Chapter 9. Stapled Peptide Inhibitors of Protein–Protein Interactions

Drug discovery by targeting the protein–protein interactions involved in autophagy

“…For example, mixed-lineage leukemia (MLL) fusion proteins directly interact with menin protein, driving the leukemogenesis in MLL leukemia 8 . As a result, PPIs represent an important and attractive target class for pharmacological intervention 9 , 10 , 11 , 12 , 13 , 14 . Encouragingly, decades of efforts into molecular biology, biochemistry, structural biology and medicinal chemistry have expanded the cases in the field of PPI drug discovery 15 , 16 .…”