Chapter 4. Iron-oxide Nanoparticle-based Contrast Agents

Stanicki, Dimitri; Elst, Luce Vander; Müller, Robert N.; Laurent, Sophie; Felder‐Flesch, Delphine; Mertz, Damien; Parat, Audrey; Cotin, Geoffrey; Grenèche, Jean‐Marc; Ersen, Ovidiu; Pichon, Benoît P.; Socoliuc, Vlad; Kuncser, V.; Turcu, Rodica; Vékás, L.; Foster, Paula J.; Bartha, Robert

doi:10.1039/9781788010146-00318

Cited by 9 publications

(9 citation statements)

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“…This facilitates treatment planning, the modeling of the heating process and quality assurance. MNPs can act as contrast agents in MRI (theranostic action) [ 151 , 202 ]. The MNPs can be used as temperature probes, thus providing non-invasive, real-time, 3D temperature distribution [ 203 , 204 ].…”

Section: Discussion and Perspectivesmentioning

confidence: 99%

Magnetic Hyperthermia and Radiation Therapy: Radiobiological Principles and Current Practice †

et al. 2018

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Hyperthermia, though by itself generally non-curative for cancer, can significantly increase the efficacy of radiation therapy, as demonstrated by in vitro, in vivo, and clinical results. Its limited use in the clinic is mainly due to various practical implementation difficulties, the most important being how to adequately heat the tumor, especially deep-seated ones. In this work, we first review the effects of hyperthermia on tissue, the limitations of radiation therapy and the radiobiological rationale for combining the two treatment modalities. Subsequently, we review the theory and evidence for magnetic hyperthermia that is based on magnetic nanoparticles, its advantages compared with other methods of hyperthermia, and how it can be used to overcome the problems associated with traditional techniques of hyperthermia.

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Section: Discussion and Perspectivesmentioning

confidence: 99%

Magnetic Hyperthermia and Radiation Therapy: Radiobiological Principles and Current Practice †

et al. 2018

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“…However, concerns have been raised regarding potential toxicity, non-specific biodistribution, poor cellular uptake and retention, and the sub-optimal contrast enhancement of GCs [ 7 , 68 , 69 ]. As a result, many improvements and alternatives to GCs have been developed [ 7 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 ].…”

Section: Imagingmentioning

confidence: 99%

“…In response to these issues, researchers have continued to develop IOP to reduce toxicity concerns, optimize magnetic properties and contrast performance, and apply them in novel and significant ways [ 65 , 66 , 72 , 73 , 74 , 75 , 86 , 88 ]. Here, we focus on the latter, and examine the current trends in IOP-based MRI.…”

Section: Imagingmentioning

confidence: 99%

Magnetic Nanoparticles in Biology and Medicine: Past, Present, and Future Trends

et al. 2021

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The use of magnetism in medicine has changed dramatically since its first application by the ancient Greeks in 624 BC. Now, by leveraging magnetic nanoparticles, investigators have developed a range of modern applications that use external magnetic fields to manipulate biological systems. Drug delivery systems that incorporate these particles can target therapeutics to specific tissues without the need for biological or chemical cues. Once precisely located within an organism, magnetic nanoparticles can be heated by oscillating magnetic fields, which results in localized inductive heating that can be used for thermal ablation or more subtle cellular manipulation. Biological imaging can also be improved using magnetic nanoparticles as contrast agents; several types of iron oxide nanoparticles are US Food and Drug Administration (FDA)-approved for use in magnetic resonance imaging (MRI) as contrast agents that can improve image resolution and information content. New imaging modalities, such as magnetic particle imaging (MPI), directly detect magnetic nanoparticles within organisms, allowing for background-free imaging of magnetic particle transport and collection. “Lab-on-a-chip” technology benefits from the increased control that magnetic nanoparticles provide over separation, leading to improved cellular separation. Magnetic separation is also becoming important in next-generation immunoassays, in which particles are used to both increase sensitivity and enable multiple analyte detection. More recently, the ability to manipulate material motion with external fields has been applied in magnetically actuated soft robotics that are designed for biomedical interventions. In this review article, the origins of these various areas are introduced, followed by a discussion of current clinical applications, as well as emerging trends in the study and application of these materials.

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“…A scientific method to adjust the toxicity of nano-sized materials is to apply biocompatible coatings such as polysiloxane, alginate, citric acid etc. to the surface [15,16]. A study by Laznev et al revealed that, there were no significant difference in the cytotoxicity of CoFe 2 O 4 and polysiloxane surface coated CoFe 2 O 4 nanoparticles [17].…”

Section: Introductionmentioning

confidence: 98%

Structural, optical, magnetic, photocatalytic activity and related biological effects of CoFe2O4 ferrite nanoparticles

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et al. 2021

J Mater Sci: Mater Electron

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Chapter 4. Iron-oxide Nanoparticle-based Contrast Agents

Cited by 9 publications

References 0 publications

Magnetic Hyperthermia and Radiation Therapy: Radiobiological Principles and Current Practice †

Magnetic Hyperthermia and Radiation Therapy: Radiobiological Principles and Current Practice †

Magnetic Nanoparticles in Biology and Medicine: Past, Present, and Future Trends

Structural, optical, magnetic, photocatalytic activity and related biological effects of CoFe2O4 ferrite nanoparticles

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