

Metabolism, Toxicity, Detoxification, Occurrence, Intake and Legislations of Fumonisins - A Review

Biodegradation of Deoxynivalenol by a Novel Microbial Consortium

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