2001
DOI: 10.1002/1097-0177(2000)9999:9999<::aid-dvdy1083>3.0.co;2-e
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Characterisation ofHoxa gene expression in the chick limb bud in response to FGF

Abstract: We tested a diffusion gradient model for setting up overlapping domains of Hoxa gene expression in the chick limb bud. The model is based on morphogen production at the limb bud tip where the apical ridge is located and assumes that cells respond to a series of concentration thresholds. Consistent with the model, Hoxa13 gene expression rapidly switches off when the ridge is removed from stage 21/22 buds, while Hoxa11 and Hoxa10 expression is stable; Hoxa13 expression can be initiated and maintained in absence … Show more

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Cited by 40 publications
(37 citation statements)
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“…At this point it is constructive to examine another paradigm of Hox gene expressions after macroscopic manipulations at the embryonic level as performed in C. Tickle's Laboratory [9] hereafter denoted as (II). In a particular experiment on chick limb buds, this team excised the apical ectodermal ridge (AER) of the bud (II).…”
Section: Paradigm Of the Hoxa Expressions In The Chick Limb Budmentioning
confidence: 99%
See 2 more Smart Citations
“…At this point it is constructive to examine another paradigm of Hox gene expressions after macroscopic manipulations at the embryonic level as performed in C. Tickle's Laboratory [9] hereafter denoted as (II). In a particular experiment on chick limb buds, this team excised the apical ectodermal ridge (AER) of the bud (II).…”
Section: Paradigm Of the Hoxa Expressions In The Chick Limb Budmentioning
confidence: 99%
“…Then they examined the modified HoxA13 expression in the limb bud. The results are illuminating [9].…”
Section: Paradigm Of the Hoxa Expressions In The Chick Limb Budmentioning
confidence: 99%
See 1 more Smart Citation
“…is the tail position and x varies between 0 and x0 ( 0 ≤ x ≤ x0) [24]. In an experiment testing the time dependence of the morphogen (FGF) spreading in the chick limb bud, it is confirmed that diffusion is the responsible main mechanism [25].…”
Section: The Macro-and Micro-influences In the Biophysical Modelmentioning
confidence: 93%
“…To investigate if the 12-hour difference in developmental timing between quail and chick wings is associated with proximo-distal positional value specification, we analysed 5' (2,8,13,31) . Expression of Hoxa11 is detectable in the quail wing bud at 6 hours and in the chick at 12 hours (Fig.…”
Section: Proximo-distal Specification Is Faster In Quail Wings Comparmentioning
confidence: 99%