Chapter 8. Potassium Channel Activators

3-O-alkylascorbic acids as free radical quenchers. 3. Protective effect on coronary occlusion-reperfusion induced arrhythmias in anesthetized rats

“…The compounds 1-14 were prepared as described in our previous report.13® Initially, 5,6-O-isopropylideneascorbic acid (20) was reacted with alkyl halides in NaHC03/ DMSO, yielding 3-0-alkyl-5,6-0-isopropylideneascorbic 7 Nippon Hypox Laboratory. acids la-14a that gave compounds 1-14 after acid hydrolysis.…”

“…Recently we have described several series of novel antihypertensive agents based on the 4-(2-oxopyrrolidinl-yl)-2H-l-benzopyran-3-ol cromakalim (l),1 23'4 5which has been shown to hyperpolarize the membrane potential of vascular smooth muscle cells® via enhanced efflux of potassium ions6 through ATP-sensitive channels. 7 The net effect of this process is to relax blood vessels and reduce blood pressure.8…”

“…Bull. 1991,39(7), 1731. (14) Bharucha, K. R.; Cross, C. K.; Rubin, J. J. Long-Chain Acetals of Ascorbic and Erythorbic Acids as Antinitrosamine Agents.…”

Synthesis and antihypertensive activity of 3-[(substituted-carbonyl)amino]-2H-1-benzopyrans

“…Recently we have described several series of novel antihypertensive agents based on the 4-(2-oxopyrrolidinl-yl)-2H-l-benzopyran-3-ol cromakalim (l),1 23'4 5which has been shown to hyperpolarize the membrane potential of vascular smooth muscle cells® via enhanced efflux of potassium ions6 through ATP-sensitive channels. 7 The net effect of this process is to relax blood vessels and reduce blood pressure. 8 Since the discovery9 of cromakalim (1) a number of other compounds such as pinacidil (2) and RP 49356 (3) have been reported10 to be potassium channel activators.…”

“…8 Since the discovery9 of cromakalim (1) a number of other compounds such as pinacidil (2) and RP 49356 (3) have been reported10 to be potassium channel activators. Sev- WAY 120491 (7) EMD 57283 (8) Figure 1.…”