The Yellow River basin serves as an important economic belt and industrial base in China, featuring numerous industrial parks. However, alongside its economic significance, the basin struggles with significant water environmental challenges. This study analyzed the operational status, influent water quality, and energy consumption of 63 centralized wastewater treatment plants (WWTPs) from 54 major industrial parks in the Yellow River basin. The scale of these WWTPs was primarily within the range of 1 × 104~5 × 104 m3/d, with an average hydraulic loading rate of 53.8%. Aerobic treatment processes are predominant. The influent concentrations of chemical oxygen demand (COD), biochemical oxygen demand (BOD), ammonia nitrogen (NH3-N), total nitrogen (TN), and total phosphorus (TP) in the WWTPs exhibited a right-skewed distribution. The BOD/COD ratio of the WWTPs fluctuated between 0.1 and 1.6, and 75% of the WWTPs showed a COD/TN ratio lower than eight. The average BOD5/TN was 2.7, and the probability of influent BOD5/TP > 20 was 84.6%. A significant linear correlation exists between the influent BOD and COD concentrations, while moderate linear relationships are also observed among NH3-N, TN and TP, emphasizing the importance of maintaining appropriate nitrogen and phosphorus levels for efficient pollutant removal. The average electricity consumption of WWTPs in the Yellow River basin in 2023 was 1.1 kWh/m3. It is important to upgrade these WWTPs and reduce their energy consumption. Further strengthening the construction of industrial wastewater collection and treatment facilities based on regional characteristics is recommended to promote the high-quality development of industrial wastewater treatment in the Yellow River basin.