Characterization and statistical optimization of γ-PGA produced by Bacillus megaterium UP47 isolated from Pentaclethra macrophylla

Odeniyi, Olubusola Ayoola; Omoleye, Temiloluwa E

doi:10.17219/pim/143975

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…Antibacterial activity was significantly higher against gram-positive bacteria compared to gram-negative bacteria. Different Bacillus megaterium UP47-purified γ-PGA concentrations have also demonstrated antimicrobial properties against gram-negative and gram-positive pathogens ( pseudomonas aeruginosa, Klebsiella pneumoniae, shigella dysenteriae, Escherichia coli, and staphylococcus aureus ) ( Lee et al, 2014 ; Ajayeoba, 2019; Odeniyi and Omoleye, 2021 ). Odeniyi and Omoleye (2021) observed that even a low γ-PGA concentration (0.5 mg/mL) could successfully inhibit overnight cultures of E. coli, S. dysenteriae, P. aeruginosa, and S. aureus.…”

Section: Applications Of γ-Pgamentioning

confidence: 99%

Poly (γ) glutamic acid: a unique microbial biopolymer with diverse commercial applicability

Elbanna,

Alsulami,

Neyaz

et al. 2024

Front. Microbiol.

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Microbial biopolymers have emerged as promising solutions for environmental pollution-related human health issues. Poly-γ-glutamic acid (γ-PGA), a natural anionic polymeric compound, is composed of highly viscous homo-polyamide of D and L-glutamic acid units. The extracellular water solubility of PGA biopolymer facilitates its complete biodegradation and makes it safe for humans. The unique properties have enabled its applications in healthcare, pharmaceuticals, water treatment, foods, and other domains. It is applied as a thickener, taste-masking agent, stabilizer, texture modifier, moisturizer, bitterness-reducing agent, probiotics cryoprotectant, and protein crystallization agent in food industries. γ-PGA is employed as a biological adhesive, drug carrier, and non-viral vector for safe gene delivery in tissue engineering, pharmaceuticals, and medicine. It is also used as a moisturizer to improve the quality of hair care and skincare cosmetic products. In agriculture, it serves as an ideal stabilizer, environment-friendly fertilizer synergist, plant-growth promoter, metal biosorbent in soil washing, and animal feed additive to reduce body fat and enhance egg-shell strength.

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Section: Applications Of γ-Pgamentioning

confidence: 99%

Poly (γ) glutamic acid: a unique microbial biopolymer with diverse commercial applicability

Elbanna,

Alsulami,

Neyaz

et al. 2024

Front. Microbiol.

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Production of gamma‐polyglutamic acid microgel by Bacillus species: Industrial applications and future perspectives

Pal,

Singh,

Sarangi

et al. 2024

Polymers for Advanced Techs

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Abstractγ‐Polyglutamic acid (γ‐PGA) microgel, produced by Bacillus spp., represents a promising biomaterial with diverse industrial applications due to its biodegradability, biocompatibility, and nontoxic nature. This review explores the current methodologies in the industrial production of γ‐PGA microgel, emphasizing the optimization of fermentation conditions, genetic engineering of Bacillus strains, and advances in downstream processing techniques. Key applications in pharmaceuticals, agriculture, and environmental management are discussed, highlighting its role in drug delivery systems, as a biocontrol agent, and in wastewater treatment. Future perspectives include enhancing production efficiency through synthetic biology, expanding its application scope, and addressing economic and regulatory challenges to facilitate broader adoption. The integration of innovative technologies and multidisciplinary approaches is crucial for the sustainable development and commercial success of γ‐PGA microgel.

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The evaluation of Bacillus-secreted polyglutamic acid as anti-scaling treatment for circulating cooling water

Yan

et al. 2022

Environ Sci Pollut Res

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Characterization and statistical optimization of γ-PGA produced by Bacillus megaterium UP47 isolated from Pentaclethra macrophylla

Abstract: Odeniyi OA, Omoleye TE. Characterization and statistical optimization of γ-PGA produced by Bacillus megaterium UP47 isolated from Pentaclethra macrophylla [published online as ahead of print on December 15, 2021].

Cited by 3 publications

References 26 publications

Poly (γ) glutamic acid: a unique microbial biopolymer with diverse commercial applicability

Poly (γ) glutamic acid: a unique microbial biopolymer with diverse commercial applicability

Production of gamma‐polyglutamic acid microgel by Bacillus species: Industrial applications and future perspectives

The evaluation of Bacillus-secreted polyglutamic acid as anti-scaling treatment for circulating cooling water

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