Characteristics of patients infected with common Neisseria gonorrhoeae NG-MAST sequence type strains presenting at the Edinburgh genitourinary medicine clinic

Abstract

There was a trend towards significance when comparing the risks of carriage/contact with HIV between different sequence type clusters. Further research is therefore warranted to determine if NG-MAST data can be used to help identify high-risk sexual networks.

Molecular epidemiology of gonorrhoea in Wales (UK)

“…As shown previously5 16 there was high concordance (83%) between NG-MAST STs and named sexual contacts demonstrating again the application of NG-MAST as a confirmatory tool with contact tracing. However, the use of NG-MAST alone in social network analysis does have limitations as STI networks are not closed and inference on which network or cluster an individual belongs to should be taken with great care.…”

“…A study of the gonococcal population in patients attending an STI clinic in Edinburgh also showed STs 4, 64, 210 and 225 were MSM-associated 16. STs 147, 225 and 359 have been reported in MSM in other European countries,17–19 although the Scottish study and another conducted in Sweden suggested that ST 147 can be observed in a significant proportion of heterosexual patients also 16 20. To our knowledge, the association between MSM and STs 1634, 960 and 597 has not been reported previously.…”

“…STs 2, 8, 51 and 25 in London4 6 15 and ST 249 in Edinburgh, Scotland,16 have been noted previously to predominate in heterosexual patients, while the associations between STs 147, 225, 64, 210 and 359 and MSM were also reported in patients in London 4 6 15. A study of the gonococcal population in patients attending an STI clinic in Edinburgh also showed STs 4, 64, 210 and 225 were MSM-associated 16. STs 147, 225 and 359 have been reported in MSM in other European countries,17–19 although the Scottish study and another conducted in Sweden suggested that ST 147 can be observed in a significant proportion of heterosexual patients also 16 20.…”

Neisseria gonorrhoeae molecular typing for understanding sexual networks and antimicrobial resistance transmission: A systematic review

“…Over one third of studies used isolates collected in the UK (37%; 18/49), 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 from consecutive patients during the study time period (35%; 17/49), 11 , 14 , 15 , 16 , 17 , 21 , 22 , 24 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 or limited inclusion of isolates to those known to be resistant to a specific antimicrobial (35%; 17/49). 9 , 10 , 13 , 18 , 19 , 20 , 23 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 The number of isolates sampled ranged from six to 3326, with studies covering a time period of less than six months to nine years (Supplementary material).…”

Modern aspects of epidemiological surveillance of gonococcal infection spread

“…К настоящему времени имеются сообщения: -о возможности использования данных NG-MAST для изучения штаммов N. gonorrhoeae, циркулирующих в определенном географическом регионе [96]; -об ассоциациях отдельных кластеров штам-мов N. gonorrhoeae, установленных методом NG-MAST, с эпидемиологически значимыми группами пациентов, в частности, с МСМ [97]; -о возможностях использования метода NG-MAST и других методов ДНК-типирования для изуче-ния закономерностей распространения гонококковой инфекции среди половых партнеров [98][99][100][101][102];…”