Characterization and antibiotic resistance pattern of diffusely adherent Escherichia coli (DAEC), isolated from paediatric diarrhoea in Shiraz, southern Iran

Javadi, Kasra; Mohebi, Samane; Motamedifar, Mohammad; Hadi, Nahal

doi:10.1016/j.nmni.2020.100780

Cited by 10 publications

(16 citation statements)

References 39 publications

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“…An important step in DAEC infection is the specific colonization of the small bowel mediated by the Afa/Dr family of adhesins, including the two main classes of adhesins presented on the surface of the pathogen: fimbrial adhesins (including linear polymers) and afimbrial adhesins (homotrimers or single proteins) [ 111 , 112 , 113 ]. Afa/Dr adhesins include Dr, DrII, AfaE/I–III, AfaE-V, NFA-I, and F1845 adhesins.…”

Section: Diffusely Adherent Escherichia Coli (Daec)mentioning

confidence: 99%

Virulence Factors of Enteric Pathogenic Escherichia coli: A Review

Pakbin

Brück²,

Rossen

2021

IJMS

153

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Escherichia coli are remarkably versatile microorganisms and important members of the normal intestinal microbiota of humans and animals. This harmless commensal organism can acquire a mixture of comprehensive mobile genetic elements that contain genes encoding virulence factors, becoming an emerging human pathogen capable of causing a broad spectrum of intestinal and extraintestinal diseases. Nine definite enteric E. coli pathotypes have been well characterized, causing diseases ranging from various gastrointestinal disorders to urinary tract infections. These pathotypes employ many virulence factors and effectors subverting the functions of host cells to mediate their virulence and pathogenesis. This review summarizes new developments in our understanding of diverse virulence factors associated with encoding genes used by different pathotypes of enteric pathogenic E. coli to cause intestinal and extraintestinal diseases in humans.

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Section: Diffusely Adherent Escherichia Coli (Daec)mentioning

confidence: 99%

Virulence Factors of Enteric Pathogenic Escherichia coli: A Review

Pakbin

Brück²,

Rossen

2021

IJMS

153

View full text Add to dashboard Cite

show abstract

“…An important step in DAEC infection is specific colonization of the small bowel mediated by the Afa/Dr family of adhesins, including the two main classes of adhesins presented on the surface of the pathogen: fimbrial adhesins (including linear polymers) and afimbrial adhesins (homotrimers or single proteins) [111][112][113]. Afa/Dr adhesins include Dr, DrII, AfaE/I-III, AfaE-V, NFA-I and F1845 adhesins.…”

Section: Enteroaggregative Escherichia Coli (Eaec)mentioning

confidence: 99%

“…Interaction between Afa/Dr adhesins, flagella and DAF receptors mediates IL-8 secretion and promote the transmigration of polymorphonuclear neutrophils (PMNs). This causes DAF upregulation on the epithelial cell surface, providing more adhesion receptors [107,112]. Interaction between PMNs and Afa/Dr adhesins accelerates PMN associated apoptosis and decreases the rate of phagocytosis mediated by PMNs.…”

Section: Enteroaggregative Escherichia Coli (Eaec)mentioning

confidence: 99%

“…Interaction between PMNs and Afa/Dr adhesins accelerates PMN associated apoptosis and decreases the rate of phagocytosis mediated by PMNs. Across the epithelial cells, DAEC strains also induce the expression of MICA which is potentially responsible for mediating inflammatory bowel disease (IBD) [112,116].…”

Section: Enteroaggregative Escherichia Coli (Eaec)mentioning

confidence: 99%

“…Although the pathogenesis of DAEC strains is mainly mediated through Afa/Dr adhesins, some SPATE toxins are secreted by this pathotype [112]. Afa/Dr DAEC strains release two main classes of SPATE toxins: class I with cytotoxic activity against epithelial cells, including a secreted autotransporter toxin, a plasmid-encoded toxin, an extracellular serine protease and sigA toxins, encoded by sat, pet, EspP and sigA genes, respectively; class II which are not cytotoxic and consisting of a protein involved in intestinal colonization encoded by the pic gene [12,88,115].…”

Section: Enteroaggregative Escherichia Coli (Eaec)mentioning

confidence: 99%

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Virulence factors of Enteric Pathogenic Escherichia coli: A Review

Pakbin¹,

Brück²,

Rossen³

2021

Preprint

View full text Add to dashboard Cite

Escherichia coli are remarkably versatile microorganisms and important members of the normal intestinal microbiota of humans and animals. This harmless commensal organism can acquire a mixture of comprehensive mobile genetic elements that contain genes encoding viru-lence factors, becoming an emerging human pathogen capable of causing a broad spectrum of intestinal and extraintestinal diseases. Nine definite enteric E. coli pathotypes have been well characterized, causing diseases ranging from various gastrointestinal disorders to urinary tract infections. These pathotypes employ many virulence factors and effectors subverting the func-tions of host cells to mediate its virulence and pathogenesis. This review summarizes new de-velopments in our understanding of diverse virulence factors associated encoding genes used by different pathotypes of enteric pathogenic E. coli to cause intestinal and extraintestinal diseases in humans.

show abstract