Characteristics, treatment patterns, and outcomes in patients with high-risk locally advanced cervical cancer

Coutinho, Francesca; Gokhale, Mugdha; Doran, Charlotte; Monberg, Matthew; Yamada, Karin; Chen, Lei

doi:10.1016/j.ctarc.2024.100800

Cancer Treatment and Research Communications

2024

DOI: 10.1016/j.ctarc.2024.100800

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Characteristics, treatment patterns, and outcomes in patients with high-risk locally advanced cervical cancer

Francesca Coutinho,

Mugdha Gokhale,

Charlotte Doran

et al.

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2024

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Cited by 2 publications

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Real world data on cervical cancer treatment patterns, healthcare access and resource utilization in the Brazilian public healthcare system

Campuzano,

Borba,

de Mendonça Batista

et al. 2024

PLoS ONE

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The aim of the study is to evaluate the treatment patterns, time to start treatment, and healthcare resources utilization (HCRU) of cervical cancer (CC) patients within the Brazilian public health system (SUS). This is an observational retrospective study using SUS administrative database (DATASUS). Data from January-2014 to December-2020 was gathered from patients with the ICD-10 C53 codes. From 2014 to 2020, 206,861 women were included, among whom 90,073 (43.5%) had stage information. Of staged patients, 60.7% (54,719) had advanced disease (stages III and IV) and the most performed treatments were chemoradiotherapy (CRT) (41.6%), surgery + CRT (19.1%), radiotherapy (RT) only (16.8%) and chemotherapy (CT) only (13.3%). The proportion of patients submitted to CT in advanced stages was higher than in non-advanced stages (I and II), in contrast to RT, which was more frequent in stage I than stage IV. Median time to initiate treatment surpassed two months in approximately 30% of the cases, regardless of stage. Conization was the most performed surgical procedure. The hospitalization rate per patient per month for stage IV was twice as high as stage I (0.05 [95%CI 0.05–0.05] and 0.11 [0.11–0.11], respectively). The same trend was observed for outpatient visits (0.54 [95%CI 0.53–0.55] and 0.96 [0.93–0.98], respectively). This study demonstrated a high proportion of advanced CC at diagnosis in Brazil. The treatment pattern showed that chemoradiotherapy was the most frequent regimen overall and the use of chemotherapy and HCRU increased with staging. These results could provide information to improve public policies towards access to prevention, diagnosis, and treatment of CC in Brazil.

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Real world data on cervical cancer treatment patterns, healthcare access and resource utilization in the Brazilian public healthcare system

Campuzano,

Borba,

de Mendonça Batista

et al. 2024

PLoS ONE

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A comprehensive review of m ⁶ A research in cervical cancer

Hu,

Wang,

2024

Epigenomics

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Cervical cancer (CC) remains one of the most common malignancies among women worldwide, posing a serious threat to women's health. N6-methyladenosine (m6A) modification, as the most abundant type of RNA methylation modification, and has been found to play a crucial role in various cancers. Current research suggests a close association between RNA m6A modification and the occurrence and progression of CC, encompassing disruptions in m6A levels and its regulatory machinery. This review summarizes the current status of m6A modification research in CC, explores the mechanisms underlying m6A levels and regulators (methyltransferases, demethylases, reader proteins) in CC and examines the application of small-molecule inhibitors of m6A regulators in disease treatment. The findings provide new insights into the future treatment of CC.

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Characteristics, treatment patterns, and outcomes in patients with high-risk locally advanced cervical cancer

Cited by 2 publications

References 35 publications

Real world data on cervical cancer treatment patterns, healthcare access and resource utilization in the Brazilian public healthcare system

Real world data on cervical cancer treatment patterns, healthcare access and resource utilization in the Brazilian public healthcare system

A comprehensive review of m ⁶ A research in cervical cancer

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Characteristics, treatment patterns, and outcomes in patients with high-risk locally advanced cervical cancer

Cited by 2 publications

References 35 publications

Real world data on cervical cancer treatment patterns, healthcare access and resource utilization in the Brazilian public healthcare system

Real world data on cervical cancer treatment patterns, healthcare access and resource utilization in the Brazilian public healthcare system

A comprehensive review of m 6 A research in cervical cancer

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A comprehensive review of m ⁶ A research in cervical cancer