Characterization and evaluation of a novel silver nanoparticles-loaded polymethyl methacrylate denture base: <i>In vitro</i> and <i>in vivo</i> animal study

Abstract

The aim of this study was to optimize the preparation method of polymethyl methacrylate (PMMA) denture base loaded with nano silver (NAg), to more effectively and safely impart sustainable antibacterial functions. NAg solution was synthetized and mixed with acrylic acid and methyl methyacrylate (MMA) monomer in order to prepare a new type of NAg solution (NS)/polymer methyl methacrylate denture base specimens (NS/PMMA). The surface morphology, mechanical strength, antimicrobial activity, anti-aging performance, cytotoxicity and biocompatibility of NS/PMMA denture base were evaluated in comparison with specimens fabricated using traditional NAg adding methods and NAg-free denture base. The aesthetic characteristics and mechanical strength of NS/ PMMA denture base met the clinical application requirements. Meanwhile, NS/PMMA denture base showed better antibacterial activity, anti-aging properties, no cytotoxicity and displayed exceptional biocompatibility. NS/PMMA denture base thus has great potential for clinical application.

Impact of Surface Changes and Microbial Adhesion on Mucosal Surface Finishing of Resin Denture Bases by Shot Blast Polishing Using Viscoelastic Media

“…Therefore, to reduce the Ra of the mucosal surface of denture bases, a treatment method that improves the surface texture of the working model is required in the future. On the other hand, methods that suppress the adhesion of microorganisms by treating the surface of denture bases have been reported [ 27 , 28 , 29 , 30 , 31 ]. A method of adhering or mixing nano-silver particles and a method of using a 2-methacryloyloxyethyl phosphorylcholine polymer or titanium dioxide for a resin base have been examined and are being applied to clinical settings.…”

Advanced materials and technologies for oral diseases

“… [ 104–109 ] TiO 2 NPs [ 110 ] SiO 2 NPs [ 111 ] ZnNPs [ 112 ] diamond NPs [ 113 ] SiC NPs Improving the thermal conductivity of PMMA. [ 114 ] Antibacterial AgNPs Antibacterial effect by coating or filling [ 115 , 116 ] Chitosan Unique antibacterial ability against Candida. [ 117 ] nGO Increasing PMMA hydrophilicity to obtain antibacterial ability.…”

“…In contrast to the mechanical properties, adding nanoparticles with the antibacterial ability and improving the hydrophobicity of PMMA are two ways to improve the antibacterial ability of PMMA. The antibacterial properties of AgNPs have been utilized to achieve specific antibacterial effects by combining AgNPs with PMMA or attaching them to the PMMA surface in the form of a coating [ 115 , 116 ]. Adding chitosan nanoparticles to PMMA due to their unique antibacterial properties against Candida can effectively reduce the colonization of oral mucosa by fungi [ 117 ].…”

Modification of Polymer Based Dentures on Biological Properties: Current Update, Status, and Findings

“…Additionally, it is a simple, inexpensive method that has a great chance of developing into an antibacterial treatment for removable partial or complete dentures. It is unquestionably an appropriate material and can be utilised for the population of elderly individuals [ 36 ].…”