Characteristics and Risk Factors for Fatality in Patients with Dengue Hemorrhagic Fever, Taiwan, 2014

Wei, Hsin-Yi; Shu, Pei-Yun; Hung, Min-Nan

doi:10.4269/ajtmh.15-0905

Cited by 21 publications

(17 citation statements)

References 33 publications

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“…Like other studies [32,33], the results of this study demonstrate that fatalities are most common in older individuals and in those with underlying comorbidities. Fatalities occurred mostly during hospitalization and were due to septic shock or respiratory failure.…”

Section: Discussionsupporting

confidence: 78%

An observational prospective cohort study of the epidemiology of hospitalized patients with acute febrile illness in Indonesia

Gasem

Kosasih²,

Tjitra

et al. 2020

PLoS Negl Trop Dis

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BackgroundThe epidemiology of acute febrile illness, a common cause of hospitalization in Indonesia, has not been systematically studied. Methodology/Principal findingsThis prospective observational study enrolled febrile patients (temperature �38˚C) aged �1 year from July 2013 until June 2016 at eight government referral teaching hospitals in seven provincial capitals in Indonesia. Patients were managed according to the hospital standardof-care (SOC), and blood samples were drawn for molecular and serological assays. Clinical data, laboratory results, and specimens for additional tests were collected at enrollment, days 14-28, and at three months. Regular follow-up visits were then scheduled for every three months either until symptoms resolved or until one year. In total, this study included 1,486 adult and pediatric patients presenting with multi-organ (768, 51.7%), gastrointestinal (497, 33.0%), respiratory (114, 7.7%), constitutional (62, 4.2%), skin and soft-tissue (24, 1.6%), central nervous system (17, 1.1%), or genitourinary (4, 0.3%) manifestations. Microbiological diagnoses were found in 1,003/1,486 (67.5%) participants, of which 351/1,003 (35.0%) were not diagnosed during hospitalization using SOC diagnostic tests. Missed diagnoses included all cases caused by Rickettsia spp., chikungunya, influenza, and Seoul virus. The most common etiologic agents identified were dengue virus (467, 46.6%),

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Section: Discussionsupporting

confidence: 78%

An observational prospective cohort study of the epidemiology of hospitalized patients with acute febrile illness in Indonesia

Gasem

Kosasih²,

Tjitra

et al. 2020

PLoS Negl Trop Dis

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“…Based on the 2015 survey, the DENV seroprevalence rate in Sanmin and Nanzih districts increased from 2.1% (30–39 y/o), to 17.1% (60–69 y/o) and 50% (70–79 y/o) ( Fig 4A ). The sharp increase in DENV seroprevalence in the 70–79 y/o group paralleled a drastic increase in the proportion of severe dengue among total dengue cases in that age group, suggesting that in addition to age and other risk factors, significant numbers of monotypically immune individuals in that age group may contribute to the observed severe dengue diseases among the elderly in Taiwan [ 14 , 36 – 38 ]. In agreement with this, analysis of indigenous dengue cases from 2002 to 2007 revealed that the majority of DHF cases (84% of total DHF cases or DHF cases ≥60 y/o) were secondary DENV infections, whereas the majority of DF cases were primary DENV infections except in 2002 [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of dengue virus in two districts of Kaohsiung City after the largest dengue outbreak in Taiwan since World War II

et al. 2018

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Dengue virus (DENV) is the leading cause of arboviral diseases in humans worldwide. In this study, we investigated the seroprevalence of DENV infection in two districts of Kaohsiung City, a metropolis in southern Taiwan, where major dengue outbreaks have occurred in the past three decades. We enrolled 1,088 participants from the Sanmin and Nanzih districts after the dengue outbreak of 2015, the largest in Taiwan since World War II, and found an overall DENV seroprevalence of 12.4% (95% confidence interval: 10.5–13.4%) based on the InBios DENV IgG ELISA kit. The ratios of clinically inapparent to symptomatic infections were 2.86 and 4.76 in Sanmin and Nanzih districts, respectively. Consistent with higher case numbers during recent outbreaks, the DENV seroprevalence was higher in Sanmin district (16.4%) than in Nanzih district (6.9%), suggesting district differences in seroprevalence and highlighting the importance of screening the DENV immune status of each individual before using the currently available DENV vaccine, Dengvaxia. In the two districts, the seroprevalence rates increased from 2.1% (in the 30–39-year age group) to 17.1% (60–69) and 50% (70–79). The pattern of a sharp and significant increase in seroprevalence in the 70–79-year age group correlated with a dramatic increase in the proportion of clinically severe DENV infections among total dengue cases in that age group. This differed from observations in the Americas and Southeast Asia and suggested that a large proportion of monotypically immune individuals together with other risk factors may contribute to clinically severe dengue among the elderly in Taiwan.

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“…The serotype of DENV infection (during acute phase) was determined by real-time polymerase chain reaction (RT-PCR) detection of viral genome using serotype specific primers. The primary and secondary DENV infections were determined by anti-DENV IgG level and anti-DENV IgM/IgG ratio according to the published method [ 30 ]. Written informed consent was obtained from each of the research participants.…”

Section: Methodsmentioning

confidence: 99%

Dengue immune sera enhance Zika virus infection in human peripheral blood monocytes through Fc gamma receptors

Zhao

Zhang

et al. 2018

PLoS ONE

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Antibody dependent enhancement (ADE) has most often been associated with dengue virus (DENV). Studies using leukemia cell lines suggest that DENV specific antibodies can enhance Zika virus (ZIKV) infectivity, and vice versa. To examine the mechanisms of ADE of ZIKV infection in primary human cells, we assessed 40 serum samples obtained from convalescent DENV-1 or DENV-3 infected subjects. All sera tested exhibited high binding potency, while modest or none neutralization activities against ZIKV. Primary CD14+ monocytes, rather than B and T cells in peripheral blood mononuclear cells (PBMCs), were found to be the mediators of the enhancement of ZIKV infectivity by DENV immune sera. Monocyte-derived immature dendritic cells (DCs), but not mature DCs were highly permissive to ZIKV infection, whereas neither immature nor mature DCs could mediate enhanced ZIKV infection in the presence of DENV immune sera. In addition, antibody blocking of either FcγRI (CD64), or FcγRII (CD32), or FcγRIII (CD16) resulted in diminished ADE of ZIKV infection. Our findings provide an improved understanding of the pathogenesis of ZIKV infection, and inform rational vaccine design.

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Characteristics and Risk Factors for Fatality in Patients with Dengue Hemorrhagic Fever, Taiwan, 2014

Cited by 21 publications

References 33 publications

An observational prospective cohort study of the epidemiology of hospitalized patients with acute febrile illness in Indonesia

An observational prospective cohort study of the epidemiology of hospitalized patients with acute febrile illness in Indonesia

Seroprevalence of dengue virus in two districts of Kaohsiung City after the largest dengue outbreak in Taiwan since World War II

Dengue immune sera enhance Zika virus infection in human peripheral blood monocytes through Fc gamma receptors

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