Characterization and carboplatin loaded chitosan nanoparticles for the chemotherapy against breast cancer in vitro studies

Khan, Mateen A.; Zafaryab, Md.; Mehdi, Syed Hassan; Quadri, Javed Ahsan; Rizvi, Abbas

doi:10.1016/j.ijbiomac.2016.12.090

Cited by 72 publications

(31 citation statements)

References 39 publications

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“…As a novel drug control release delivery carrier, the preparation and application of chitosan-based nanoparticles (CS NPs) display a great promising potential in the treatment and diagnosis of cancer treatment [19,20]. In view of their shape and size, CS NPs can be easily aggregated and accumulated inside tumour tissues for a long time.…”

Section: Introductionmentioning

confidence: 99%

Chitosan nanoparticles induced the antitumor effect in hepatocellular carcinoma cells by regulating ROS-mediated mitochondrial damage and endoplasmic reticulum stress

Jiang

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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2019) Chitosan nanoparticles induced the antitumor effect in hepatocellular carcinoma cells by regulating ROSmediated mitochondrial damage and endoplasmic reticulum stress, Artificial Cells, Nanomedicine, and Biotechnology, 47:1, 747-756, ABSTRACTIn recent years, numerous studies have confirmed the role of chitosan nanoparticles (CS NPs) as a promising drug delivery carrier for improving the efficiency of anticancer drug in the treatment of cancer. However, the possible biological effects of CS NPs on tumour cells and underlying mechanisms are still unclear. Recently, reactive oxygen species (ROS)-mediated cell apoptosis has been implicated in the regulation of cell death. In this study, we found that CS NPs induced the massive generation of ROS and resulted in apoptosis of hepatocellular carcinoma cells (SMMC-7721) through activating the mitochondrial pathway and endoplasmic reticulum stress. These results suggest an important role of ROS in CS NPs-induced cancer cell death. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Chitosan nanoparticles induced the antitumor effect in hepatocellular carcinoma cells by regulating ROS-mediated mitochondrial damage and endoplasmic reticulum stress

Jiang

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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“…The encapsulation efficiency was 58.43, and load efficiency was 13.27 for carboplatin. The toxicity study by MTT assay in the MCF-7 cell line showed that chitosan nanoparticles did not show significant toxicity at concentrations of 200 g/mL at 24, 48, and 72 h [31].…”

Section: Chitosan Nanoparticlementioning

confidence: 96%

A Critical Comparison Study on the pH-Sensitive Nanocomposites Based on Graphene-Grafted Chitosan for Cancer Theragnosis

Gooneh-Farahani

Naghib

Naimi‐Jamal

2019

Multidiscip Cancer Investig

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Drug delivery is one of the major issues in the world of science, which receives a large part of the research in various fields. The ultimate goal of drug delivery is to help the patient with developing advanced drug delivery systems. These systems revolutionize the treatment of many diseases including cancer. Effective drug carriers can significantly reduce the undesirable side effects of anticancer drugs through the drug controlled release and using the selective drug to cancerous tissue. The natural biocompatible and biodegradable polymer of chitosan is widely investigated in drug delivery systems, especially as the carrier for anticancer drugs. An important aspect for the application of chitosan in drug delivery for cancer treatment is its pH sensitivity. Graphene attracted much attention in various fields as a shining star in the science of materials. In recent years, the use of graphene in the diagnosis and treatment of cancer is also investigated. Therefore, chitosan-graphene nanocomposite can be introduced as a pH-sensitive carrier for cancer theragnosis. In the current study, the application of chitosan and graphene in the treatment of cancer addressed in previous years was discussed.

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“…When analysed in vitro, the NPs showed improved cytotoxicity effects against MCF-7 cell line. The group concluded that the CPT chitosan NPs could be used as a potential candidate for cancer treatment [43]. In a more recent study, pH-responsive chitosan-grafted-poly(methacrylic acid)/graphene oxide (CS-g-PMAA/GO) NPs were formulated as a potential chemotherapeutic delivery platform.…”

Section: Chitosanmentioning

confidence: 99%

Nanotechnology-Based Biopolymeric Oral Delivery Platforms for Advanced Cancer Treatment

Chivere

Kondiah

Choonara

et al. 2020

Cancers

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Routes of drug administration and their corresponding physiochemical characteristics play major roles in drug therapeutic efficiency and biological effects. Each route of delivery has favourable aspects and limitations. The oral route of delivery is the most convenient, widely accepted and safe route. However, the oral route of chemotherapeutics to date have displayed high gastric degradation, low aqueous solubility, poor formulation stability and minimum intestinal absorption. Thus, mainstream anti-cancer drugs in current formulations are not suitable as oral chemotherapeutic formulations. The use of biopolymers such as chitosan, gelatin, hyaluronic acid and polyglutamic acid, for the synthesis of oral delivery platforms, have potential to help overcome problems associated with oral delivery of chemotherapeutics. Biopolymers have favourable stimuli-responsive properties, and thus can be used to improve oral bioavailability of anti-cancer drugs. These biopolymeric formulations can protect gastric-sensitive drugs from pH degradation, target specific binding sites for targeted absorption and consequently control drug release. In this review, the use of various biopolymers as oral drug delivery systems for chemotherapeutics will be discussed.

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Characterization and carboplatin loaded chitosan nanoparticles for the chemotherapy against breast cancer in vitro studies

Cited by 72 publications

References 39 publications

Chitosan nanoparticles induced the antitumor effect in hepatocellular carcinoma cells by regulating ROS-mediated mitochondrial damage and endoplasmic reticulum stress

Chitosan nanoparticles induced the antitumor effect in hepatocellular carcinoma cells by regulating ROS-mediated mitochondrial damage and endoplasmic reticulum stress

A Critical Comparison Study on the pH-Sensitive Nanocomposites Based on Graphene-Grafted Chitosan for Cancer Theragnosis

Nanotechnology-Based Biopolymeric Oral Delivery Platforms for Advanced Cancer Treatment

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