Characterization and Optimization of Phytosome Formulation Containing Alcohol-free Umckalin from Pelargonium sidoides

Abstract

This research study was designed to investigate physicochemical properties of types of phytosome containing alcohol-free umckalin from Pelargonium sidoides.Fourteen different phytosomal formulations were prepared by film method using P. sidoides in various types of phosphatidylcholine; Phospholipon 85 G (P 85 G) and phospholipon 100H (PL 100H). Physicochemical properties were measured by particle size and size distribution, zeta potential and polydispersity index of optimum 4phytosomal formulation. Polarized light microscopy (PLM) techniques were employed for obtaining size distribution and surface appearance and lamellarity. The determination of vesicle types of phytosomes was performed by using PLM. The most suitable alcohol-free phytosome combination was chosen as PL 100H: DCP: CHOL (10: 1: 4) containing 1 % P.S (UP 4) because of its particle size and distribution (<1000 nm) and zeta potential (<-30 mV).

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