Chapter 18 The Quinazoline Alkaloids

Openshaw, Harry

doi:10.1016/s1876-0813(08)60140-2

Cited by 6 publications

(4 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reagents used were from Merck (Darmstadt, Germany). In order to obtain standards of 1 and 2, dried powdered leaves (1 kg) of A. vasica were extracted with ethanol (Openshaw, 1953), the extract treated according to Gupta and Jain (1979), and an alkaloid fraction (2.4 g) isolated. This fraction was subjected to column chromatography over silica gel (Merck) using mixtures of chloroform and methanol of increasing polarity.…”

Section: Methodsmentioning

confidence: 99%

HPTLC determination of vasicine and vasicinone inAdhatoda vasica

2005

View full text Add to dashboard Cite

A simple high-performance thin-layer chromatographic (HPTLC) method has been developed for the simultaneous determination of the pharmacologically important quinazoline alkaloids vasicine and vasicinone in Adhatoda vasica. The assay combines the separation and quantification of the analytes on silica gel 60 GF254 HPTLC plates with visualisation under UV and scanning at 270 and 281 nm. Using this technique, the alkaloidal content of different parts of the title plant have been determined.

show abstract

Section: Methodsmentioning

confidence: 99%

HPTLC determination of vasicine and vasicinone inAdhatoda vasica

2005

View full text Add to dashboard Cite

show abstract

“…Quinazolin-4-ones 3 can be considered a privileged structure, prevalent in natural compounds . The quinazolin-4-one core can also be found in pharmaceuticals demonstrating hypnotic, antifungal, anticonvulsant, kinase inhibitory, or antimalarial activity (Figure ).…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Quinazolin-4-ones by Copper-Catalyzed Isocyanide Insertion

et al. 2020

View full text Add to dashboard Cite

Herein, we report a novel copper-catalyzed imidoylative cross-coupling/cyclocondensation reaction between 2-isocyanobenzoates and amines efficiently producing quinazolin-4-ones. The reaction utilizes Cu(II) acetate as an environmentally benign catalyst in combination with a mild base and proceeds well in anisole, a recommended, sustainable solvent. Additionally, the reaction does not require dry conditions or inert atmospheres for optimal performance. The scope of this isocyanide insertion reaction is rather broad, tolerating various functionalized isocyanobenzoates and a range of substituted amines, although the use of aromatic amines as nucleophiles requires microwave heating.

show abstract

“…include vasicine (syn. peganin), vasicinone and deoxyvasicinone [ 52 – 57 ]. Flavonoid glycosides and aglycons isolated from Linaria tissues include linarin, linarasin, acacetin, quercetin, acacetin monoglucoside, acacetin rhamnoside, and quercetin monoglucoside [ 58 – 61 ].…”

Section: Approachmentioning

confidence: 99%

Assessing Environmental Risks for Established Invasive Weeds: Dalmatian (Linaria dalmatica) and Yellow (L. vulgaris) Toadflax in North America

Sing

Peterson

2011

IJERPH

View full text Add to dashboard Cite

Environmental risk assessments characterizing potential environmental impacts of exotic weeds are more abundant and comprehensive for potential or new invaders than for widespread and well-established species such as Dalmatian (Linaria dalmatica [L.] Mill.) and yellow (L. vulgaris Mill.) toadflax. Specific effects evaluated in our assessment of environmental risks posed by yellow and Dalmatian toadflax included competitive displacement of other plant species, reservoirs of plant disease, animal and insect use, animal toxicity, human toxicity and allergenicity, erosion, and wildfire. Effect and exposure uncertainties for potential impacts of toadflax on human and ecological receptors were rated. Using publicly available information we were able to characterize ecological and human health impacts associated with toadflax, and to identify specific data gaps contributing to a high uncertainty of risk. Evidence supporting perceived negative environmental impacts of invasive toadflax was scarce.

show abstract

Chapter 18 The Quinazoline Alkaloids

Cited by 6 publications

References 38 publications

HPTLC determination of vasicine and vasicinone inAdhatoda vasica

HPTLC determination of vasicine and vasicinone inAdhatoda vasica

Synthesis of Quinazolin-4-ones by Copper-Catalyzed Isocyanide Insertion

Assessing Environmental Risks for Established Invasive Weeds: Dalmatian (Linaria dalmatica) and Yellow (L. vulgaris) Toadflax in North America

Contact Info

Product

Resources

About