Characterization and effect of nanocomplexed fluoride solutions on the inhibition of enamel demineralization created by a multispecies cariogenic biofilm model

Vieira, Thiago Isidro; Alexandria, Adílis Kalina; Menezes, Jaqueline Correia Villaça; Amaral, Lilian; Santos, Thais M. dos; Neves, Aline de Almeida; Lopes, Ricardo Tadeu; Cabral, Lúcio Mendes; Valença, Ana Maria Gondim; Maia, Lucianne Cople

doi:10.1007/s00784-020-03261-0

Cited by 3 publications

(2 citation statements)

References 51 publications

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“…When the image is blurred and the noise is small, the working state of the gradient operator is a satisfactory continuous image f ðx, yÞ, and the position gradient ðx, yÞ can be expressed as a carrier [10]. If G x and G y are used to represent the gradient change of f ðx, yÞ along the X and Y directions, the gradient vector can be expressed as follows [11]: A transformation method based on the tangent function is as follows [12]:…”

Section: Methods and Experimentsmentioning

confidence: 99%

Binder‐Loaded Amorphous Nanometer Calcium Phosphate in Preventing Enamel Demineralization in Orthodontic Patients

Gao¹,

Dang

Zhang³

et al. 2022

Journal of Nanomaterials

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With the popularization of oral health knowledge, people have gradually realized the importance of orthodontic treatment in oral health, so the number of patients undergoing orthodontic treatment has increased significantly. To improve the effect of orthodontic treatment, this article mainly studied the application of adhesives loaded with amorphous nanocalcium phosphate in the prevention of enamel demineralization in orthodontic patients. In the experiment, we used spray-drying technology to synthesize NACP. The collected dry particles were dispersed with absolute ethanol, sonicated for 10 minutes, dropped on a 200 ordinary carbon support film, and then dried and observed with a transmission electron microscope (TEM). Prevention of enamel demineralization in orthodontic patients was by adhesive-loaded amorphous nanocalcium phosphate. In this experiment, the membrane dialysis method was used to release the drug-loaded nanoparticles. The MH-5 microhardness tester was used to randomly select 3 positions on the buccal area of the enamel surface to measure the microhardness. After measuring the microhardness of each point, take the average of the readings of the 3 positions. Before and after the experiment, the difference of the enamel surface microhardness before and after the experiment was statistically analyzed. Before the scanning electron microscope observation, to avoid contamination of the window area of the enamel surface, which will cause interference with the scanning electron microscope observation, we use acetone to remove the acid-resistant nail polish coated on the enamel surface. Clean the attachments on the surface of the teeth first, then fix, dehydrate, and dry. When the release time reaches 52 h, the cumulative release rates of Cur in pH 5.4 and pH 7.4 buffers are 85.84 and 64.68%, respectively. The results show that by adjusting the concentration of PAA, it is possible to configure a mineralized liquid that can not only use the fluidity of NACP to penetrate into the collagen fibers but also transform into HAP within a suitable time, to achieve the purpose of repairing demineralized dentin.

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Section: Methods and Experimentsmentioning

confidence: 99%

Binder‐Loaded Amorphous Nanometer Calcium Phosphate in Preventing Enamel Demineralization in Orthodontic Patients

Gao¹,

Dang

Zhang³

et al. 2022

Journal of Nanomaterials

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“…To produce the 1% TiF 4 -β-cyclodextrin nanocomplexes, 0.1974g of TiF 4 (Sigma Aldrich®, St Louis, MO, USA; purity 37 to 39% of titanium) and 2.0112 g of hydroxypropylβ-cyclodextrin (Sigma Aldrich®) were mixed in 20 mL of distilled water using a magnetic stirrer for 12 or 72 h. The mean pH value and total fluoride concentration (µg F/ mL) from the nanocomplexed solutions were 1.78±0.07 and 6123.67±343.56, respectively (18). After that, the solutions were frozen in liquid nitrogen and lyophilized.…”

Section: Preparation and Characterization Of β-Cds And Tif 4 Nanocomplexesmentioning

confidence: 99%

Cyclodextrin and TiF4 Nanocomplex on Enamel Demineralization

et al. 2020

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The aim of this study was to assess the effect of a newly developed nanocomplex formed of hydroxypropyl-b-cyclodextrin and 1% titanium tetrafluoride (TiF4) after distinct complexation periods (12/72 h) on demineralization of bovine enamel in vitro. Enamel blocks (n=60) were allocated in different groups: Mili-Q water, hydroxypropyl-b-cyclodextrin, 1% TiF4, hydroxypropyl-b-cyclodextrin + 1% TiF4 after 12 h of complexation and hydroxypropyl-b-cyclodextrin + 1% TiF4 after 72 h of complexation. The samples were evaluated by surface microhardness, cross-sectional microhardness and micro-CT. Scanning electron microscopy and energy dispersive X-ray spectrometry (SEM/EDX) were also obtained. Hydroxypropyl-b-cyclodextrin + 1% TiF4 after 12 h complexation resulted in lower percentage of surface microhardness loss compared to Mili-Q water, hydroxypropyl-b-cyclodextrin, 1% TiF4 and hydroxypropyl-b-cyclodextrin + 1% TiF4 after 72 h of complexation group, with a large effect size (from 1.307 to 2.943) and high power (84.9 to 99%). All groups resulted in similar integrated mineral loss (ΔZ) obtained by both internal microhardness and micro-CT techniques. Enamel treated with TiF4 and TiF4 + hydroxypropyl-b-cyclodextrin groups showed a TiO2 glaze-layer, while EDX evaluation identified Ti. The solution containing the inclusion complex of hydroxypropyl-b-cyclodextrin + TiF4 with 12 h of complexation period demonstrated a significant ability to reduce surface demineralization of sound enamel under an artificial cariogenic challenge.

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What is the effectiveness of titanium tetrafluoride to prevent or treat dental caries and tooth erosion? A systematic review

Chevitarese

Leite

Marañón‐Vásquez

et al. 2022

Acta Odontologica Scandinavica

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Characterization and effect of nanocomplexed fluoride solutions on the inhibition of enamel demineralization created by a multispecies cariogenic biofilm model

Cited by 3 publications

References 51 publications

Binder‐Loaded Amorphous Nanometer Calcium Phosphate in Preventing Enamel Demineralization in Orthodontic Patients

Binder‐Loaded Amorphous Nanometer Calcium Phosphate in Preventing Enamel Demineralization in Orthodontic Patients

Cyclodextrin and TiF4 Nanocomplex on Enamel Demineralization

What is the effectiveness of titanium tetrafluoride to prevent or treat dental caries and tooth erosion? A systematic review

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