Characterization And Compatibility Studies Of Valsartan With Pharmaceutical Excipients

Abstract

The thermal analytical study of valsartan chemically N-(1-oxopentyl) -N- [[2'-(1H-tetrazol-5-yl) [1, 1'biphenyl] -4-yl] methyl]-L-valine, an anti-hypertensive was investigated using differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM). The DSC curves have shown a sharp endothermic event at 101.16°C. Solid state characterization was carried out by FTIR, scanning electron microscopy SEM, and XRPD demonstrating the drug physicochemical properties including crystallinity. Drug-excipient compatibility studies investigated by DSC with different excipients like Magnesium stearate, Sodium starch glycolate, Potato starch, Crospovidone, Croscarmellose, Sodium Starch Glycolate, PolyEthyleneGlycol 6000, pregelatizedstarch, talc, lactose, polyvinylpyrollidine K30, sodiumcarboxymethyl cellulose, micro crystalline cellulose. DSC spectra's has shown a possible physical interaction of the drug with magnesium stearate, polyvinylpyrollidine K30 (PVP K30), PolyEthyleneGlycol 6000 (PEG 6000) and Potato starch.