Characterization and quantification of major constituents of Xue Fu Zhu Yu by UPLC-DAD–MS/MS

Zhang, Lei; Lin, Zhu; Wang, Yuefei; Jiang, Zhenzuo; Chai, Xin; Zhu, Yan; Gao, Xiumei; Qi, Ai-Di

doi:10.1016/j.jpba.2011.12.026

Cited by 37 publications

(20 citation statements)

References 3 publications

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“…Similarly, the MS characteristics of kaempferol‐type flavonoid‐ O ‐glycosides (peak 45) were also identified . Peak 24 showed a loss of glucosyl (162 Da) in positive ion mode, and generated an obvious fragment ion at m/z 491 in negative ion mode because of 4‐vinylphenol loss , while compound 58 exhibited a 162 Da loss of a glucosyl group and gave an aglycone ion ([M+H‐glu] + ) at m/z 269. Both of them were definitely identified as HSYA and Ononin by comparison with the authentic standard, respectively.…”

Section: Resultsmentioning

confidence: 99%

Simultaneous determination and qualitative analysis of six types of components in Naoxintong capsule by miniaturized matrix solid‐phase dispersion extraction coupled with ultra high‐performance liquid chromatography with photodiode array detection and quadrupole time‐of‐flight mass spectrometry

Wang

Jiang

Ding

et al. 2018

J of Separation Science

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A simple and effective sample preparation process based on miniaturized matrix solid-phase dispersion was developed for simultaneous determination of phenolic acids (gallic acid, chlorogenic acid, ferulic acid, 3,5-dicaffeoylqunic acid, 1,5-dicaffeoylqunic acid, rosmarinic acid, lithospermic acid, and salvianolic acid B), flavonoids (kaempferol-3-O-rutinoside, calycosin, and formononetin), lactones (ligustilide and butyllidephthalide), monoterpenoids (paeoniflorin), phenanthraquinones (cryptotanshinone), and furans (5-hydroxymethylfurfural) in Naoxintong capsule by ultra high-performance liquid chromatography. The optimized condition was that 25 mg Naoxintong powder was blended homogeneously with 100 mg Florisil PR for 4 min. One milliliter of methanol/water (75:25, v/v) acidified by 0.05% formic acid was selected to elute all components. It was found that the recoveries of the six types of components ranged from 61.36 to 96.94%. The proposed miniaturized matrix solid-phase dispersion coupled with ultra high-performance liquid chromatography was successfully applied to simultaneous determination of the six types of components in Naoxintong capsules. The results demonstrated that the proposed miniaturized matrix solid-phase dispersion coupled with ultra high-performance liquid chromatography could be used as an environmentally friendly tool for the extraction and determination of multiple bioactive components in natural products.

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Section: Resultsmentioning

confidence: 99%

Simultaneous determination and qualitative analysis of six types of components in Naoxintong capsule by miniaturized matrix solid‐phase dispersion extraction coupled with ultra high‐performance liquid chromatography with photodiode array detection and quadrupole time‐of‐flight mass spectrometry

Wang

Jiang

Ding

et al. 2018

J of Separation Science

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“…. Based on the information above and results from several references , compounds 10 , 13 , 16 , and 25 were tentatively identified.…”

Section: Resultsmentioning

confidence: 99%

“…The main chemical constituents in XFZYD include flavonoids (from C. tinctorius, Glycyrrhiza uralensis , and C. aurantium ), organic acids (from P. lactiflora and G. ralensis ), terpenoids (from G. uralensis ), and steroidal saponins (from B. chinense and G. uralensis ) . These chemical constituents have important roles in the treatment of many cardiovascular diseases, including antiplatelet aggregation and antithrombosis , antioxidation , atherosclerosis , antiatherogenic , hyperlipidemia , and hypocholesterolemic .…”

Section: Introductionmentioning

confidence: 99%

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Qualitative analysis of major constituents from Xue Fu Zhu Yu Decoction using ultra high performance liquid chromatography with hybrid ion trap time‐of‐flight mass spectrometry

Xia

Liu

et al. 2016

J of Separation Science

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Xue Fu Zhu Yu Decoction, a famous formula that has been used for treating many blood stasis-caused diseases for many centuries, comprises 11 kinds of traditional Chinese medicines. A convenient, efficient, and rapid analytical method was developed to simultaneously determine the major compounds in this decoction. An ultra-high performance liquid chromatography with hybrid ion trap time-of-flight mass spectrometry method was used to rapidly separate and detect the major constituents of the decoction. Using this technique, we identified or tentatively identified 34 compounds, including 21 flavonoids, 5 terpenoids, 3 organic acids, 2 lactones, 1 alkaloid, 1 amino acid, and 1 cyanogenic glycoside. The MS analysis of these constituents was described in detail. Findings may contribute to future metabolic and pharmacokinetic studies of this medicine.

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“…Xuefu-Zhuyu decoction (XFZY) was described in an ancient book called “Yi-Lin-Gai-Cuo” in early 18th century [174] and is composed of two classic formulae (Taohong-Siwu decoction and Sini decoction): Bupleuri Chinensis Radix, Angelicae Sinensis Radix, Rehmanniae Radix, Paeoniae Rubra Radix, Carthami Flos, Persicae Semen, Aurantii Fructus Immaturus, Glycyrrhizae Radix, Platycodi Radix, Chuanxiong Rhizoma, and Achyranthis Bidentatae Radix [175]. It is a usual TCM formula to treat blood stasis in the chest region [176].…”

Section: Studies Of Tcm Formulaementioning

confidence: 99%

A Review on the Traditional Chinese Medicinal Herbs and Formulae with Hypolipidemic Effect

Sham

Chan

Wang

et al. 2014

BioMed Research International

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Hyperlipidemia, characterized by the abnormal blood lipid profiles, is one of the dominant factors of many chronic diseases such as diabetes, obesity, and cardiovascular diseases (CVD). For the low cost, effectiveness, and fewer side effects, the popularity of using traditional Chinese medicine (TCM) to handle hyperlipidemia is increasing and its role in health care has been recognized by the public at large. Despite the importance of TCM herbs and formulations, there is no comprehensive review summarizing their scientific findings on handling hyperlipidemia. This review summarizes the recent experimental and clinical results of nine representative single Chinese herbs and seven classic TCM formulae that could improve lipid profiles so as to help understand and compare their underlying mechanisms. Most of single herbs and formulae demonstrated the improvement of hyperlipidemic conditions with multiple and diverse mechanisms of actions similar to conventional Western drugs in spite of their mild side effects. Due to increasing popularity of TCM, more extensive, well-designed preclinical and clinical trials on the potential synergistic and adverse side effects of herb-drug interactions as well as their mechanisms are warranted. Hyperlipidemic patients should be warned about the potential risks of herb-drug interactions, particularly those taking anticoagulants and antiplatelet drugs.

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Characterization and quantification of major constituents of Xue Fu Zhu Yu by UPLC-DAD–MS/MS

Cited by 37 publications

References 3 publications

Qualitative analysis of major constituents from Xue Fu Zhu Yu Decoction using ultra high performance liquid chromatography with hybrid ion trap time‐of‐flight mass spectrometry

A Review on the Traditional Chinese Medicinal Herbs and Formulae with Hypolipidemic Effect

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