Characterization and comparison of deferasirox fast disintegrating tablets prepared by direct compression and lyophilization methods

Akdag, Yagmur; Gülsün, Tuğba; Izat, Nihan; Çetin, Meltem; Öner, Levent; Şahin, Selma

doi:10.1016/j.jddst.2020.101760

Cited by 13 publications

(8 citation statements)

References 16 publications

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“…The angle of repose value of PGTBIS (29:53 ± 0:1 °) was higher than that of the Starch 1500® (26:59 ± 0:4 °) (p < 0:05) indicating that it might have lower flowability. However, both the PGTBIS and Starch 1500® were within the range of excellent flowability index (25-30 °) in USP/NF [36]. The Carr index of PGTBIS Bulk density (g/ml) 0:62 ± 0:00 0:45 ± 0:00 0:61 ± 0:01…”

Section: Validation Of the Optimization And Comparativementioning

confidence: 92%

“…(16:85 ± 0:43%) was comparable to that of the Starch 1500® (16:61 ± 0:18%) (p > 0:05) but noticeably lower than that of NTBIS (23:1 ± 0:70%) (p < 0:05). These values of Carr's index gave a good promise regarding the compressibility and hence the tabletability of the powder [36]. The reason for low Carr's index could be low interparticular interaction which favors compressibility.…”

Section: Validation Of the Optimization And Comparativementioning

confidence: 96%

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Optimization of Pregelatinized Taro Boloso‐I Starch as a Direct Compression Tablet Excipient

Balla

Joseph

Belete

2023

BioMed Research International

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Background. Tablets are still the most preferred means of drug delivery. The search for new and improved direct compression tablet excipients is an area of research focus. This is because the direct compression method overcomes the drawbacks of granulation methods of tablet production. It exempts several treatment steps associated with the granulation methods. The requirements for the powders to be directly compressible include flowability, low friction tendency, compressibility, and fast disintegration capacity. Taro Boloso-I is a new variety of Colocasia esculenta (L. Schott) yielding 67% more than a previously reported variety (Godare) in Ethiopia. This study is aimed at enhancing the flowability while keeping the compressibility and compactibility of the pregelatinized Taro Boloso-I starch. Methods. Central composite design was used for the optimization of two factors which were the temperature and duration of pregelatinization against 4 responses. The responses were angle of repose, Hausner’s ratio, Heckel’s yield pressure, and tablet breaking force. Results and Discussions. An increase in the temperature resulted in decrease in both the angle of repose and the Hausner ratio and that of time decreased angle of repose as well. The Heckel yield pressure was observed to increase with increasing levels of both temperature and time. The pregelatinized starch prepared by heating 15% slurry of Taro Boloso-I starch at the pregelatinization temperature of 66.22°C for 20 min showed desired flow property and compressibility. Conclusions. Pregelatinized Taro Boloso-I starch could be regarded as a potential direct compression excipient in terms of flowability, compressibility, and compactibility. The PGTBIS could perform better as filler and binder in direct compression tablets than the Starch 1500® in terms of compactibility.

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Section: Validation Of the Optimization And Comparativementioning

confidence: 92%

Section: Validation Of the Optimization And Comparativementioning

confidence: 96%

Optimization of Pregelatinized Taro Boloso‐I Starch as a Direct Compression Tablet Excipient

Balla

Joseph

Belete

2023

BioMed Research International

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“…Pre-compression parameters of FDTs of OM Measurements of the repose angle, compressibility index, Hausner's ratio (Akdag et al, 2020), bulk and tapped densities (Alyoussef et al, 2017) were made to evaluate the powder blends.…”

Section: Preparation Of Fast Dissolving Tablets (Fdts) Of Ommentioning

confidence: 99%

Untitled

2022

Pak. J. Pharm. Sci.,

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This study aims to formulate Olmesartan medoxomil (OM) into oral fast-dissolving tablets (FDTs) to improve its solubility and bioavailability via two different techniques; the polymer-based surface solid dispersion (SSD) technique and the solidified surfactant (SS) technique. In the first technique, two polymers were used; polyvinylpyrrolidone (PVP K90) and Poloxamer 407 (Pluronic®F127), while in the second technique the liquid Tween 80 was solidified by adsorption onto Aeroperl®300. The pre-compression and post-compression parameters of the obtained formulations were assessed. The best formulations were subjected to a taste masking evaluation and a shortterm stability study. The results demonstrated that, in comparison to the pure drug, the proportion of drug released from each of the prepared FDTs considerably increased. Results of the stability studies showed that the chosen drug formulations remained stable throughout the storage period.

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“…4 ODT disintegrates rapidly in the mouth which aids in rapid dissolution, improves the drug absorption, and accelerates its onset of action. 5 An enhancement of the dissolution rates of water-insoluble drugs is one of the most challenging tasks of drug development because the enhanced dissolution rates can improve drug oral bioavailability. 6 The first ODT approved by the food and drug administration (FDA) in 1996 was Zydis®, which was prepared by the lyophilization method.…”

Section: Introductionmentioning

confidence: 99%

“…6 The first ODT approved by the food and drug administration (FDA) in 1996 was Zydis®, which was prepared by the lyophilization method. 5 Oral lyophilizates are defined according to European Pharmacopoeia as "solid preparations intended either to be placed in the mouth or to be dispersed or dissolved in water before administration". 7 In the lyophilization process, the solvent is removed from the frozen solution or suspension of a drug and excipients under low temperature.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Cinnarizine Oral Lyophilizates

Dhahir¹,

Alkotaji²

2021

Iraqi J. Pharm.

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Background: Orally disintegrating tablets (ODTs) have gained an increasing interest in the pharmaceutical industry for the last years. Several technologies have been sophisticated for ODTs to improve patient compliance. In the present work, an attempt has been made to formulate and evaluate cinnarizine, a drug for motion sickness, in an easy to administer, rapid disintegrated dosage form (oral lyophilizates with enhanced disintegration and dissolution profile and consequent potential improvement in bioavailability. Materials and Methods:Cinnarizine oral lyophilizates were prepared by dispersing the drug in an aqueous solution of mannitol, hydroxypropyl methyl cellulose, and glycine. Different formulations were prepared by freeze-drying (lyophilisation) technique. The effect of concentration of mannitol, hydroxypropyl methyl cellulose, and freezing time on the lyophilizates characteristics was investigated. The drug-excipient interaction was investigated as well. Results:The resulting cinnarizine oral lyophilizates showed an enhanced disintegration (27.5±3.53 sec to 56±12.73 sec) and enhanced dissolution profile (25.09% to 44.7% after two minutes). The infrared spectroscopic studies showed no drug-excipient interactions. Furthermore, increasing the concentration of mannitol, increasing the concentration of hydroxypropyl methyl cellulose and duplication of the duration of freezing time had a negative influence on the disintegration and dissolution properties of the resulting lyophilizates. Conclusion:Cinnarizine oral lyophilizates were successfully prepared and resulted in a rapid disintegration, high dissolution profile, with stable characteristics and without noticeable drugexcipient interaction.

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Characterization and comparison of deferasirox fast disintegrating tablets prepared by direct compression and lyophilization methods

Cited by 13 publications

References 16 publications

Optimization of Pregelatinized Taro Boloso‐I Starch as a Direct Compression Tablet Excipient

Optimization of Pregelatinized Taro Boloso‐I Starch as a Direct Compression Tablet Excipient

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Preparation of Cinnarizine Oral Lyophilizates

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