Characterisation of polyamide 11/copper antimicrobial composites for medical device applications

Thokala, Nikhil; Kealey, Carmel; Kennedy, James E.; Brady, Damien; Farrell, Jay A.

doi:10.1016/j.msec.2017.03.149

Cited by 31 publications

(12 citation statements)

References 26 publications

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“…It has been established that inorganic biocides have a reinforcing effect on the polyamide matrix caused by the formation of strong interfacial interactions, leading to a reduction in the mobility of polymer chains [22,39]. For example, heterogeneous PA-11/Cu antimicrobial nanocomposites showed an increase of the yield strength from 45 to 54 MPa when 2–10% of a copper additive was introduced [22]. The introduction of 5% of cationic biocide intercalated organoclay into PA-6 improved the yield strength by 44.6% [39].…”

Section: Resultsmentioning

confidence: 99%

“…Even though the non-covalent association between the bioactive compounds and the polymer matrix has been a major advantage to optimise the antimicrobial performance [24,51], the question always remains: is the system contact-active or biocide-releasing? It was shown for antimicrobial polyamide nanocomposites containing silver- or copper-based inorganic biocides that they release Ag or Cu ions into the surrounding aqueous medium in a steady and prolonged manner [19,20,21,22]. At the same time, biocide release was detected neither for polylactides, polyamides or silicones containing hydrophobic PHMG salts [35,36,37,38] nor for PA-6 containing cationic biocide-modified organoclays [39].…”

Section: Resultsmentioning

confidence: 99%

“…Copper and its compounds have also emerged as promising antimicrobial additives for polyamides, being much cheaper than silver. Thus, a commercially available ionic copper-based additive, Plasticopper, was incorporated into the PA-11 matrix during the polymer processing stage [22]. The incorporation of 5% and 10% copper was found to have a reinforcing effect on the composites and did not adversely affect their mechanical performance.…”

Section: Introductionmentioning

confidence: 99%

“…The incorporation of 5% and 10% copper was found to have a reinforcing effect on the composites and did not adversely affect their mechanical performance. These composite systems showed long-term antimicrobial activity against Gram-negative bacteria ( E. coli ) with a reduction of the bacterial population of more than 99.99% [22].…”

Section: Introductionmentioning

confidence: 99%

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Antibiofilm Activity of Polyamide 11 Modified with Thermally Stable Polymeric Biocide Polyhexamethylene Guanidine 2-Naphtalenesulfonate

Moshynets

Bardeau

Tarasyuk

et al. 2019

IJMS

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The choice of efficient antimicrobial additives for polyamide resins is very difficult because of their high processing temperatures of up to 300 °C. In this study, a new, thermally stable polymeric biocide, polyhexamethylene guanidine 2-naphtalenesulfonate (PHMG-NS), was synthesised. According to thermogravimetric analysis, PHMG-NS has a thermal degradation point of 357 °C, confirming its potential use in joint melt processing with polyamide resins. Polyamide 11 (PA-11) films containing 5, 7 and 10 wt% of PHMG-NS were prepared by compression molding and subsequently characterised by FTIR spectroscopy. The surface properties were evaluated both by contact angle, and contactless induction. The incorporation of 10 wt% of PHMG-NS into PA-11 films was found to increase the positive surface charge density by almost two orders of magnitude. PA-11/PHMG-NS composites were found to have a thermal decomposition point at about 400 °C. Mechanical testing showed no change of the tensile strength of polyamide films containing PHMG-NS up to 7 wt%. Antibiofilm activity against the opportunistic bacteria Staphylococcus aureus and Escherichia coli was demonstrated for films containing 7 or 10 wt% of PHMG-NS, through a local biocide effect possibly based on an influence on the bacterial eDNA. The biocide hardly leached from the PA-11 matrix into water, at a rate of less than 1% from its total content for 21 days.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Antibiofilm Activity of Polyamide 11 Modified with Thermally Stable Polymeric Biocide Polyhexamethylene Guanidine 2-Naphtalenesulfonate

Moshynets

Bardeau

Tarasyuk

et al. 2019

IJMS

View full text Add to dashboard Cite

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“…From this point of view, many research groups worldwide are intensively working on the development of effective solutions to this problem [ 3 , 4 , 5 ]. Most biomaterials used in healthcare facilities, which are often in direct contact with patients, are made of polymers, particularly polyamides [ 6 , 7 , 8 ]. The possibility of modifying these materials via chemical treatments provides these materials with added value and may thus improve patient care in the fight against infections caused by pathogenic bacterial strains and/or viruses.…”

Section: Introductionmentioning

confidence: 99%

The Covalent Tethering of Poly(ethylene glycol) to Nylon 6 Surface via N,N′-Disuccinimidyl Carbonate Conjugation: A New Approach in the Fight against Pathogenic Bacteria

2020

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Different forms of unmodified and modified Poly(ethylene glycols) (PEGs) are widely used as antifouling and antibacterial agents for biomedical industries and Nylon 6 is one of the polymers used for biomedical textiles. Our recent study focused on an efficient approach to PEG immobilization on a reduced Nylon 6 surface via N,N′–disuccinimidyl carbonate (DSC) conjugation. The conversion of amide functional groups to secondary amines on the Nylon 6 polymer surface was achieved by the reducing agent borane-tetrahydrofuran (BH3–THF) complex, before binding the PEG. Various techniques, including water contact angle and free surface energy measurements, atomic force microscopy, scanning electron microscopy, X-ray photoelectron spectroscopy, and Fourier-transform infrared spectroscopy, were used to confirm the desired surface immobilization. Our findings indicated that PEG may be efficiently tethered to the Nylon 6 surface via DSC, having an enormous future potential for antifouling biomedical materials. The bacterial adhesion performances against S. aureus and P. aeruginosa were examined. In vitro cytocompatibility was successfully tested on pure, reduced, and PEG immobilized samples.

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Effect of long‐chain branching molar fraction on scratch behavior of polypropylene

Tsai

Chang

Zhao

et al. 2021

J of Applied Polymer Sci

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Polymers containing a certain amount of long‐chain‐branching (LCB) structure are expected to possess improved mechanical properties over those of the linear structure counterpart. However, fundamental knowledge on the structure–property relationship in LCB containing polypropylene (PP) is still illusive. In the present study, a set of model PP systems containing an increasing molar fraction of LCB (5–19 mol%) were prepared by reactive extrusion to determine how LCB content may influence the scratch behavior of PP. It is shown that with only 5 mol% of LCB content in PP can improve resistance against scratch‐induced fish‐scale formation by over 25%. The improvement of scratch resistance is attributed to the increases in entanglement density in LCB‐containing PPs, which is evidenced by their creep‐recovery behavior. The present study demonstrates that the incorporation of LCB in PP leads to higher viscoelastic recovery and increased tensile strength, which account for the observed improvement in scratch performance. The usefulness of LCB in polymers for improving scratch performance is discussed.

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Characterisation of polyamide 11/copper antimicrobial composites for medical device applications

Cited by 31 publications

References 26 publications

Antibiofilm Activity of Polyamide 11 Modified with Thermally Stable Polymeric Biocide Polyhexamethylene Guanidine 2-Naphtalenesulfonate

Antibiofilm Activity of Polyamide 11 Modified with Thermally Stable Polymeric Biocide Polyhexamethylene Guanidine 2-Naphtalenesulfonate

The Covalent Tethering of Poly(ethylene glycol) to Nylon 6 Surface via N,N′-Disuccinimidyl Carbonate Conjugation: A New Approach in the Fight against Pathogenic Bacteria

Effect of long‐chain branching molar fraction on scratch behavior of polypropylene

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