Characteristics of patients with spontaneous resolution of sesame allergy

Mahlab-Guri, Keren; Guri, Alex; Kadar, L.; Asher, Ilan; Sthoeger, Zev; Elbirt, Daniel; Rosenberg-Bezalel, Shira

doi:10.1016/j.anai.2021.10.031

Cited by 12 publications

(11 citation statements)

References 27 publications

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“…Conversely, parents' atopic diseases did not correlate with sesame allergy in infants in the HealthNuts study 19 . Other than having tree nuts allergies, no other atopic diseases were correlated with the persistence of sesame allergy in Mahlab‐Guri's study 27 …”

Section: The Prevalence and Natural History Of Sesame Allergymentioning

confidence: 83%

“…The first appearance of suspected sesame allergy usually occurred in childhood, at a mean age of 11.04 ± 10.2 months. 27 Males (66.8%) were more affected than females, and most of the reactions were mild, involving only one organ (skin, conjunctiva, or upper respiratory tract). Forty-one percent had concomitant food allergies, mostly to eggs (14.2%), peanut (12.6%), or tree nuts (10%), and 46.3% had other allergic diseases such as atopic dermatitis, asthma, or allergic rhinitis.…”

Section: The Natural History Of Sesame Allergymentioning

confidence: 98%

“…Sesame allergy was confirmed by SPT or OFC in 190 Israeli children, who were followed for almost 4 years. The first appearance of suspected sesame allergy usually occurred in childhood, at a mean age of 11.04 ± 10.2 months 27 . Males (66.8%) were more affected than females, and most of the reactions were mild, involving only one organ (skin, conjunctiva, or upper respiratory tract).…”

Section: The Prevalence and Natural History Of Sesame Allergymentioning

confidence: 99%

“…19 Other than having tree nuts allergies, no other atopic diseases were correlated with the persistence of sesame allergy in Mahlab-Guri's study. 27…”

Section: Sesame Allergy Among Adults Has Not Been Studied Extensivelymentioning

confidence: 99%

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Sesame allergy in children: New insights into diagnosis and management

Saf,

Borres,

Södergren

2023

Pediatric Allergy Immunology

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Sesame is a potentially potent allergen that can trigger skin, gastrointestinal, and respiratory tract symptoms, and anaphylaxis. Only 20% to 30% of sesame‐allergic children develop tolerance. The prevalence of sesame allergy depends on local diets and ranges from 0.1% to 0.9%. A high risk of accidental exposure to sesame has resulted in mandatory food labeling in many countries. More than half of patients with sesame allergy are also allergic to peanut/tree nuts. Serum‐specific IgE testing with a quantitative Ses i 1 component can be performed safely and has higher clinical specificity and better positive predictive value for oral food challenge (OFC) than whole sesame extract or skin prick testing (SPT). Compared with SPT or OFC, in vitro Ses i 1 testing requires no special techniques and carries no risk of reactions. Diagnosis of suspected sesame allergy begins with a thorough history and physical examination. A positive sesame extract test (≥0.1 kUA/L) should prompt further testing. In patients with a high probability of reacting, results of component testing may facilitate a decision about performing an OFC. In a Japanese study of OFC and Ses i 1, there was a 5% probability of a positive OFC with Ses i 1 sIgE levels <0.13 kUA/L, and a 50% probability of a positive OFC with levels >32.0 kUA/L. Most patients could safely consume sesame if sIgE levels were <0.13 kUA/L. Ses i 1 testing can be used to guide appropriate management (avoidance, emergency medication, and oral immunotherapy).

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Section: The Prevalence and Natural History Of Sesame Allergymentioning

confidence: 83%

Section: The Natural History Of Sesame Allergymentioning

confidence: 98%

Section: The Prevalence and Natural History Of Sesame Allergymentioning

confidence: 99%

“…19 Other than having tree nuts allergies, no other atopic diseases were correlated with the persistence of sesame allergy in Mahlab-Guri's study. 27…”

Section: Sesame Allergy Among Adults Has Not Been Studied Extensivelymentioning

confidence: 99%

See 2 more Smart Citations

Sesame allergy in children: New insights into diagnosis and management

Saf,

Borres,

Södergren

2023

Pediatric Allergy Immunology

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“…Sesame is an emerging culprit for food allergy in childhood, with estimated prevalence in children of 0.2–0.8% [ 25 , 62 , 63 ]. Sesame allergy studies show slightly higher rates of resolution compared to peanut, tree nuts, fish, and shellfish, with most studies reporting an estimated 30% of children acquiring tolerance by 4–5 years [ 1 , 62 , 64 ].…”

Section: Infancy and Early Childhoodmentioning

confidence: 99%

The Natural History and Risk Factors for the Development of Food Allergies in Children and Adults

Lee,

Trogen,

Brady

et al. 2024

Curr Allergy Asthma Rep

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Purpose of Review This narrative review explores food allergy prevalence and natural history stratified by life stages, especially in context of evolving knowledge over the last few decades. Recent Findings The prevalence of food allergy remains highest in early childhood with common food triggers being cow’s milk, soy, hen’s egg, wheat, peanut, tree nuts, sesame, fish, and shellfish. This correlates with certain risk factors especially pertinent in the postnatal period which appear to predispose an individual to developing a food allergy. Some allergies (such as milk and egg) were previously thought to be easily outgrown in early life; however, recent studies suggest increasing rates of persistence of these allergies into young adulthood; the reason behind this is unknown. Despite this, there is also evidence demonstrating that food allergies can be outgrown in adolescents and adults. Summary An understanding of the paradigm shifts in the natural history of food allergy allows clinicians to provide updated, age-appropriate, and tailored advice for patients on the management and prognosis of food allergy.

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Open sesame: Shedding light on an emerging global allergen

Weiss

Smith

2023

Annals of Allergy, Asthma & Immunology

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Characteristics of patients with spontaneous resolution of sesame allergy

Cited by 12 publications

References 27 publications

Sesame allergy in children: New insights into diagnosis and management

Sesame allergy in children: New insights into diagnosis and management

The Natural History and Risk Factors for the Development of Food Allergies in Children and Adults

Open sesame: Shedding light on an emerging global allergen

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