Characteristics and Bone Tissue Reaction of Tetracalcium Phosphate-Collagen Conjugated Sponge

Comparative study on bone regeneration by synthetic octacalcium phosphate with various granule sizes

“…The OCP crystal assembly also has the potential to support the differentiation of rat bone marrow stromal cells into osteoblasts [15,16]. Although the solution-mediated and osteoclastic cell-mediated biodegradable properties of OCP could be one of the factors leading to higher osteoconduction in vivo [7,[17][18][19][20][21], it has been suggested that the transitory nature of OCP into HA in a physiological environment also plays a role in stimulating osteoblastic cells to differentiate both in vitro and in vivo during OCP-HA conversion [13,[22][23][24][25]. The osteoconductive characteristics of OCP were first demonstrated in granular form in the subperiosteal region of mouse calvaria [22,23], showing the rapid appearance of new bone more clearly than HA or Ca-deficient HA [22].…”

Reconstruction of Critical‐Sized Bone Defect in Dog Skull by Octacalcium Phosphate Combined with Collagen

“…23 However, unlike HA or b-TCP, OCP cannot be sintered because of the large number of water molecules in its structure. 6 However, the implanted OCP is resorbed by osteoclast-like cells [24][25][26] and is more resorbable than HA and b-TCP. 6 However, the implanted OCP is resorbed by osteoclast-like cells [24][25][26] and is more resorbable than HA and b-TCP.…”

“…The conversion from OCP to HA has been proved in some in vitro physiological environments, such as culture media, 19 simulated body fluid, 28 serum 29 and so forth. 25,35 OCP combined with collagen (OCP/collagen) has been shown to enhance bone regeneration more than OCP alone in a rat skull defect 35 or in rabbit bone marrow. 25,35 OCP combined with collagen (OCP/collagen) has been shown to enhance bone regeneration more than OCP alone in a rat skull defect 35 or in rabbit bone marrow.…”

“…9 b-TCP is a biodegradable ceramic and, therefore, is recognized as a material that is progressively replaced by bone. 6 However, the implanted OCP is resorbed by osteoclast-like cells [24][25][26] and is more resorbable than HA and b-TCP. 23 Synthetic OCP has been shown to convert to apatite when implanted in various sites, including muscle pouches, 27 the subperiosteal region of calvaria 17,18 and the subcutaneous region in mouse, 18 as well as critical-sized calvarial bone defects 19 in rat.…”

Effect of New Bone Substitute Materials Consisting of Collagen and Tricalcium Phosphate

“…The mechanism underlying the absorption of TCP particles probably involved phagocytosis of multinucleated giant cells, as suggested by many studies which found such particles were surrounded by multinucleated giant cells 13,15,20) . It is also possible that some particles were not phagocytized, but embedded in newly formed bone and consequently replaced with bone tissue.…”