Characterization and evaluation of fluoridated apatites for the development of infection-free percutaneous devices

Bennett, Brian; Beck, James P.; Papangkorn, Kongnara; Colombo, John S.; Bachus, Kent N.; Agarwal, Jayant P.; Shieh, Joshua F.; Jeyapalina, Sujee

doi:10.1016/j.msec.2019.03.025

Cited by 16 publications

(29 citation statements)

References 54 publications

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“…[28] The O-H stretching band at ≈740 cm -1 indicates the presence of hydroxyl that bonded to fluorine (F-OH); however, the exact amount of fluorine cannot be determined. [29,30] The XRD pattern of the pristine PCL scaffolds displayed two sharp peaks at 21.4°and 23.8°, respectively (Fig- ure 3b); whereas, the coated scaffolds had a pattern similar to the noncoated scaffolds in addition to a discrete peak at ≈31.8°, likely due to the CaP phase presence.…”

Section: Fabrication and Characterization Of Mew Pcl Scaffoldsmentioning

confidence: 98%

A Highly Ordered, Nanostructured Fluorinated CaP‐Coated Melt Electrowritten Scaffold for Periodontal Tissue Regeneration

Daghrery

Ferreira

Araújo

et al. 2021

Adv Healthcare Materials

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Periodontitis is a chronic inflammatory, bacteria-triggered disorder affecting nearly half of American adults. Although some level of tissue regeneration is realized, its low success in complex cases demands superior strategies to amplify regenerative capacity. Herein, highly ordered scaffolds are engineered via Melt ElectroWriting (MEW), and the effects of strand spacing, as well as the presence of a nanostructured fluorinated calcium phosphate (F/CaP) coating on the adhesion/proliferation, and osteogenic differentiation of human-derived periodontal ligament stem cells, are investigated. Upon initial cell-scaffold interaction screening aimed at defining the most suitable design, MEW poly(𝝐-caprolactone) scaffolds with 500 μm strand spacing are chosen. Following an alkali treatment, scaffolds are immersed in a pre-established solution to allow for coating formation. The presence of a nanostructured F/CaP coating leads to a marked upregulation of osteogenic genes and attenuated bacterial growth. In vivo findings confirm that the F/CaP-coated scaffolds are biocompatible and lead to periodontal regeneration when implanted in a rat mandibular periodontal fenestration defect model. In aggregate, it is considered that this work can contribute to the development of personalized scaffolds capable of enabling tissue-specific differentiation of progenitor cells, and thus guide simultaneous and coordinated regeneration of soft and hard periodontal tissues, while providing antimicrobial protection.

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Section: Fabrication and Characterization Of Mew Pcl Scaffoldsmentioning

confidence: 98%

A Highly Ordered, Nanostructured Fluorinated CaP‐Coated Melt Electrowritten Scaffold for Periodontal Tissue Regeneration

Daghrery

Ferreira

Araújo

et al. 2021

Adv Healthcare Materials

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“…5 a) [ [366] , [367] , [368] , [369] , [370] ] as has surface topography [ 371 ]. Surface coatings of an extracellular domain of E-cadherin [ 372 ], keratin isolated from human hair [ 373 ], and hydroxyapatite [ 374 , 375 ] have also been tested in vitro to reduce downgrowth. Another potential method is biofunctionalization of surfaces with elastic microfibril interface–located protein 1 (EMILIN1), an extracellular glycoprotein known to reduce keratinocyte migration and proliferation [ 376 , 377 ] Negative pressure wound therapy (NPWT) is sometimes used to help complex wound close through drawing wounds together and removing wound bed exudates [ 378 ].…”

Section: Peri-implant Junctional Epitheliummentioning

confidence: 99%

Junctional epithelium and hemidesmosomes: Tape and rivets for solving the “percutaneous device dilemma” in dental and other permanent implants

Fischer

Aparicio

2022

Bioactive Materials

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“…Fluoridation through partial and full substitution of the hydroxyl group in HA with fluorine can yield fluorohydroxyapatite (FHA) [Ca 10 (PO 4 ) 6 (OH) x F 1−x ] and fluorapatite (FA) [Ca 10 (PO 4 ) 6 F 2 ], respectively [118,119]. When compared to HA, FHA and FA have shown improved cell proliferation and differentiation [119,120].…”

Section: Calcium Phosphatesmentioning

confidence: 99%

Freeze Casting with Bioceramics for Bone Graft Substitutes

Yin

Naleway

2022

Biomedical Materials & Devices

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Freeze casting with bioceramics affords the opportunity to create the next generation of bone graft substitutes. Because of its versatile material fabrication process and effective methods of structural control, freeze casting helps to meet the many criteria that are required of viable bone graft substitute biomaterials. In combination with biocompatible and resorbable ceramics and ceramic composites that can offer bone growth through osteoconduction, this process helps provide a tailored pore structure while maintaining the necessary mechanical properties for bone growth. Here, the advantages of freeze casting with bioceramics for orthopedic and dental applications are summarized: in particular, these advantages include its compatibility with a large variety of bioceramics, many forms of both uniform and localized structure control, and its ability to be used in combination with other advanced manufacturing processes.

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Characterization and evaluation of fluoridated apatites for the development of infection-free percutaneous devices

Cited by 16 publications

References 54 publications

A Highly Ordered, Nanostructured Fluorinated CaP‐Coated Melt Electrowritten Scaffold for Periodontal Tissue Regeneration

A Highly Ordered, Nanostructured Fluorinated CaP‐Coated Melt Electrowritten Scaffold for Periodontal Tissue Regeneration

Junctional epithelium and hemidesmosomes: Tape and rivets for solving the “percutaneous device dilemma” in dental and other permanent implants

Freeze Casting with Bioceramics for Bone Graft Substitutes

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