Chapter 17. Steroids and Biologically Related Compounds

Morrow, Duane F.; Gallo, Duane G.

doi:10.1016/s0065-7743(08)60812-x

Cited by 2 publications

(9 citation statements)

References 106 publications

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“…The removal of this carbon atom results in an open or missing ring structure in the A ring of the steroid molecule. This modification alters the overall shape and properties of the steroid, leading to changes in its biological activity and pharmacological properties [18][19][20][21][22][23].…”

Section: A-norsteroids and Triterpenoids Derived From Marine Sourcesmentioning

confidence: 99%

“…These compounds have been investigated in various therapeutic areas, such as anti-inflammatory, anticancer, and hormonal therapies. Some examples of A-norsteroids include norethisterone (a synthetic progestin), nor-androstenedione (a precursor to the anabolic steroid nandrolone), and norbolethone (a synthetic anabolic steroid) [20][21][22][23].…”

Section: A-norsteroids and Triterpenoids Derived From Marine Sourcesmentioning

confidence: 99%

“…In Western Australia's ocean waters, sponges such as Agelas mauritiana, Clathria major, Darwinella australiensis, Didiscus aceratus, Haliclona sp., and Teichaxinella labirintica have been collected and analyzed for their steroid content [35]. From these sponges, approximately 60 different steroids were isolated, with A-norsteroids (17)(18)(19)(20)(21)(22)(23)(24)(25)(26) among them. Notably, extracts from Agelas mauritiana and Darwinella australiensis have displayed hemolytic activities [33][34][35][36].…”

Section: A-norsteroids and Triterpenoids Derived From Marine Sourcesmentioning

confidence: 99%

“…A range of 3β-hydroxy-methyl-A-norsterane steroids (69)(70)(71)(72)(73)(74)(75) was isolated from the Okinawan marine sponge Hymeniacidon aldis [58]. The sponge Hymeniacidon perlevis (order Halichondrina) was found to contain significant amounts of stanols with a 3β-hydroxymethyl-A-nor-sterane nucleus (18)(19)(20)(21)(22)(23)(24)(25), alongside sterols 28 and 70 [59].…”

Section: A-norsteroids and Triterpenoids Derived From Marine Sourcesmentioning

confidence: 99%

“…From Aspergillus wentii, meroterpenoids named asprethers A-E (546-550) were isolated and tested for cytotoxicity. These compounds showed effectiveness against the A549 cell line, with IC 50 values of 20,16,19,17, and 20 µM, respectively. Specifically, compound 546 exhibited higher activity against the T-47D cell line, while compound 547 was more effective against the HEK293 and SMMC-7721 cell lines [346].…”

Section: Modified D Ring In Steroidsmentioning

confidence: 99%

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Naturally Occurring Norsteroids and Their Design and Pharmaceutical Application

Dembitsky

2024

Biomedicines

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The main focus of this review is to introduce readers to the fascinating class of lipid molecules known as norsteroids, exploring their distribution across various biotopes and their biological activities. The review provides an in-depth analysis of various modified steroids, including A, B, C, and D-norsteroids, each characterized by distinct structural alterations. These modifications, which range from the removal of specific methyl groups to changes in the steroid core, result in unique molecular architectures that significantly impact their biological activity and therapeutic potential. The discussion on A, B, C, and D-norsteroids sheds light on their unique configurations and how these structural modifications influence their pharmacological properties. The review also presents examples from natural sources that produce a diverse array of steroids with distinct structures, including the aforementioned A, B, C, and D-nor variants. These compounds are sourced from marine organisms like sponges, soft corals, and starfish, as well as terrestrial entities such as plants, fungi, and bacteria. The exploration of these steroids encompasses their biosynthesis, ecological significance, and potential medical applications, highlighting a crucial area of interest in pharmacology and natural product chemistry. The review emphasizes the importance of researching these steroids for drug development, particularly in addressing diseases where conventional medications are inadequate or for conditions lacking sufficient therapeutic options. Examples of norsteroid synthesis are provided to illustrate the practical applications of this research.

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Section: A-norsteroids and Triterpenoids Derived From Marine Sourcesmentioning

confidence: 99%

Section: A-norsteroids and Triterpenoids Derived From Marine Sourcesmentioning

confidence: 99%

Section: A-norsteroids and Triterpenoids Derived From Marine Sourcesmentioning

confidence: 99%

Section: A-norsteroids and Triterpenoids Derived From Marine Sourcesmentioning

confidence: 99%

Section: Modified D Ring In Steroidsmentioning

confidence: 99%

See 3 more Smart Citations

Naturally Occurring Norsteroids and Their Design and Pharmaceutical Application

Dembitsky

2024

Biomedicines

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Naturally Occurring Nor-Steroids and Their Design and Pharmaceutical Application

Dembitsky

2024

Preprint

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The main focus of this review is to introduce readers to the fascinating class of lipid molecules known as norsteroids, exploring their distribution across various biotopes and their biological activities. The review provides an in-depth analysis of various modified steroids, including A, B, C, and D-norsteroids, each characterized by distinct structural alterations. These modifications, which range from the removal of specific methyl groups to changes in the steroid core, result in unique molecular architectures that significantly impact their biological activity and therapeutic potential. The discussion on A, B, C, and D-norsteroids sheds light on their unique configurations and how these structural modifications influence their pharmacological properties. The review also presents examples from natural sources that produce a diverse array of steroids with distinct structures, including the aforementioned A, B, C, and D-nor variants. These compounds, sourced from marine organisms like sponges, soft corals and starfish, as well as terrestrial entities such as plants, fungi, and bacteria. The exploration of these steroids encompasses their biosynthesis, ecological significance, and potential medical applications, highlighting a crucial area of interest in pharmacology and natural product chemistry. The review emphasizes the importance of researching these steroids for drug development, particularly in addressing diseases where conventional medications are inadequate or for conditions lacking sufficient therapeutic options. Examples of norsteroid synthesis are provided to illustrate the practical applications of this research.

show abstract

Chapter 17. Steroids and Biologically Related Compounds

Cited by 2 publications

References 106 publications

Naturally Occurring Norsteroids and Their Design and Pharmaceutical Application

Naturally Occurring Norsteroids and Their Design and Pharmaceutical Application

Naturally Occurring Nor-Steroids and Their Design and Pharmaceutical Application

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