Characteristics and progression of children with acute viral bronchiolitis subjected to mechanical ventilation

2020

BMC Health Serv Res

Background Pharmacological treatment for bronchiolitis is primarily supportive because bronchodilators, steroids, and antibiotics, show little benefit. Clinical studies have suggested that nebulized 3% hypertonic solution is useful for infants with bronchiolitis. This study aims to evaluate the cost-effectiveness of the HS inhalations in infant bronchiolitis in a tropical country. Methods Decision tree analysis was used to calculate the expected costs and QALYs. All cost and use of resources were collected directly from medical invoices of 193 patient hospitalized with diagnosis of bronchiolitis in tertiary centers, of Rionegro, Colombia. The utility values applied to QALYs calculations were collected from the literature. The economic analysis was carried out from a societal perspective. Results The model showed that nebulized 3% hypertonic solution, was associated with lower total cost than controls (US $200vs US $240 average cost per patient), and higher QALYs (0.92 vs 0.91 average per patient); showing dominance. A position of dominance negates the need to calculate an incremental cost-effectiveness ratio. Conclusion The nebulized 3% hypertonic solution was cost-effective in the inpatient treatment of infant bronchiolitis. Our study provides evidence that should be used by decision-makers to improve clinical practice guidelines and should be replicated to validate their results in other tropical countries.

Section: Methodsmentioning

confidence: 99%

The cost-effectiveness of hypertonic saline inhalations for infant bronchiolitis

Buendía

2020

BMC Health Serv Res

“…The computerized search yield 1021 citations and a total of 75 studies were examined. Finally, the information was extracted for the construction of the economic model of 10 studies that included patients less than 18 years of age, with bronchiolitis, and with use of HS (7,(13)(14)(15)(16)(17)(18)(19). Information regarding the effect of HS was extracted from a recent meta-analysis (11,16) which compared HS nebulization versus normal saline inhalations or standard treatment without HS nebulization (see Table 1).…”

Section: Model Parameters and Data Sourcesmentioning

confidence: 99%

The cost ‑effectiveness of hypertonic saline inhalations for infant bronchiolitis.

Rodriguez

2020

Preprint

Background Pharmacological treatment for bronchiolitis is primarily supportive because bronchodilators, steroids, and antibiotics, show little benefit. Clinical studies have suggested that nebulized 3% hypertonic solution is useful for infants with bronchiolitis. This study aims to evaluate the cost-effectiveness of the HS inhalations in infant bronchiolitis in a tropical country Methods Decision tree analysis was used to calculate the expected costs and QALYs. All cost and use of resources were collected directly from medical invoices of 193 patient hospitalized with diagnosis of bronchiolitis in tertiary centers, of Rionegro, Colombia. The utility values applied to QALYs calculations were collected from the literature. The economic analysis was carried out from a societal perspective.Results The model showed that nebulized 3% hypertonic solution, was associated with lower total cost than controls (US $200vs US $240 average cost per patient), and higher QALYs ( 0.92 vs 0.91 average per patient); showing dominance. A position of dominance negates the need to calculate an incremental cost-effectiveness ratio.Conclusion The nebulized 3% hypertonic solution was cost-effective in the inpatient treatment of infant bronchiolitis. Our study provides evidence that should be used by decision-makers to improve clinical practice guidelines and should be replicated to validate their results in other tropical countries.

“…The computerized search yield 1021 citations and a total of 75 studies were examined. Finally, the information was extracted for the construction of the economic model of 10 studies that included patients less than 18 years of age, with bronchiolitis, and with use of HS (7,(13)(14)(15)(16)(17)(18)(19). Information regarding the effect of HS was extracted from a recent meta-analysis (11,16) which compared HS nebulization versus normal saline inhalations or standard treatment without HS nebulization (see Table 1).…”

Section: Model Parameters and Data Sourcesmentioning

confidence: 99%

The Cost ‑effectiveness of Hypertonic Saline Inhalations for Infant Bronchiolitis

Rodriguez

2020

Preprint

Background Pharmacological treatment for bronchiolitis is primarily supportive because bronchodilators, steroids, and antibiotics, show little benefit. Clinical studies have suggested that nebulized 3% hypertonic solution is useful for infants with bronchiolitis. This study aims to evaluate the cost-effectiveness of the HS inhalations in infant bronchiolitis in a tropical country Methods Decision tree analysis was used to calculate the expected costs and QALYs. All cost and use of resources were collected directly from medical invoices of 193 patient hospitalized with diagnosis of bronchiolitis in tertiary centers, of Rionegro, Colombia. The utility values applied to QALYs calculations were collected from the literature. The economic analysis was carried out from a societal perspective. Results The model showed that nebulized 3% hypertonic solution, was associated with lower total cost than controls (US $200vs US $240 average cost per patient), and higher QALYs ( 0.92 vs 0.91 average per patient); showing dominance. A position of dominance negates the need to calculate an incremental cost-effectiveness ratio. Conclusion The nebulized 3% hypertonic solution was cost-effective in the inpatient treatment of infant bronchiolitis. Our study provides evidence that should be used by decision-makers to improve clinical practice guidelines and should be replicated to validate their results in other tropical countries.