Characterisation of the interactive properties of microcrystalline cellulose–carboxymethyl cellulose hydrogels

Zhao, Guangyao; Kapur, Nikil; Carlin, Brian; Selinger, Elizabeth; Guthrie, James T.

doi:10.1016/j.ijpharm.2011.05.054

Cited by 49 publications

(39 citation statements)

References 17 publications

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“…Tests that disrupt a gel may be of interest in tissue engineering applications and may be pursued after LVE characterization is complete. Nonlinear tests include fracture strength, steady shear, large‐amplitude oscillatory shear (LAOS), start‐up of steady shearing, and superposed shear and SAOS . Results from such tests would permit discussion of the relative strengths of different gels.…”

Section: Discussionmentioning

confidence: 99%

“…The SAOS measurement thus tracks the growth of the G ′ value from zero (sol) to the value of the equilibrium modulus G e . The same configuration may be used to monitor structural breakdown in hydrogels by imposing a nonlinear strain (large‐amplitude oscillatory shear, for example, or a proscribed amount of preshear) on the gel and subsequently monitoring the structural reformation with SAOS . Detailed characterization of the gelation point is also possible with SAOS, following the methods established by Chambon and coworkers .…”

Section: Introductionmentioning

confidence: 99%

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A protocol for rheological characterization of hydrogels for tissue engineering strategies

et al. 2013

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Hydrogels are studied extensively for many tissue engineering applications, and their mechanical properties influence both cellular and tissue compatibility. However, it is difficult to compare the mechanical properties of hydrogels between studies due to a lack of continuity between rheological protocols. This study outlines a straightforward protocol to accurately determine hydrogel equilibrium modulus and gelation time using a series of rheological tests. These protocols are applied to several hydrogel systems used within tissue engineering applications: agarose, collagen, fibrin, Matrigel™, and methylcellulose. The protocol is outlined in four steps: (1) Time sweep to determine the gelation time of the hydrogel. (2) Strain sweep to determine the linear-viscoelastic region of the hydrogel with respect to strain. (3) Frequency sweep to determine the linear equilibrium modulus plateau of the hydrogel. (4) Time sweep with values obtained from strain and frequency sweeps to accurately report the equilibrium moduli and gelation time. Finally, the rheological characterization protocol was evaluated using a composite Matrigel™-methylcellulose hydrogel blend whose mechanical properties were previously unknown. The protocol described herein provides a standardized approach for proper analysis of hydrogel rheological properties.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A protocol for rheological characterization of hydrogels for tissue engineering strategies

et al. 2013

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“…Avicel ® functions as a water-dispersible organic hydrocolloid that is primarily used for suspensions and emulsions. Avicel ® provides an emulsion or suspension with two primary attributes, namely a structured dispersion element and a protective element (12,13). Avicel ® was incorporated to determine the effect of an additional expedient to facilitate drug release.…”

Section: Introductionmentioning

confidence: 99%

“…Avicel ® was incorporated to determine the effect of an additional expedient to facilitate drug release. Avicel ® is a spray-dried mixture of carboxymethylcellose and microcrystalline cellulose (12,13).…”

Section: Introductionmentioning

confidence: 99%

Physicomechanical Characterization and Optimization of EDTA–mPEG and Avicel®–EDTA–mPEG In Situ Melt Dispersion Mini-Pellets

et al. 2013

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Abstract. The purpose of this study was to develop a physicomechanically customizable oral metal chelatory in situ hot melt dispersion mini-pellet entity which could be utilized within a binary drug delivery system. Avicel ® RC/CL type R-591 was included within the in situ hot melt dispersion mini-pellet formulations to determine the physicomechanical effect this compound would have on the mini-pellet formulations. The physicomechanical properties of the hot melt in situ mini-pellet formulations were mathematically fitting to regression curves. Physicomechanical adjustment of the in situ hot melt dispersion mini-pellet formulations could be mathematically predicted with the derived regression curve equations. The addition of Avicel ® RC/ CL type R-591 increased the physicomechanical properties such as matrix hardness and increased total disintegration of the in situ hot melt dispersion mini-pellet formulations. The utilization of a physicomechanically customizable oral metal chelatory in situ hot melt dispersion mini-pellet entity within a binary drug delivery system would to achieve a synergistically enhance the activity of a drug-carrying entity or a permeation enhancing entity within a single drug delivery unit. The experimental results indicated that weights of the pellets that achieved optimal hardness ranged between 35 and 45 mg. The melt-dispersion formulations disintegrated within shorter time periods and maintained higher ethylenediaminetetraacetic acid (EDTA) concentrations whereas melt-dispersion formulations which included Avicel ® had superior physicomechanical properties. Disintegration times ranged between 1,000 s for melt-dispersions containing EDTA and methyloxy polyethylene glycol 2000 (mPEG) only, to >6,000 s for melt-dispersions comprising EDTA, mPEG, and Avicel ® .

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“…A resistência da rede determina as propriedades físico-químicas do sistema hidrogel, e podem ser avaliadas pelo comportamento reológico (ZHAO et al, 2011).…”

Section: A Rede 3dunclassified

Caracterização físico-química de sistemas coloidais em sprays nasais

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Characterisation of the interactive properties of microcrystalline cellulose–carboxymethyl cellulose hydrogels

Cited by 49 publications

References 17 publications

A protocol for rheological characterization of hydrogels for tissue engineering strategies

A protocol for rheological characterization of hydrogels for tissue engineering strategies

Physicomechanical Characterization and Optimization of EDTA–mPEG and Avicel®–EDTA–mPEG In Situ Melt Dispersion Mini-Pellets

Caracterização físico-química de sistemas coloidais em sprays nasais

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