Characteristics of structural and functional organization of the brain

Damulin, I V

doi:10.17116/jnevro2016116111163-168

Cited by 1 publication

(1 citation statement)

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“…A phenotypic modular classification analysis found that structural and functional modules exist in the brain [23]. For example, Chen et al [24] discovered six modules based on the correlation of cortical thickness; these modules are related to closely overlapping known functional domains, which indicates that functional specialization and integration coexist in the human brain [25]. Thus, analysis of the relationship between subcortical structure modules and genetic factors may reflect the underlying biological mechanism of neurodegenerative disorders such as AD.…”

Section: Introductionmentioning

confidence: 99%

Quantitative Trait Module-Based Genetic Analysis of Alzheimer’s Disease

Yuan

Xie

et al. 2019

IJMS

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The pathological features of Alzheimer’s Disease (AD) first appear in the medial temporal lobe and then in other brain structures with the development of the disease. In this work, we investigated the association between genetic loci and subcortical structure volumes of AD on 393 samples in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort. Brain subcortical structures were clustered into modules using Pearson’s correlation coefficient of volumes across all samples. Module volumes were used as quantitative traits to identify not only the main effect loci but also the interactive effect loci for each module. Thirty-five subcortical structures were clustered into five modules, each corresponding to a particular brain structure/area, including the limbic system (module I), the corpus callosum (module II), thalamus–cerebellum–brainstem–pallidum (module III), the basal ganglia neostriatum (module IV), and the ventricular system (module V). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment results indicate that the gene annotations of the five modules were distinct, with few overlaps between different modules. We identified several main effect loci and interactive effect loci for each module. All these loci are related to the function of module structures and basic biological processes such as material transport and signal transduction.

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Section: Introductionmentioning

confidence: 99%