Characteristic spectral studies andin vitro Antimicrobial andin vivo multi-infection antifungal activities in mice of new organotin(IV) derivatives of heterocyclic amino acids

Nath, Mala; Yadav, Rakesh; Eng, George; Musingarimi, Primrose

doi:10.1002/(sici)1099-0739(199901)13:1<29::aid-aoc809>3.0.co;2-d

Cited by 56 publications

(4 citation statements)

References 40 publications

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“…Organotin compounds have been well-documented in their biocidal uses, but have also become of interest as cancer therapy [113–115]. A 2009 study examined the effect of two organotin compounds, triphenyltin (TPT) and tributyltin (TBT), on breast cancer cells [116].…”

Section: Natural Compounds and Repurposed Drugs With Proteasome-inhmentioning

confidence: 99%

Targeting the ubiquitin-proteasome system for cancer treatment: discovering novel inhibitors from nature and drug repurposing

Soave

Guerin

Liu

et al. 2017

Cancer Metastasis Rev

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In the past fifteen years, the proteasome has been validated as an anticancer drug target and 20S proteasome inhibitors (such as bortezomib and carfilzomib) have been approved by the FDA for the treatment of multiple myeloma and some other liquid tumors. However, there are shortcomings of clinical proteasome inhibitors, including severe toxicity, drug resistance and no effect in solid tumors. At the same time, extensive research has been conducted in the areas of natural compounds and old drug repositioning toward the goal of discovering effective, economical, low toxicity proteasome-inhibitory anticancer drugs. A variety of dietary polyphenols, medicinal molecules, metallic complexes and metal-binding compounds have been found to be able to selectively inhibit tumor cellular proteasomes and induce apoptotic cell death in vitro and in vivo, supporting the clinical success of specific 20S proteasome inhibitors bortezomib and carfilzomib. Therefore, the discovery of natural proteasome inhibitors and researching old drugs with proteasome inhibitory properties may provide an alternative strategy for improving the current status of cancer treatment and even prevention.

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Section: Natural Compounds and Repurposed Drugs With Proteasome-inhmentioning

confidence: 99%

Targeting the ubiquitin-proteasome system for cancer treatment: discovering novel inhibitors from nature and drug repurposing

Soave

Guerin

Liu

et al. 2017

Cancer Metastasis Rev

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“…found for organotin complexes with amino acids [17,18], thiols [19], o-phenanthroline, bipyridine, histidine, azomethines and carboxylates [13,[20][21][22][23], which are effective against various tumors.…”

Section: Of 13mentioning

confidence: 99%

New Catalysts Based on Carboxylate Sn(IV) Complexes Used in the Oxidation Reaction of 3,5-Di-Tert-Butylcatechol to 3,5- Di-Tert-Butyl-O-Benzoquinone

Titi¹,

Dahmani²,

Alzahrani³

et al. 2023

Preprint

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It is at the chemistry-biology interface that this work that we have carried out takes place. Indeed, the expected goal is to develop simple molecules, capable of activating the catalytic action of certain metalloenzymes such as tyrosinase. The official name of an enzyme includes the type of reaction catalyzed, the name of the substrates involved. In this work, we carried out the study of the catalytic activity of the complexes of organotin carboxylates synthesized vis-à-vis the oxidation of 3,5-di-tert-butylcatecchol. The results obtained show that the various complexes exhibit good catalytic activity for the oxidation of 3,5-di-tert-butylcatecchol under mild conditions. The complexes that showed good catalytic activity are the compounds C1 and C2.

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“…2 some time, organotin compounds have been studied for their antitumor activity [9]. Today, a number of interesting biological applications have been found for organotin complexes with amino acids [17,18], thiols [19], o-phenanthroline, bipyridine, histidine, azomethines and carboxylates [13,[20][21][22][23], which are effective against various tumors.…”

Section: Introductionmentioning

confidence: 99%

New catalysts based on carboxylate Sn(IV) complexes used in the oxidation reaction of 3,5-di-tert-butylcatechol to 3,5-di-tert-butyl-o-benzoquinone

Titi,

Dahmani,

Abbaoui

et al. 2023

Reac Kinet Mech Cat

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Characteristic spectral studies andin vitro Antimicrobial andin vivo multi-infection antifungal activities in mice of new organotin(IV) derivatives of heterocyclic amino acids

Cited by 56 publications

References 40 publications

Targeting the ubiquitin-proteasome system for cancer treatment: discovering novel inhibitors from nature and drug repurposing

Targeting the ubiquitin-proteasome system for cancer treatment: discovering novel inhibitors from nature and drug repurposing

New Catalysts Based on Carboxylate Sn(IV) Complexes Used in the Oxidation Reaction of 3,5-Di-Tert-Butylcatechol to 3,5- Di-Tert-Butyl-O-Benzoquinone

New catalysts based on carboxylate Sn(IV) complexes used in the oxidation reaction of 3,5-di-tert-butylcatechol to 3,5-di-tert-butyl-o-benzoquinone

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